Factbox: The race for a coronavirus vaccine

AnGes

28/09/2020 21:29

(Adds details on Novavax, Inovio and JNJ)
    Sept 21 (Reuters) - More than 150 potential vaccines are being developed and tested globally to stop the COVID-19 pandemic,
with 38 in human trials, according to the World Health Organization (WHO). 
    The following list tracks the latest developments from major drugmakers and research institutes that have started human
trials for their vaccine candidates:
    For a separate FACTBOX on treatments under development, click  urn:newsml:reuters.com:*:nL4N2BH35E
   
 Company                      State of play                                        Development phase 
 Not applicable               Russia completes volunteer recruitment for           Vaccine produced antibody response in all
                              late-stage trials of Sputnik V vaccine, developed    participants in early-stage
                              by Moscow's Gamaleya Research Institute              trials urn:newsml:reuters.com:*:nR4N2DE022
 AstraZeneca  AZN.L           Some trials of British drugmaker's vaccine have      Late-stage trials  urn:newsml:reuters.com:*:nL1N2GB17O
                              resumed after being voluntarily paused due to an     
                              unexplained illness in a study participant           
 Sinopharm  1099.HK           Developing two vaccines, one of which has shown      UAE grants emergency approval; late-stage
                              promise in humans                                    trials in Bahrain ongoing 
 Pfizer  PFE.N  and BioNTech  Vaccine produced virus-neutralizing antibodies in    Expects late-stage data in October, plans to
 SE  22UAy.F                  early-stage trials                                   submit for approval immediately   urn:newsml:reuters.com:*:nL8N2G04AV
 Moderna Inc  MRNA.O          On track to produce 20 million doses by end of the   30,000-subject final stage trial began in
                              year                                                 July  urn:newsml:reuters.com:*:nL4N2GF34Y
 Sinovac Biotech  SVA.O       CoronaVac approved for emergency use in China to     Launched final-stage trial in Indonesia
                              vaccinate high-risk groups such as medical staff      urn:newsml:reuters.com:*:nL4N2FV050
 CanSino Biologics  6185.HK   Early results showed vaccine is safe                 Late-stage trials have begun in Russia
                                                                                    urn:newsml:reuters.com:*:nL4N2FJ2OX
 Inovio Pharma  INO.O         U.S. health regulator puts a hold on plans to start  Mid-to-late-stage trials were planned for
                              final trials; FDA seeks more info, including         this month but is currently on hold; Company
                              details on a delivery device used to inject genetic  aims to respond to FDA's queries in
                              material into cells                                  October urn:newsml:reuters.com:*:nL4N2GP2HE
 Chongqing Zhifei Biological  Unit Anhui Zhifei Longcom Biopharmaceutical has      Mid-stage trial  urn:newsml:reuters.com:*:nL4N2E018D
 Products  300122.SZ          begun human trials                                   
 Bharat Biotech               Vaccine approved for human trials in India           Early- to mid-stage trials  urn:newsml:reuters.com:*:nL4N2E70F6
 Johnson & Johnson  JNJ.N     Has started a late-stage decisive study of a         A 60,000 person late-stage study has begun
                              single-shot COVID-19 vaccine                          urn:newsml:reuters.com:*:nL2N2GK0J6
 Novavax  NVAX.O              Has started late-stage study (10,000 volunteers) in  Late-stage study in UK has begun  
                              UK; Aims to start another late-stage trial with       urn:newsml:reuters.com:*:nL4N2FQ32J
                              30,000 people in U.S. in October                     
 GlaxoSmithKline  GSK.L       Partnered with Sanofi  SASY.PA  to develop a         Early-mid stage trials to begin in September
                              vaccine                                               urn:newsml:reuters.com:*:nP6N2DU00V
 CureVac                      German biotech expects data in September/October     Mid-stage trial  urn:newsml:reuters.com:*:nL4N2FG3OM
 Clover Biopharmaceuticals    Chinese developer received $66 mln from an epidemic  Early-stage trials  urn:newsml:reuters.com:*:nL4N2DW1WI
                              response group                                       
 Not applicable               Scientists at Imperial College London running        Early-stage trials  urn:newsml:reuters.com:*:nL8N2DS5JI
                              trials                                               
 Genexine  095700.KQ          South Korean company has begun human trials          Early-stage trials  urn:newsml:reuters.com:*:nL4N2DW1T3
 Not applicable               Institute of Medical Biology at Chinese Academy of   Mid-stage trials  urn:newsml:reuters.com:*:nL4N2DY03I
                              Medical Sciences testing a vaccine                   
 Walvax Biotechnology         Trials sponsored by Walvax and a Chinese military    Mexico to conduct late-stage trials
  300142.SZ                   research institute, have begun                        urn:newsml:reuters.com:*:nL1N2FD0OJ
 Medicago                     Studying a plant-based vaccine                       Early-stage trials  urn:newsml:reuters.com:*:nL3N2EK3DD
 Cadila Healthcare            Plans to finish late-stage trials by early 2021      Early-stage trials  urn:newsml:reuters.com:*:nL5N2EO1QP
  CADI.NS                                                                          
 Not applicable               University of Queensland began human trials with     Early-stage testing (https://bit.ly/2Eo5iDg)
                              Australia's CSL  CSL.AX .                            
 Arcturus Therapeutics        Dosed first group of participants in early-stage     Early-stage testing  urn:newsml:reuters.com:*:nL4N2FD31J
  ARCT.O  and Duke-NUS        trials                                               
 Osaka University, AnGes,     A single-center trial in 30 healthy volunteers       Early-stage testing (https://bit.ly/3gaEiFB)
 Takara Bio  4974.T                                                                
 Kentucky Bioprocessing       British American Tobacco  BATS.L  unit expects to    Early-stage testing planned (https://bit.ly/2BJDU1M)
                              begin trial in 180 adults                            
 Vaxine Pty/Medytox           Expects to start mid-stage trials                    Early-stage testing  urn:newsml:reuters.com:*:nL3N2F034D
 Medigen Vaccine Biologics    Begins early-stage study in 45 people                Early-stage trial (https://bit.ly/2XbnAOS)
 Corp/NIAID/Dynavax                                                                
 Merck & Co  MRK.N            Expects to begin human trials later this year        Early-stage trial planned  urn:newsml:reuters.com:*:nL3N2F241V
 ReiThera/Leukocare/Univerce  Collaborating on a potential shot                    Early-stage trial (https://bit.ly/2YgDJmo)
 lls                                                                               
 Not applicable               Cuba's Instituto Finlay de Vacunas begins            Early-stage trial (https://bit.ly/3gsMu35)
                              early-stage trials in 676 participants               
 Merck's unit Themis          Merck's unit started early-stage study in            Early-stage trial that aims to recruit 260
 BIO/Institute                collaboration with Institute Pasteur                 healthy volunteers  urn:newsml:reuters.com:*:nL4N2G83QW
 Pasteur/University of                                                             
 Pittsburg CVR                                                                     
 Not applicable               Rospotrebnadzor, a Russian federal agency, begins    Early-stage trials (https://bit.ly/2YzhwjH)
                              studying potential vaccine                           
 Research Institute for       Studying QazCovid-in in healthy volunteers aged      Early-mid stage trials (https://bit.ly/3jOYIFc)
 Biological Safety            18-50                                                
 Problems, Rep of Kazakhstan                                                       
 West China Hospital,         Studying safety, tolerability and immunogenicity of  Early-stage trials (https://bit.ly/3jK7CUE)
 Sichuan University           vaccine candidate in healthy Chinese adults          
 Beijing Wantai Biological    Candidate approved by China's National Medical       Early-stage trials (https://bit.ly/3cmG9FZ)
 Pharmacy/Xiamen University   Products Administration for clinical trials          
                                                                                   
 COVAXX                       Brazilian hospital group DASA to conduct             Early-stage trials in Taiwan  urn:newsml:reuters.com:*:nL1N2G61RF
                              mid/late-stage trials                                
 University Hospital          To begin early stage trials by end of September in   Early-stage studies (https://bit.ly/3iQTE3i)
 Tuebingen                    36 adults aged 18-75 years                           
 Institute of Biotechnology,  Began early-stage studies of vaccine candidate in    Early-stage studies (https://bit.ly/2FQy2Wv)
 Academy of                   168 participants                                     
 Military Medical Sciences,                                                        
 PLA of China                                                                      
 
 (Reporting by Vishwadha Chander and Manas Mishra in Bengaluru; Editing by Shounak Dasgupta, Sriraj Kalluvila and Maju Samuel)
 ((Manas.Mishra@thomsonreuters.com; www.twitter.com/Manasmishra24; within U.S. +1 646 223 8780, outside U.S. +91 806749 2709))