Coiled Therapeutics - Director/PDMR Shareholding

Coiled Therapeutics

28/09/2026 10:33

RNS Number : 5814W
  
Coiled Therapeutics PLC
  
28 September 2026
  
 


28 September 2026
Coiled Therapeutics plc
("Coiled Therapeutics" or the "Company")
 
Director/PDMR Shareholding
 
Coiled Therapeutics (AIM: COIL / OTCQB: COTXF), the clinical-stage precision oncology company developing differentiated small molecule therapies for genetically defined cancers, advises that Stephen West, Non-Executive Director, has today purchased ordinary shares of £0.01 each in the Company ("Ordinary Shares"), as detailed below:
 




Number of Ordinary Shares Acquired


Average Price Paid per Ordinary Share


Total Consideration Paid (including charges)


Number of Ordinary Shares Now Held


% of Company's Issued Capital




531,743


7.52 pence


£40,016.77


2,700,368


0.63%




 
Regulatory Information
This Announcement contains inside information for the purposes of the UK version of the market abuse regulation (EU No. 596/2014) as it forms part of United Kingdom domestic law by virtue of the European Union (Withdrawal) Act 2018 ("UK MAR").
-ENDS-
Enquiries:




Coiled Therapeutics plc
Sotirios Stergiopoulos (Chairman)
Sridhar Vempati (CEO)
 


Via Burson Buchanan




SP Angel Corporate Finance LLP (Nominated Adviser & Joint Broker)
David Hignell / Adam Cowl / Devik Mehta (Corporate Finance)
Vadim Alexandre / Rob Rees (Corporate Broking)
 


+44 (0)20 3470 0470




Shore Capital Stockbrokers Limited (Joint Broker)
David Coaten / Sophie Collins
 


+44 (0)20 7408 4090




CPS Capital Group Pty Ltd (Joint Broker)
Jason Peterson / David Valentino


+61 (0)8 9223 2222




 








Burson Buchanan (Public Relations)


+44 (0)20 7466 5000




Henry Harrison Topham / Jamie Hooper / Toto Berger


















Harbor Access (US Investor Relations)


+1 475 477 9404




Matt Kelly / Jonathan Paterson








 
About Coiled Therapeutics plc
Coiled Therapeutics (AIM: COIL) (OTCQB: COTXF) is an AIM-listed, clinical-stage precision oncology company advancing first-in-class small molecule therapies targeting validated cancer dependencies. Its lead programme, AO-252, is a novel TACC3 inhibitor currently being evaluated in an ongoing Phase I clinical trial in the U.S. (ClinicalTrials.gov ID: NCT06136884). The Company's clinical development strategy focuses on generating evidence in selected tumour types, including ovarian and prostate cancer, to support potential pharmaceutical partnerships. Its broader pipeline includes a STAT-6 siRNA programme for immunology indications.
 
About AO-252
AO-252 is a first-in-class, orally administered, brain-penetrant small molecule designed to selectively inhibit Transforming Acidic Coiled-Coil containing protein 3 (TACC3). TACC3 has emerged as a validated cancer dependency across multiple aggressive solid tumours and is largely dispensable in normal adult cells, supporting the potential for a broad therapeutic window.
 
By disrupting TACC3-driven protein interactions, AO-252 induces mitotic and replication stress, impairs DNA damage repair and promotes cancer cell death. Its ability to cross the blood-brain barrier is a key differentiator, supporting its potential to treat both primary brain tumours and brain metastases.
 
The Company is currently enrolling patients in dose-escalation cohorts evaluating the new lipid-based softgel formulation of AO-252. Phase I/II dose-expansion cohorts in ovarian and prostate cancer are planned to follow once the optimal dose has been established.
 
For more information, please visit: www.coiledplc.com and follow us on LinkedIn.




The notification below, made in accordance with the requirements of the UK MAR, provides further detail:
 
NOTIFICATION AND PUBLIC DISCLOSURE OF TRANSACTIONS BY PERSONS DISCHARGING MANAGERIAL RESPONSIBILITIES AND PERSONS CLOSELY ASSOCIATED WITH THEM
 




1


Details of the person discharging managerial responsibilities / person closely associated




a)


Name


Stephen West




2


Reason for the notification




a)


Position/status


Non-Executive Director




b)


Initial notification /Amendment


Initial




3


Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor




a)


Name


Coiled Therapeutics plc




b)


LEI


254900P4SISIWOR9RH34




4


Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted




a)


Description of the financial instrument, type of instrument
Identification code


Ordinary shares of £0.01 par value
 
ISIN: GB00BSHRN331




b)


Nature of the transaction


Purchase of 531,743 Ordinary Shares




c)


Price(s) and volume(s)


Price(s)


Volume(s)








7.399 pence per share


270,306












7.650 pence per share


261,437




d


Aggregated information
- Aggregated volume
- Price


 
-       531,743
-       7.52p




e)


Date of the transactions


28 September 2026




f)


Place of the transactions


London Stock Exchange (XLON); AIM




 




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