** Biopharma co ARCT.O announced data from early-to-mid
stage study of its COVID-19 mRNA vaccine ARCT-021, which showed
the vaccine was well tolerated in 100% subjects and led to a
potent immune response to the virus
** Co also received approval from Singapore Health Sciences
Authority to proceed with a mid-stage trial of its COVID-19
vaccine candidate urn:newsml:reuters.com:*:nBw92Sh8Ya
** 3 brokerages downgrade stock; shares plunge ~52% to
$44.36
UNDERWHELMING EARLY-STAGE DATA
** Baird ("neutral"; PT:$69) calls the study data
"underwhelming" and is skeptical of the path for this mRNA
vaccine in COVID-19
** H.C. Wainwright ("neutral"; PT:$50) says it has lost
confidence in the vaccine's potential to provide meaningful
protection from the SARS-CoV-2 infection
** Guggenheim ("buy") says only a successful late-stage
efficacy trial will resolve the growing controversy around
ARCT-021
** Laidlaw ("buy"; PT $152), however, calls the news
"encouraging" saying a separate mid-stage study might be
required
(Reporting by Trisha Roy in Bengaluru)
((Trisha.Roy@thomsonreuters.com; within U.S. +1 646 223 8780,
outside U.S. +91 80 6182 3635;))