** U.S.-listed shares in Danish biotech company Orphazyme
ORPH.O up 3% to $3.26 premarket
** ORPH-related message volume nearly triples on
trading-focused social media site Stocktwits; fourth-most
discussed stock on site
** About 96% of Stocktwits posts related to ORPH reflect
positive sentiment
** ORPH shares have surged about 44% over the past two days
with trading volumes topping 40 mln on Tuesday, compared with
its 25-DMA of 7.3 mln
** Shares of the company tumbled about 50% in June after
U.S. health regulators rejected its key drug candidate to treat
genetic disorder Niemann-Pick disease type C urn:newsml:reuters.com:*:nL2N2O00CG
** Up to Wednesday's close, stock down 43.5% YTD
(Reporting by Dania Nadeem)