** Shares of Syngene International SYNN.NS fall as much as 8.1% to 506 rupees, lowest level since March 2021
** On Friday, co slashed FY26 revenue estimate from above 5% to 3-5%
**Jefferies downgrades stock to "underperform"; PT to 480 rupees from 660 rupees
** Says contract research firm missed revenue, EBITDA estimates; co's guidance was lowered due to destocking challenges; likely to impact FY27 too
** Adds, SYNN lacks a meaningful project pipeline, leading to growth stagnation
** More than 3 mln shares traded so far vs 30 day avg of 717,248 shares
** Stock fell 24.2% in 2025
(Reporting by Mridula Kumar in Bengaluru)
((Mridula.Kumar@thomsonreuters.com;))