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WWH Worldwide Healthcare Trust News Story

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REG-Worldwide Healthcare: Audited Results for the year ended 31 March 2022

LONDON STOCK EXCHANGE ANNOUNCEMENT

Worldwide Healthcare Trust PLC (the “Company”)

Audited Results for the Year Ended 31 March 2022

The Company’s annual report will be posted to shareholders on 6 June 2022.
Members of the public may obtain copies from Frostrow Capital LLP, 25
Southampton Buildings, London WC2A 1AL or from the Company’s website at
www.worldwidewh.com where up to date information on the Company, including
daily NAV, share prices and fact sheets, can also be found.

The Company's annual report for the year ended 31 March 2022 has been
submitted to the UK Listing Authority, and will shortly be available for
inspection on the National Storage Mechanism (NSM):

https://data.fca.org.uk/#/nsm/nationalstoragemechanism

(Documents will usually be available for inspection within two business days
of this notice being given)

Mark Pope, Frostrow Capital LLP, Company Secretary – 0203 008 4913

COMPANY PERFORMANCE

HISTORIC PERFORMANCE FOR THE YEARS ENDED 31 MARCH

                                                                                               2017      2018      2019      2020      2021      2022   
 Net asset value per share (total return)* (†)                                                28.9%      2.8%     13.7%      6.5%     30.0%    (5.8%)   
 Benchmark (total return)* (†)                                                                24.5%    (2.5%)     21.1%      5.7%     16.0%     20.4%   
 Net asset value per share                                                                 2,367.2p  2,411.1p  2,722.9p  2,868.9p  3,703.0p  3,465.2p   
 Share price                                                                               2,304.0p  2,405.0p  2,730.0p  2,920.0p  3,695.0p  3,275.0p   
 (Discount)/Premium of share price to net asset value per share (†)                          (2.7%)    (0.3%)      0.3%      1.8%    (0.2%)    (5.5%)   
                                                                                                    
 Dividends per share                                                                          22.5p     17.5p     26.5p     25.0p     22.0p    26.5p]   
 Leverage (†)                                                                                 16.9%     16.4%      4.9%     12.0%      7.6%     10.9%   
 Ongoing charges (†)                                                                           0.9%      0.9%      0.9%      0.9%      0.9%      0.9%   
 Ongoing charges (including performance fees paid or crystallised during the year) (†)         1.0%      1.2%      1.1%      0.9%      0.9%      1.4%   

*          Source: Morningstar

†         Alternative Performance Measure (see Glossary).

CHAIRMAN’S STATEMENT

SIR MARTIN SMITH

INVESTMENT PERFORMANCE

Following last year’s strong returns, both on an absolute and on a relative
basis, the year under review has proved to be a challenging one for the
Company. The Company’s net asset value per share total return was -5.8%
(2021:+30.0%) and the share price total return was -10.8% (2021: +27.4%), both
significantly underperforming the Company’s Benchmark, the MSCI World Health
Care Index measured on a net total return, sterling adjusted basis, which rose
by 20.4% during the year (2021: rose by 16.0%). The disparity between the
performance of the Company’s net asset value per share and its share price
is reflected in the widening of the Company’s share price discount to its
net asset value per share from 0.2% at the start of the Company’s financial
year to 5.5% at 31 March 2022.

The majority of the Company’s assets are denominated in U.S. dollars, and it
should be noted that the Company’s net asset value performance was helped by
the weakness of sterling over the year, particularly against the dollar, where
it depreciated by 4.6%.

The negative absolute return over the year to 31 March 2022 reflected a mildly
positive first half, where the net asset value per share total return was
+0.4% (2021:+23.1%) compared to a rise in the Benchmark of 13.0% (2021: a rise
of 15.3%) and a weaker second half where the net asset value total return was
-6.2% (2021-5.6%) compared to a rise in the Benchmark of 7.4% (2021: 0.7%).

During the year the Company’s Portfolio Manager continued to pursue a
strategy of being underweight in large pharmaceutical companies and overweight
in both emerging markets and emerging biotechnology companies; an approach
which had served the Company well during the previous year but was the
principal reason for the Company’s relative underperformance during the year
under review.

While the healthcare sector as a whole performed well during the year, macro
considerations rather than company fundamentals were deemed to be most
important by investors. In addition, the “growth-to-value” rotation which
has tended to favour well-established companies despite their less-exciting
growth prospects also showed that investors have been less willing to take on
investment risk more generally. This risk aversion has hurt those sectors
where we have been strategically overweight, including emerging biotechnology,
China healthcare, and innovative tools.

Risk aversion has also resulted in further pressure on performance as the
value of the smaller capitalisation stocks we own has lagged while large
capitalisation pharmaceutical stocks have outperformed the rest of the
healthcare sector, particularly during the last quarter of the financial year.
It should be emphasised, however, that this extraordinary fall in the
valuation of the biotechnology and other sectors reflects a change in investor
sentiment rather than any significant deterioration in the performance of the
underlying companies. It is for this reason that we remain confident that
these stocks will recover in due course.

Our Portfolio Manager continues to adopt both a pragmatic and tactical
approach with regard to the use of leverage. Leverage levels varied over the
course of the year, with the net effect of a detraction of 1.0% from
performance.

The long-term performance of the Company, however, continues to be strong, and
it should be noted that from the Company’s inception in 1995 to 31 March
2022, the total return of the Company’s net asset value per share has been
+3,866.7%, equivalent to a compound annual return of +14.7%. This compares to
a cumulative blended Benchmark return of +2,133.6%, equivalent to a compound
annual return of +12.2% over the same period.

Further information on the healthcare sector, the Company’s investments and
performance during the year can be found in the Portfolio Manager’s Review.

CAPITAL

The Company’s share price traded close to the net asset value per share for
much of the year under review. In accordance with the Company’s share price
premium management policy 1,227,500 new shares were issued during the year at
an average premium of 0.8% to the Company’s cum income net asset value per
share. This issuance gave rise to the receipt of £45.5m of new funds to the
Company, which have been invested in line with the investment policy. The
Company’s ongoing share issuance programme triggered the requirement for the
Company to publish a prospectus in July 2021 which provided authority for the
issuance of 20 million new shares.

However, toward the end of the calendar year, the Company’s share price fell
to a discount to the net asset value per share and 80,509 shares were
repurchased during the Company’s financial year for treasury, in accordance
with the Company’s share price discount management policy, at a discount of
8.4% to the Company’s cum income net asset value per share, at cost of
£2.5m.

At the year-end there were 65,457,246 shares in issue (excluding the 80,509
shares held in treasury (2021: 64,310,255 with no shares held in treasury)).
Since the year-end, to 25 May 2022, the latest practicable date prior to the
publication of this report, a further 223,842 shares were repurchased for
treasury at a discount of 7.0% to the Company’s cum income net asset value
per share, at cost of £7.3m. At the time of writing the share price discount
stands at 4.6%.

REVENUE AND DIVIDEND

Shareholders will be aware that it remains the Company’s policy to pursue
capital growth for shareholders and to pay dividends at least to the extent
required to maintain investment trust status. Therefore, the level of
dividends declared can go down as well as up. An increased interim dividend of
7.0p per share for the year ended 31 March 2022, was paid on 11 January 2022
to shareholders on the register on 19 November 2021 (2021: 6.5p per share).
Due in large part to an increase in exposure to higher yielding stocks in the
portfolio and also to the weakness of sterling, the Company’s revenue return
per share for the year as a whole increased to 26.8 pence (2021: 24.1 pence).
Accordingly, the Board is proposing an increased final dividend of 19.5 p per
share (2021:15.5p per share) which, together with the interim dividend already
paid, makes a total dividend for the year of 26.5p (2021: 22.0p per share).
Based on the closing mid-market share price of 3040.0p on 25 May 2022, the
total dividend payment for the year represents a current yield of 0.9%.

The final dividend will be payable, subject to shareholder approval, on 15
July 2022 to shareholders on the register of members on 10 June 2022. The
associated ex-dividend date will be 9 June 2022.

The Company’s dividend policy will be proposed for approval at the
forthcoming Annual General Meeting.

THE BOARD

The process of Board refreshment continues and, as indicated in my last
year-end statement, following David Holbrook’s retirement last year, I shall
be stepping down from the Board on 6 July 2022, the date of this year’s
Annual General Meeting. It has been agreed that in the interests of
maintaining an orderly succession process, Doug McCutcheon will extend his
term and assume the Chairmanship following my retirement. I wish him every
success for the future. Bina Rawal will take over as Chair of the Management
Engagement & Remuneration Committee at the same time.

I have served on the Board for 14 years, 13 of which as Chairman, and have
been fortunate to be supported by a group of very loyal, professional and hard
working colleagues during that time. I would also like to pay tribute to the
unswerving dedication of both our Portfolio Manager, OrbiMed and our AIFM,
Company Secretary and Administrator, Frostrow Capital. Although recent results
have been disappointing, I believe that it will be only a matter of time
before the skills and experience of our Portfolio Manager will enable the
Company to resume its excellent long-term record.

The process of recruiting a new Director is ongoing. Shareholders will be kept
informed of developments as they occur. As new members are recruited, the
Board will remain mindful of its commitment to a policy of diversity.

ENVIRONMENTAL, SOCIAL AND GOVERNANCE (ESG) MATTERS

ESG matters are an important priority for the Board and Bina Rawal and I have
been working closely with our Portfolio  Manager to identify an appropriate
set of policies to address them.

Our Portfolio Manager continues to develop tools for assessing the
sustainability of the Company’s portfolio including measuring the net
impacts that individual portfolio companies have on both the environment and
society, as much as is possible with the availability and consistency of the
reporting of non--financial data pertaining to both ESG matters and also to
climate change. OrbiMed is committed to taking a leading role in the
development of meaningful ESG engagement practices in the healthcare sector.
As part of this they facilitate dialogue and an exchange of leading practices
among investors, companies and other relevant experts on ESG in the large
capitalisation pharmaceutical sector. They also engage with a broad range of
companies on a regular basis where areas of improvement can be identified.
Further information on both ESG matters and climate change can be found in the
Portfolio Manager’s ESG report.

PERFORMANCE FEE

I mentioned last year that as a result of the continued cumulative
outperformance in the year, there was a provision in our year-end accounts of
£31.7 million for future performance fee payments. However, only if
outperformance was maintained to the relevant quarterly calculation dates
would this provision become payable. During the year under review, a
performance fee of £12.9 million crystallised and became payable on 30 June
2021. However, due to underperformance against the Benchmark during the year,
the remainder of the performance fee accrual as at 31 March 2021 was reversed.
No performance fees were accrued or payable at the Company’s year-end as at
31 March 2022.

OUTLOOK

Global markets are currently experiencing unusually high levels of
uncertainty. In addition to the appalling human cost, Russia’s invasion of
Ukraine has created near-term risks for markets as high energy prices, rising
food prices and disrupted supply chains threaten a substantial increase in
global inflation. It has also cast a shadow over the longer-term outlook with
the prospect of continued raised levels of geopolitical risk and an increase
in investor risk aversion, both of which may affect markets and economic
confidence for some time.

This comes in addition to existing market and economic concerns that troubled
investors before the invasion, including the onset of U.S. Federal Reserve
tightening, the impact of COVID-19 lockdowns on supply chains and inflation
and also the outlook for China where there are problems in the real estate
sector, as well as around its zero-tolerance COVID-19 policy and heavy-handed
regulation of technology firms.

Against this challenging background, however, our Portfolio Manager OrbiMed
remains positive on the outlook for healthcare with certain of the perceived
risks associated with the sector such as an inefficient drug approval process
in the U.S. and also the spectre of drug price reform having receded.
Fundamentals, however, remain strong, particularly given the amount of
innovation that is fuelling the industry’s growth. They further believe that
the sector’s defensive growth characteristics should continue to prove
attractive in times of global uncertainty.

Your Board continues to believe that long-term investors in this sector will
be rewarded.

ANNUAL GENERAL MEETING

After COVID restrictions prevented holding meetings in person, the Board is
pleased to welcome all shareholders back to the Company’s Annual General
Meeting which offers an opportunity to meet the Directors and also to hear the
views of our Portfolio Manager. The meeting will be held at etc. venues 1-3
Bonhill Street, London EC2A 4BX on Wednesday, 6 July 2022 at 12.30pm. Of
course, should circumstances change and restrictions be reintroduced, we will
keep shareholders informed of the final arrangements for the meeting via the
Company’s website at www.worldwidewh.com.

For those investors who are not able to attend the meeting in person, a video
recording of the Portfolio Manager’s presentation will be uploaded to the
website after the meeting. Shareholders can submit questions in advance by
sending them to wwh@frostrow.com.

I encourage all shareholders to exercise their right to vote at the Annual
General Meeting and to register your votes online in advance of the meeting.
Registering your vote in advance will not restrict you from attending and
voting at the meeting in person should you wish to do so, subject of course to
any government guidance to the contrary. The votes on the resolutions to be
proposed at the Annual General Meeting will be conducted on a poll. The
results of the proxy votes will be published immediately following the
conclusion of the AGM by way of a stock exchange announcement and will also be
able to be viewed on the Company’s website at www.worldwidewh.com.

Sir Martin Smith

Chairman

26 May 2022

INVESTMENT OBJECTIVE AND POLICY

INVESTMENT OBJECTIVE

The Company invests in the global healthcare sector with the objective of
achieving a high level of capital growth.

In order to achieve its investment objective, the Company invests worldwide in
a diversified portfolio of shares in pharmaceutical and biotechnology
companies and related securities in the healthcare sector. It uses gearing,
and derivative transactions to enhance returns and mitigate risk. Performance
is measured against the MSCI World Health Care Index on a net total return,
sterling adjusted basis (“Benchmark”).

INVESTMENT STRATEGY

The implementation of the Company’s Investment Objective has been delegated
to OrbiMed by Frostrow (as AIFM) under the Board’s and Frostrow’s
supervision and guidance.

Details of OrbiMed’s investment strategy and approach are set out in the
Portfolio Manager’s Review.

While the Board’s strategy is to allow flexibility in managing the
investments, in order to manage investment risk it has imposed various
investment, gearing and derivative guidelines and limits, within which
Frostrow and OrbiMed are required to manage the investments, as set out below.

Any material changes to the Investment Objective, Policy and Benchmark or the
investment, gearing and derivative guidelines and limits require approval from
shareholders.

INVESTMENT POLICY

INVESTMENT LIMITS AND GUIDELINES
* The Company will not invest more than 15% of the portfolio in any one
individual stock at the time of acquisition;
* At least 50% of the portfolio will normally be invested in larger companies
(i.e. with a market capitalisation of at least U.S.$10bn);
* At least 20% of the portfolio will normally be invested in smaller companies
(i.e. with a market capitalisation of less than U.S.$10bn);
* Investment in unquoted securities will not exceed 10% of the portfolio at
the time of acquisition;
* A maximum of 5% of the portfolio, at the time of acquisition, may be
invested in each of debt instruments, convertibles and royalty bonds issued by
pharmaceutical and biotechnology companies;
* A maximum of 30% of the portfolio, at the time of acquisition, may be
invested in companies in each of the following sectors:
* healthcare equipment and supplies
* healthcare providers and services;
* The Company will not invest more than 10% of its gross assets in other
closed ended investment companies (including investment trusts) listed on the
London Stock Exchange, except where the investment companies themselves have
stated investment policies to invest no more than 15% of their gross assets in
other closed ended investment companies (including investment trusts) listed
on the London Stock Exchange, where such investments shall be limited to 15%
of the Company’s gross assets at the time of acquisition.
DERIVATIVE STRATEGY AND LIMITS

In line with the Investment Objective, derivatives are employed, when
appropriate, in an effort to enhance returns and to improve the risk-return
profile of the Company’s portfolio. Only Equity Swaps were employed within
the portfolio during the year.

The Board has set the following limits within which derivative exposures are
managed:
* Derivative transactions (excluding equity swaps) can be used to mitigate
risk and/or enhance capital returns and will be restricted to a net exposure
of 5% of the portfolio; and
* Equity Swaps may be used in order to meet the Company’s investment
objective of achieving a high level of capital growth, and counterparty
exposure through these is restricted to 12% of the gross assets of the Company
at the time of acquisition.
The Company does not currently hedge against foreign currency exposure.

GEARING LIMIT

The Board has set a maximum gearing level, through borrowing, of 20% of the
net assets.

LEVERAGE LIMITS

Under the AIFMD the Company is required to set maximum leverage limits.
Leverage under the AIFMD is defined as any method by which the total exposure
of an AIF is increased.

The Company has two current sources of leverage: the overdraft facility, which
is subject to the gearing limit; and, derivatives, which are subject to the
separate derivative limits. The Board and Frostrow have set a maximum leverage
limit of 140% on both the commitment and gross basis.

Further details on the gearing and leverage calculations, and how total
exposure through derivatives is calculated, are included in the Glossary.
Further details on how derivatives are employed can be found in note 16.

PORTFOLIO

INVESTMENTS HELD AS AT 31 MARCH 2022

                                                                    Market value         % of 
 Investments                                          Country              £’000  investments 
 AstraZeneca                                          UK                 135,292          5.7 
 Pfizer                                               USA                117,923          4.9 
 Roche Holding                                        Switzerland        113,899          4.8 
 Bristol-Myers Squibb                                 USA                112,460          4.7 
 Horizon Therapeutics                                 USA                105,462          4.4 
 AbbVie                                               USA                101,256          4.3 
 Boston Scientific                                    USA                100,010          4.2 
 Intuitive Surgical                                   USA                 91,924          3.9 
 Humana                                               USA                 88,067          3.7 
 UnitedHealth Group                                   USA                 86,845          3.7 
 Top 10 investments                                                    1,053,138         44.3 
 Stryker                                              USA                 77,630          3.3 
 Edwards Lifesciences                                 USA                 71,813          3.0 
 BioMarin Pharmaceutical                              USA                 61,893          2.6 
 Mirati Therapeutics                                  USA                 58,981          2.5 
 Vertex Pharmaceuticals                               USA                 58,174          2.5 
 Shanghai Bio-Heart Biological Technology             China               46,558          2.0 
 DexCom                                               USA                 42,742          1.8 
 Neurocrine Biosciences                               USA                 39,067          1.6 
 Thermo Fisher Scientific                             USA                 38,886          1.6 
 Guardant Health                                      USA                 37,457          1.6 
 Top 20 investments                                                    1,586,339         66.8 
 Caris Life Science (unquoted)                        USA                 36,986          1.6 
 Daiichi Sankyo                                       Japan               36,600          1.5 
 Seagen                                               USA                 34,969          1.5 
 Tenet Healthcare                                     USA                 34,847          1.5 
 Natera                                               USA                 31,523          1.3 
 SI-BONE                                              USA                 31,479          1.3 
 Global Blood Therapeutics                            USA                 29,984          1.3 
 Argenx                                               Netherlands         27,097          1.1 
 Evolent Health                                       USA                 25,873          1.1 
 Shionogi                                             Japan               25,202          1.1 
 Top 30 investments                                                    1,900,899         80.1 
 API Holdings (unquoted)                              India               22,251          0.9 
 Joinn Laboratories China                             China               21,669          0.9 
 NanoString Technologies                              USA                 21,594          0.9 
 Chugai Pharmaceutical                                Japan               21,422          0.9 
 Arrail Group                                         China               18,581          0.8 
 Crossover Health (unquoted)                          USA                 17,499          0.7 
 EDDA (unquoted)                                      USA                 16,128          0.7 
 Visen Pharmaceutical (unquoted)                      China               15,731          0.7 
 MeiraGTx                                             USA                 15,603          0.7 
 Iovance Biotherapeutics                              USA                 14,869          0.6 
 Top 40 investments                                                    2,086,246         87.9 
 Shanghai Fosun Pharmaceutical                        China               14,838          0.6 
 Beijing Yuanxin Technology (unquoted)                China               14,705          0.6 
 Arcutis Biotherapeutics                              USA                 13,224          0.5 
 Ruipeng Pet Group (unquoted)                         China               13,101          0.5 
 Dingdang Health Technology (unquoted)                China               12,491          0.5 
 RiMAG (unquoted)                                     China               12,208          0.5 
 Theravance Biopharma                                 USA                 11,394          0.5 
 Shanghai Kindly Medical Instruments                  China               11,301          0.5 
 uniQure                                              Netherlands         11,289          0.5 
 CSPC Pharmaceutical                                  China               11,001          0.5 
 Top 50 investments                                                    2,211,798         93.1 
 Erasca                                               USA                 10,868          0.5 
 Alphamab Oncology                                    China               10,794          0.5 
 RxSight                                              USA                  9,950          0.4 
 Danaher                                              USA                  9,600          0.4 
 Celldex Therapeutics                                 USA                  9,206          0.4 
 Apollo Hospitals Enterprise                          India                8,552          0.4 
 Shanghai Junshi Biosciences                          Hong Kong            8,133          0.4 
 New Horizon Health                                   China                7,815          0.3 
 Ikena Oncology                                       USA                  7,522          0.3 
 Turning Point Therapeutics                           USA                  7,373          0.3 
 Top 60 investments                                                    2,301,611         97.0 
 Galapagos                                            Belgium              7,217          0.3 
 Clover Biopharmaceuticals                            China                6,420          0.3 
 Shenzhen Hepalink Pharmaceutical                     China                6,400          0.3 
 Simcere Pharmaceutical                               China                6,092          0.3 
 MabPlex International (unquoted)                     China                5,874          0.2 
 China Medical System                                 China                5,662          0.2 
 Harpoon Therapeutics                                 USA                  5,524          0.2 
 United Laboratories International Holdings           Hong Kong            5,336          0.2 
 Burning Rock Biotech                                 China                5,290          0.2 
 Yidu Tech                                            China                5,081          0.2 
 Top 70 investments                                                    2,360,507         99.4 
 NanoString Technologies 2.63% 01/03/2025 (unquoted)  USA                  5,024          0.2 
 Vor BioPharma                                        USA                  3,779          0.2 
 Abbisko                                              China                3,735          0.2 
 Achilles Therapeutics                                USA                  3,108          0.1 
 Passage Bio                                          USA                  2,376          0.1 
 MicroTech Medical Hangzhou                           China                  844          0.0 
 Peloton Interactive (DCC*-unquoted)                  USA                    475          0.0 
 Total equities and fixed interest investments                         2,379,848        100.2 
 OTC Equity Swaps – Financed^                                                                 
 Healthcare M&A Target Swap                           USA                 99,898          4.2 
 Apollo Hospitals                                     India               35,120          1.5 
 Less: Gross exposure on financed swaps                                (140,147)        (5.9) 
 Total OTC Swaps                                                         (5,129)        (0.2) 
 Total investments including OTC Swaps                                 2,374,719        100.0 

*          DCC = deferred contingent consideration.

^         See Glossary and note 16 for further details in relation to
the OTC Swaps.

SUMMARY

                              Market value         % of 
 Investments                         £’000  investments 
 Quoted equities                 2,207,375         93.0 
 Unquoted equities                 167,449          7.0 
 Unquoted debt securities            5,024          0.2 
 Equity swaps                      (5,129)        (0.2) 
 Total of all investments        2,374,719        100.0 

PORTFOLIO MANAGER’S REVIEW

MARKETS

2021 was another unprecedented year for the global equity markets. After the
COVID-induced volatility that characterised 2020, markets climbed higher in
2021 despite various headwinds including inflationary fears and supply chain
disruptions. The market reached new highs by the calendar year-end, only to
sell-off in the face of rising interest rates and Russia’s invasion of
Ukraine in early 2022. Of course, COVID-19 continued to cast a shadow over the
year under review, with Delta and Omicron variants inducing new waves of
infections across the globe.

Nevertheless, global equity markets produced solid double-digits returns in
the financial year. The MSCI World Index total return was +16.2% (in sterling
terms). The total return for the S&P 500 was +15.6% (in U.S. dollar terms),
notching 70 all-time highs throughout 2021 (source: Forbes). Meanwhile, the
FTSE All-Share Index total return was +13.0% (in sterling terms).

For the most part, healthcare stocks traded in-line with broader indices
throughout the financial year. However, with geopolitical tensions increasing
as the financial year drew to a close alongside a rising interest rate
environment, healthcare benefitted as investors became decisively more
defensive in the last five weeks of the period. As such, the MSCI World
Healthcare Index net total return over the year was +20.4% (in sterling
terms), with over half of that move accruing in the last 27 trading days of
the financial year.

PERFORMANCE

After one of the best performance years in the Company’s history in the year
ended 31 March 2021, generating excess returns over the benchmark in the
current financial year proved to be very difficult. Whilst healthcare stocks
mostly traded higher, trading dynamics for the Company were broadly fuelled by
macro factors, with industry and company fundamentals firmly taking a backseat
and going largely unrecognised by investors. As a result, sub-sector moves
within healthcare were very disparate given the “growth-to-value” rotation
and the risk-off environment that characterised the reported year.

This trading environment heavily favoured large capitalisation companies over
small capitalisation stocks, thus, overall positioning within healthcare
equities was far more critical than stock selection. This was particularly
true for the Company’s portfolio, with our key long-term strategic
overweight positions in emerging biotechnology, China healthcare, and
innovative tools – typically all small capitalisation stocks – materially
underperforming. This included in historic drawdowns and record setting
underperformance in emerging biotechnology stocks which severely impacted
returns, despite an otherwise healthy fundamental sector. This was exacerbated
by our long-term underweight positioning in pharmaceuticals – typically all
large capitalisation stocks – a sector that outperformed the rest of
healthcare, particularly during the last quarter of the financial year.

Overall, our performance was heavily impacted by this relative positioning as
the preponderance of fundamentals across healthcare failed to influence
trading dynamics; a true mismatch to our investment philosophy. Rather, this
extraordinary market perturbation created not only extreme volatility but also
an historic compression of valuations within certain components of healthcare,
a situation that would expectedly be damaging to our relative portfolio
positioning. As a result, relative and absolute performance suffered with a
net asset value total return of -5.8%, and a share price total return of
-10.8%, compared to the benchmark index total return of +20.4%.

Despite the volatility in the reported period, we are pleased to note that
since the Company’s inception in 1995, the total return of the Company’s
net asset value per share is +3,866.7%, equivalent to a compound annual return
of +14.7%. This compares to the blended benchmark rise of +2,133.6%,
equivalent to a compound annual return of +12.2%.

This 27-year track record demonstrates several important points. First, it
puts into context the recent drawdown. Previous periods of underperformance by
the Company have all been quickly followed by a significant bounce back and
material outperformance. Second, the chart above shows outperformance for
healthcare (the benchmark) versus the broader markets (in this case, the FTSE
All-Share Index), particularly over the past seven years which coincides with
the real explosion of innovation within the industry. Finally, it shows what
an active manager or specialist investor can do in healthcare, especially in
the face of a highly idiosyncratic, global sector that possesses many barriers
to understanding the scientific, clinical, regulatory, technological, and
political environment that envelops all of healthcare.

Finally, we would note that the fundamentals of healthcare remain strong,
especially in biotechnology, which we regard as the cradle of innovation for
clinical discovery.

The macro trading dynamics that impacted these stocks in the reported period
do not represent, in any way, a deterioration of the elements that underpin
the sector. Rather, it is simply a product of extreme market conditions that
we have never experienced previously, culminating in a profound collapse in
valuations, a situation that should reverse in due time. With fundamentals
intact, we remain positioned for a material rebound in biotechnology stocks.

CONTRIBUTION BY SUB-SECTOR

Looking at performance by sub-sector provides an understanding of overall
performance during the year. First, four areas which contributed a significant
absolute positive contribution were Pharmaceuticals (benefitting from a macro
defensive rotation), Medical Devices/ Technology (a result of stock picking),
Healthcare Services (reflecting our sector positioning), and India.

Healthcare (again, as a result of stock picking). Second, four sub-sectors
that contributed a notable relative positive contribution over the benchmark
were Specialty Pharmaceuticals, Medical Devices/Technology, India Healthcare
(all reflecting the results of stock-picking) and Japan Pharmaceuticals
(reflecting our sector positioning).

However, detractors from performance overwhelmed the positive contributions.
The following three sub-sectors were notable in terms of both relative and
absolute negative contribution - emerging biotechnology (reflecting macro
sector rotation), China healthcare (a result of fundamental investor
concerns), and small/mid-capitalisation life science tools/diagnostics
(reflecting our overweight sector positioning). Each of these sub-sectors
experienced significant drawdowns during the year creating a headwind to the
Company’s performance that became insurmountable during the reported
12-month period.

The largest detractor by sub-sector was emerging biotechnology stocks, which
generated over 11% of negative contribution (both in absolute and relative
terms). A “perfect storm” of macro factors led to this disappointing
performance. The financial year began with a rotation by investors from growth
to value stocks, as generalist investors repositioned portfolios to gain
exposure to economically sensitive sectors that would benefit most from a
post-COVID reopening of the economy. Biotechnology underperformed during this
period, as did many other growth sectors to which investors had allocated
capital during the COVID pandemic. Many of the shorter-term investors who did
not regularly invest in the biotechnology sector, but who were temporarily
attracted to the industry’s defensive nature and COVID-related research,
appeared to exit the sector.

In the second half of the financial year, increasing concerns about the U.S.
Federal Reserve’s plans to raise interest rates to combat inflation led to
continued weakness in technology stocks, especially those earlier-stage
enterprises which are not expected to realise earnings for many years. This
trend was especially damaging to small capitalisation biotechnology
performance and those stocks sold off even further. Overall, these
macroeconomic and related factors created the longest and largest drawdown in
biotechnology history, with the gap between the S&P Biotechnology ETF (XBI)
compared to the S&P 500 Index reaching over 65% during the financial year.

Adding pressure to the Company’s performance was a significant drawdown in
the Chinese markets, including Hong Kong, in the second half of the financial
year. The sell-off was precipitated by regulatory tightening by the Chinese
government across a variety of sectors, including the internet (and related
technology industries) and the for-profit education industry. Even though
there were no new significant regulations targeting Chinese healthcare
companies, investor fears were materially heightened that healthcare may be
the government’s next target. This broad market downturn in China that began
in June 2021 adversely and indiscriminately impacted many of our China
healthcare positions. Unfortunately, these macro pressures persisted through
to the end of the financial year, generating nearly 4% of negative absolute
and relative contribution in the reported period. Importantly, we continue to
believe fundamental innovation in the China healthcare sector remains strong.

The life science tools sector was also challenging for the Company in the year
under review. Mirroring the broader market, large capitalisation diversified
companies significantly outperformed those with a small and mid-capitalisation
innovative growth profile, and our positioning in this regard was suboptimal,
resulting in over 5% of negative contribution relative to the benchmark.
Additionally, there were fundamental factors that drove this large
capitalisation outperformance – chief among which was the continued
durability of COVID-related revenues as well as a normalisation of non-COVID
“base business” performance which led to positive earnings revisions
throughout the 2021 calendar year. Our view that the durability of COVID
related earnings would come into question amid record high valuations was
clearly too early. Whilst we did have modest exposure to Thermo Fisher
Scientific and Danaher Corporation, two companies which benefited from these
dynamics and offer best-in-class execution, we had lower exposure than our
benchmark which damaged our relative performance.

Separately, our preferred small and mid-capitalisation companies in the
innovative tools space weighed on our performance. Whilst we have a positive
structural outlook on liquid biopsy and the continued proliferation of
clinically successful oncology diagnostics, the sector fell out of favour
against the backdrop of demanding valuations and fundamental results that were
strong but were insufficient to drive shares higher against lofty near-term
expectations.

Finally, a word on the performance of large capitalisation pharmaceutical
stocks in the financial year. As articulated already in this report,
pharmaceutical stocks traded mostly in-line with the benchmark throughout the
period.

However, as we approached the turn of the calendar year, this performance
began to diverge materially as inflation, interest rates, and geopolitical
risks all rose and investors turned defensive. As a result, large
capitalisation pharmaceutical stocks moved much higher heading into the
financial year end, many of which ended on 52-week highs on 31 March 2022.
This created the single largest source of absolute contribution for the
Company at over 7%. However, as is our historical norm, we were materially
underweight in the pharmaceutical sector in the period, thus creating over
5.0% of negative relative contribution to the benchmark due to our
positioning.

KEY CONTRIBUTORS TO PERFORMANCE

There were a number of factors that underlay the key positive contributors to
absolute performance. These included the beneficiaries of the macro factors
described above, such as the outperformance of large capitalisation stocks,
alongside a mix of positive fundamentals that also influenced share price
moves. OrbiMed prides itself on its expertise within clinical medicine and how
that capability helps shape good stock picking within the healthcare sector.

A prototypical example of this combination of macro tailwinds and good stock
picking was AbbVie. Over the past two years, the company has been in the midst
of a transformation. Facing the largest patent expiration in industry history
–Humira, with peak global sales of U.S.$20 billion – the company has
re-invented its immunology franchise with newer, better, and safer drugs in
Skyrizi (injectable risankizumab) and Rinvoq (oral upadacitinib), two drugs
approved to treat a variety of immunological disorders.

Investor optimism hit a nadir in September 2021 when the U.S. Food and Drug
Administration (FDA) communicated their general concern over the safety of all
oral JAK inhibitors (Janus Kinase inhibitors, the class of medicines included
Rinvoq), certainly delaying and perhaps denying future additional approvals
for Rinvoq, largely considered the “best-in-class” JAK inhibitor in the
world. With the stock on the low after falling further on the news, we added
meaningfully to our position. That risk paid off two-fold. First, despite a
modest delay, the FDA did ultimately approve Rinvoq for Psoriatic Arthritis,
Ulcerative Colitis, and Atopic Dermatitis (in addition to the already approved
Rheumatoid Arthritis), pushing the stock higher. Second, the stock certainly
caught the macro trend towards the start of 2022 when large capitalisation
pharmaceutical stocks moved higher in the face of rising interest rates,
record inflation, and war in Europe.

Another pharmaceutical company that has re-invented itself is AstraZeneca.
After nearly a decade of declining revenues and earnings, the company has
turned itself around under the guidance of CEO Pascal Soriot, creating one the
largest and fastest growing global, multinational pharmaceutical companies in
the world. With leadership in oncology, cardiovascular, respiratory, and more
recently, rare diseases, the company is poised for sustainable, long-term
growth. However, these successes have not been without some angst, as a messy
but well-intended effort to develop a COVID vaccine created some share price
volatility as did the close of the acquisition of Alexion Pharmaceuticals,
which sparked investor fears that the company’s stand-alone financials were
going to disappoint.

However, after a robust fourth quarter report, better than expected guidance
for 2022, and a strong launch for the company’s COVID-19 prophylaxis
injection, Evusheld (tixagevimab co-packaged with cilgavima), AstraZeneca’s
share price closed at an all-time high at the end of the Company’s financial
year.

UnitedHealth Group is the largest health insurer in the United States as well
as one of the largest healthcare services providers through its subsidiary,
Optum. This stock represents another example of a mix of positive fundamentals
and a macroeconomic environment that took the share price to new highs in
2022. Heading into its third quarter 2021 earnings, investors faced
significant fears of whether increasing medical costs and lingering
COVID-related costs (testing, treatment, vaccines) would impede the
insurers’ ability to grow earnings. Additionally, regulatory noise became
louder with prospects of Medicare Advantage, an insurer-run government
programme, would face reimbursement cuts or other challenges to pay for other
priorities in a large U.S. federal spending bill.

However, the company produced strong third and fourth quarter results, along
with better-than-expected earnings guidance for 2022. Meanwhile, political
negotiations over a large spending bill broke down in the U.S., removing
another critical source of risk. Finally, the shifting macroeconomic
landscape, including higher interest rates, rising inflation, and a shift out
of growth stocks into value stocks, all benefited UnitedHealth, which has
since become a “safe haven” in healthcare.

Shanghai Bio-heart Biological Technology is a cardiovascular medical device
startup in China. The company sells two product lines: Renal Denervation (RDN)
and Bioresorbable Vascular Scaffold System (BVS). Together, these technologies
address the unmet medical needs of Chinese patients for the treatment of
coronary and peripheral artery diseases and uncontrolled hypertension.

Bio-heart’s line of RDN products is a “best-in-class” product in China,
with a unique catheter design which is the only one that can be inserted by
both radial artery and femoral artery (unlike the competition). The
company’s RDN business is also backed by Terumo, the Japan-based global
leader in medical technology, in a technology-validating deal. The investment
into Bio-heart was an unquoted investment. The company listed on the Hong Kong
Exchange in December 2021 and the share price more than doubled during the
remainder of the Company’s financial year.

Before the turn of the decade, Bristol-Myers Squibb became one of the most, if
not the most, dominant cancer companies in the world. With pioneering work in
revolutionary field of immuno-oncology in the mid-2010s and the
U.S.$74 billion acquisition of Celgene in 2019, the company possessed
leadership in both the solid tumour and liquid tumour fields of oncology.
However, the company has also become misunderstood. Investor anxiety over the
company’s growth strategy and increased concerns over imminent patent
expirations for key products saw the company’s valuation collapse to an
all-time low, with the shares trading with a price-to-earnings ratio of 7.0x
during the reported period.

However, an analyst meeting hosted by company management in November 2021 in
New York City proved to be a seminal moment in the company’s recent history.
Using that platform, the company provided a deep dive on their pipeline,
discussed growth opportunities, and provided long term growth targets. That
event, combined with the defensive rotation into pharmaceuticals at the
Company’s financial year-end, was a boon to investor interest and the stock
re-rated over 30% (in local currency) over the last four months of the
reported period.

KEY DETRACTORS FROM PERFORMANCE

Mirati Therapeutics is an emerging biotechnology company focused on the
development of therapeutics for the treatment of cancer. The company’s main
pipeline asset, adagrasib, is highly selective and potent oral small molecule
inhibitor of KRAS G12C (a mutation that underlies the formation of a number of
tumours) that is being developed for various cancers, including lung, colon,
and other solid tumours. Despite achieving many development milestones for
adagrasib in the year, including a successful new drug application with the
FDA, the share price was punished, perhaps unduly, for a variety of reasons,
including a stock offering and multiple management changes. Most recently, the
stock was under pressure again after the FDA accepted the filing for adagrasib
but granted a regular review rather than the expected priority review, pushing
the potential approval and launch in 2023.

MIRATI THERAPEUTICS: KRAS INHIBITION

In the diagnostics space, Natera is an industry leader with a host of
innovative offerings including non-invasive prenatal testing (NIPT) and other
genetic testing. While Natera’s commercial execution was strong in the
reported period, the company did not benefit from COVID-testing tailwinds
(unlike the large-capitalisation diagnostic players) and share price declines
were further exacerbated by the growth-to-value rotation that characterised
the year under review. Additionally, the New York Times published an article
in January 2022 denouncing the low accuracy of NIPT in identifying rare
genetic diseases, and in March 2022, a short seller published a report on
Natera alleging illegal billing practices relating to its NIPT business, both
of which created significant controversy. Whilst we disagreed with both of
these reports, these collective issues created a significant disconnect
between the company’s fundamentals and most recent valuation.

NATERA: NIPT

Another innovative player in the diagnostics space is Guardant Health, an
oncology diagnostics company that has emerged as the pre-eminent liquid biopsy
provider. The company has many offerings in the cancer diagnostics sector
including therapy selection, disease assays, and response monitoring. The
company also plans to enter the non-invasive screening market in 2022.
Unfortunately, the share price experienced a material pullback through the
course of the year despite generally strong financial performance. Again,
macro-market conditions were largely to blame, but the stock was particularly
weak following rumours that it was considering a purchase of another oncology
diagnostics company, although the deal never materialised. Again, these
collective issues created a significant disconnect between the company’s
fundamentals and its most recent valuation.

Deciphera Pharmaceuticals, is a clinical stage, emerging biotechnology company
that is developing small molecule drugs to treat various types of cancer. The
company’s focus in recent years has been the continued development of
Qinlock (ripretinib), an orally administered inhibitor of specific mutated
kinases which otherwise contribute to the development of certain cancers. In
2020, the FDA approved Qinlock for use as a fourth line therapy for
gastrointestinal stromal tumours (GIST). More recently, the company conducted
a trial to explore the use of Qinlock in earlier lines of therapy. However, in
November 2021, that trial failed to show significantly superior results versus
the standard of care in second line GIST, Sutent (sunitinib). The stock had
traded down along with the broader biotechnology drawdown into this update and
subsequently gapped even lower after the failed trial.

The “XBI” is an exchange-traded fund - SPDR S&P Biotech ETF - incorporated
in the U.S. that seeks to replicate the performance of the S&P Biotechnology
Index. The Index is equal-weighted, has approximately 150 constituents, and
tracks all biotechnology single stocks that are listed on the NYSE, American
Stock Exchange, and the NASDAQ National Market and Small Capitalisation
exchanges. The XBI offers an opportunity to gain tactical exposure to the
biotechnology subsector quickly and efficiently while not exposing the
portfolio to unnecessary idiosyncratic single stock risks. Given the
extraordinary drawdown in the biotechnology subsector since February 2021, the
removal of key sector overhangs, and anticipated mergers & acquisitions (M&A)
by large capitalisation pharmaceutical companies, we wanted to gain exposure
to a tactical rebound as we went through the year. Unfortunately, our purchase
was premature, and the XBI continued to sell off right into the financial
year-end. This holding was bought and sold during the year.

CONTRIBUTION FROM UNQUOTEDS

During the financial year, the Company made four new investments in unquoted
companies. Another four portfolio companies – including one of these new
investments – completed their Initial Public Offerings (IPOs) in the period.
As of 31 March 2022, investments in unquoted companies (excluding debt)
accounted for 7.0% of the Company’s net assets versus 5.3% as of 31 March
2021.

The four new investments this year were all healthcare services companies in
emerging markets (one in India and three in China). In the U.S., a challenging
public offering market for small and mid-capitalisation therapeutics companies
made pre-IPO crossover investments unattractive in the year. Of the four
companies that completed an Initial Public Offering, three listed on the Hong
Kong Stock Exchange in the second half of the financial year and a
biotechnology company listed on the Nasdaq Stock Exchange in the U.S.

For the year ended 31 March 2022, the Company’s unquoted holdings
contributed gains of £21.8m, (including both realised and unrealised gains)
equivalent to a return of 15% and those companies that went public contributed
gains of £20.7m, representing a return of 35%. While the gains in unquoteds
were spread among many companies, the gains for companies that listed were
dominated by Shanghai Bio-heart Biological Technology. Overall, the unquoted
strategy (excluding debt) contributed £42.5m equivalent to 1.8% of the
Company’s net asset value return for the year.

GEARING STRATEGY

The Company employs gearing with a maximum level of 20% of the Company’s net
assets. Historically, the typical gearing level employed by the Company is
low-to-high teens but can range from low single-digits to high teens.
Considering the level of market volatility during the past two financial
years, the use of gearing has evolved. First, the over level of gearing used
– on average – has declined from 9% (5 year average) to 6% (2 year
average). Second, month-over-month gearing levels have also varied more than
historical norms as we have attempted to utilise gearing in a more tactical
fashion and in response to various market conditions.

DERIVATIVES STRATEGY

The Company has the ability to use equity swaps and options, as set out in the
Company’s Investment Objective and Policy. During the current financial
year, the Company employed single stock equity swaps to gain exposure to
emerging market Chinese and Indian stocks. In addition, the Company traded
tactical security baskets created to take advantage of depressed valuations in
small and mid-capitalisation companies that we felt were likely acquisition
targets for large capitalisation pharmaceutical companies. The equity swaps
detracted 0.9% from the Company’s return during the year. An analysis of the
Company’s investments in emerging markets is included in the Strategic
Report.

Further details on the use of swaps can be found in Note 16 and in the
Glossary.

SECTOR DEVELOPMENTS & OUTLOOK

Overall, we remain positive on the outlook for the healthcare industry.
Despite the mixed trading dynamics during the financial year, many immediate
overhangs have lifted and the tailwinds remain strong, in particular the
amount of innovation that is fuelling the industry’s growth, both in
therapeutic and non-therapeutic stocks.

On the regulatory front, there has been a growing concern from generalist
investors that things have slowed significantly at the FDA and that there is a
vacuum of leadership at the Agency. This view began to develop in 2020 with
the absence of a Commissioner (typically appointed when there is a change in
U.S. Presidents) and when agency resources where stretched given the COVID-19
pandemic. However, we have a very different view.

First, the FDA response to COVID-19 has been an unprecedented success with
multiple vaccines approved, multiple antibody treatments approved, and more
recently, two oral anti-viral therapies approved as well. We would also be
remiss not to mention the hundreds of diagnostic tests that have also been
approved by the agency. Second, we have not seen a material slowdown in new
drug approvals. In fact, the past five years have been the most productive in
the agency’s history, including this past year. This included an
Alzheimer’s drug that was approved in June 2021 – the first new treatment
approved for Alzheimer’s disease in over 20 years (albeit with some
controversy).

Finally, and perhaps most importantly, there was a growing concern that the
FDA was “rudderless” since the Agency has been without a commissioner over
that past two years (since President Biden took office). Whilst this belief
was mostly baseless, nevertheless, a new commissioner was just recently
confirmed. Dr. Robert Calif, a world-renowned cardiologist from Duke
University, was the previous Commissioner under President Obama, and most
importantly, is viewed as “industry friendly.” Going forward, we think
investor perception of the FDA is going to improve immensely in 2022 and
beyond.

Another dark cloud over the sector is the ongoing (and seemingly endless)
threat of prescription drug price reform in the U.S. This fear has been an
overhang on the Company since late 2020, when President Biden took the White
House and Democrats had total control of Congress, setting off a new
“wall-of-worry” for investors. However, with war breaking out in Eastern
Europe, the Biden Administration’s attention has pivoted and is now
completely focused on other matters. Therefore, we believe that expectations
for any drug price reform have now appropriately faded, especially as we
approach U.S. midterm elections later in 2022.

Historically, the healthcare industry is one that sees a significant amount of
corporate activity, frequently in the form of M&A and this M&A activity has
been a notable source of positive performance for the Company. Of course,
there are always ebbs and flows that impact the pace of M&A at any one time,
but the last two quarterly reporting periods have been notable for the
profound messaging from the large capitalisation pharmaceutical executives
about business development, particularly about M&A being a “top priority”,
the need to “do more”, and looking to add “first-in-class and
best-in-class” assets. Overall, this may be a harbinger of things to come
and could be a real rallying point, especially in the biotechnology sector.

M&A: ACCELERATION EXPECTED

Given the historic volatility within the sector in the reported period, it is
imperative to note that this extreme sell-off was not emblematic of any
notable concerns about the fundamentals within the small and
mid-capitalisation universe of healthcare stocks. Yes, the number of
investable companies continues to increase. Yes, the complexity of the
clinical science and new technology continues to increase. Yes, the political
and regulatory landscape continue to evolve. Collectively, however, these
factors can become a tailwind for the sector as new products, drugs, and
services come to market, driving top line growth and margins, respectively.
The by-product of the broad market conditions has culminated in a profound
collapse in valuations, a situation that invariably reverses in due time, a
particular attractive opportunity for an active manager and specialist
healthcare investor, and one on which we will be in position to capitalise.

Ultimately, as with many modern industries, innovation is the key value driver
and healthcare is no different. We continue to believe that the current pace
of innovation is at an all-time high and will continue to develop novel
solutions to solve health and ageing problems that are facing all of humanity.
There are new advances for small molecules, gene and cell therapy, gene
editing, monoclonal antibodies, and of course vaccines and RNA therapeutics.
Novel diagnostics continue to progress and are shaping treatment choices,
dictating drugs of intervention, and follow-up care. Medical devices continue
to evolve across new robotic platforms, orthopedics, pain, and structural
heart. Even managed care is seeing a revolution in vertical integration that
is unlocking value. Innovation continues to be the number one growth driver
for all of healthcare and remains a key hallmark of the portfolio. As a result
of this view, we will continue to actively position the portfolio to benefit
from this incredible innovation, overweighting innovation through small and
mid-capitalisation stocks, which has been the key pillar of our long-term and
successful investment strategy.

Sven H. Borho and Trevor M. Polischuk

OrbiMed Capital LLC

Portfolio Manager

26 May 2022

CONTRIBUTION BY INVESTMENT

ABSOLUTE CONTRIBUTION BY INVESTMENT FOR THE YEAR ENDED 31 MARCH 2022

Principal contributors to and detractors from net asset value performance

                                                                                                    Contribution 
                                                                                      Contribution    per share* 
 Top five contributors                     Country                            Sector         £’000             £ 
 Abbvie                                    USA                       Pharmaceuticals        43,658           0.7 
 AstraZeneca                               UK                        Pharmaceuticals        39,516           0.6 
 UnitedHealth Group                        USA       Healthcare Providers & Services        29,254           0.4 
 Shanghai Bio-Heart Biological Technology  China     Healthcare Equipment & Supplies        24,934           0.4 
 Bristol-Myers Squibb                      USA                       Pharmaceuticals        24,633           0.4 

   

 Top five detractors                                                                 
 SPDR S&P Biotech ETF **       USA                    Biotechnology  (26,637)  (0.4) 
 Deciphera Pharmaceuticals **  USA                    Biotechnology  (32,923)  (0.5) 
 Guardant Health               USA   Life Sciences Tools & Services  (34,062)  (0.5) 
 Natera                        USA   Life Sciences Tools & Services  (35,122)  (0.5) 
 Mirati Therapeutics           USA                    Biotechnology  (45,742)  (0.7) 
* Calculation based on 65,307,132 shares being the weighted average number of
shares in issue during the year ended 31 March 2022.
* Not held at 31 March 2022.
ENVIRONMENTAL, SOCIAL AND GOVERNANCE AND CLIMATE CHANGE

EXTRACT FROM ORBIMED’S RESPONSIBLE INVESTING POLICY

The Company’s Portfolio Manager, OrbiMed, believes that there is a high
congruence between companies that seek to act responsibly and those that
succeed in building long-term shareholder value. OrbiMed seeks to integrate
its Responsible Investing Policy into its overall investment process for the
Company in order to maximise investment returns.

OrbiMed negatively screens potential investments and business sectors that may
objectively lead to negative impacts on public health or well-being. OrbiMed
makes investment decisions based on a variety of financial and non-financial
company factors, including environmental, social and governance (ESG)
information.

OrbiMed considers sector-specific guidance from the Sustainability Accounting
Standards Board (SASB) to determine material ESG factors. Depending on the
investment, all or a subset of the ESG factors that are financially material
and relevant are considered in OrbiMed’s research. The evaluation of a
company’s performance on ESG issues provides guidance for investment
decisions and constitutes part of the investment analysis. ESG factors,
however, do not form the sole, or primary, set of considerations for an
investment decision.

ESG is a rapidly evolving field. ESG evaluation is not standardised and faces
limitations due to a lack of availability of accurate, timely and uniform
data. Presently, no known universally accepted standards for ESG incorporation
in investment decisions exist. Therefore, ESG evaluation carries a significant
degree of subjectivity.

ESG MONITORING

OrbiMed has integrated ESG scores for public equity holdings from third-party
service providers onto its platform via programming interface. ESG scores are
assigned by third-party service providers to each company based on the
company’s disclosure and practice on material environmental, social and
governance factors. Recognising the need to supplement the scores with
OrbiMed’s internal ESG research, OrbiMed has enabled enhancements in its
monitoring capability with a custom-built protocol for updating these scores.

OrbiMed is taking the initiative in leading meaningful ESG engagement in the
healthcare sector. As part of these efforts, OrbiMed facilitates dialogues and
an exchange of leading practices among investors, companies and other relevant
experts on ESG in the large capitalisation pharmaceutical sector.

CLIMATE CHANGE

As per the guidance from SASB, climate change in relation to the Company’s
own operations is not a material ESG consideration for biotechnology and
pharmaceutical, medical equipment and supplies, and managed care sectors.
However, Energy management is noted as a material ESG concern for the
healthcare delivery sector. To that end, OrbiMed includes the scores on energy
management for the relevant sectors in its overall ESG monitoring.

OrbiMed engages with a number of companies, including one-on-one meetings with
management on ESG, analyst calls and other forums. For example, OrbiMed held a
meeting with Horizon Therapeutics on leading ESG practices and provided
feedback and recommendations on specific ESG topics such as talent management,
disclosure and governance benchmarks to the company. Through these
engagements, OrbiMed was made aware of the ‘Energize’ programme – a
collaborative programme launched by 10 pharmaceutical companies – including
several OrbiMed portfolio companies – to increase access to renewable
electricity for global pharmaceutical supply chains, and reduce greenhouse gas
(GHG) emissions within the healthcare supply chain.

OrbiMed generally follows the guidelines and recommendations of Glass Lewis &
Co LLC, a leading proxy voting services provider, including on climate change
matters.

Sven H. Borho and Trevor M. Polischuk

OrbiMed Capital LLC

Portfolio Manager

26 May 2022

BUSINESS REVIEW

The Strategic Report, contains a review of the Company’s business model and
strategy, an analysis of its performance during the financial year and its
future developments and details of the principal risks and challenges it
faces.

Its purpose is to inform shareholders in the Company and help them to assess
how the Directors have performed their duty to promote the success of the
Company. Further information on how the Directors have discharged their duty
under s172 of the Companies Act 2006 in promoting the success of the Company
for the benefit of the investors as a whole, and how they have taken wider
stakeholders’ needs into account can be found in the Strategic Report. The
Strategic Report contains certain forward-looking statements. These statements
are made by the Directors in good faith based on the information available to
them up to the date of this report. Such statements should be treated with
caution due to the inherent uncertainties, including both economic and
business risk factors, underlying such forward-looking information.

BUSINESS MODEL

Worldwide Healthcare Trust PLC is an externally managed investment trust and
its shares are listed on the premium segment of the Official List and traded
on the main market of the London Stock Exchange.

As an externally managed investment trust, all of the Company’s day-to-day
managements and administrative functions are outsourced to service providers.
As a result, the Company has no executive directors, employees or internal
operations. The Company employs Frostrow Capital LLP (Frostrow) as its
Alternative Investment Fund Manager (AIFM), OrbiMed Capital LLC (OrbiMed) as
its Portfolio Manager, J.P. Morgan Europe Limited as its Depositary and J.P.
Morgan Securities LLC as its Custodian and Prime Broker. Further details about
their appointments can be found in the Business Review. The Board has
determined an investment policy and related guidelines and limits, as
described below.

The Company is an investment company within the meaning of Section 833 of the
Companies Act 2006 and has been approved by HM Revenue & Customs as an
investment trust (for the purposes of Section 1158 of the Corporation Tax Act
2010). As a result the Company is not liable for taxation on capital gains.
The Directors have no reason to believe that approval will not continue to be
retained. The Company is not a close company for taxation purposes.

The Board is responsible for all aspects of the Company’s affairs, including
the setting of parameters for and the monitoring of the investment strategy a
s well as the review of investment performance and policy. It also has
responsibility for all strategic issues, the dividend policy, the share
issuance and buy-back policy, gearing, share price and discount/premium
monitoring and corporate governance matters.

CONTINUATION OF THE COMPANY

A resolution was passed at the Annual General Meeting held in 2019 that the
Company continues as an investment trust for a further five year period. In
accordance with the Company’s Articles of Association, shareholders will
have an opportunity to vote on the continuation of the Company at the Annual
General Meeting to be held in 2024 and every five years thereafter.

THE BOARD

The Board of the Company comprises Sir Martin Smith (Chairman), Sarah Bates,
Sven Borho, Doug McCutcheon, Dr Bina Rawal and Humphrey van der Klugt. All of
these Directors, served throughout the year. All are independent non-executive
Directors with the exception of Mr Borho who is not considered to be
independent by the Board.

All Directors, with the exception of Sir Martin Smith, are seeking re-election
by shareholders at this year’s Annual General Meeting.

DIVIDEND POLICY

It is the Company’s policy to pay out dividends to shareholders at least to
the extent required to maintain investment trust status for each financial
year. Such dividends will typically be paid twice a year by means of an
interim dividend and a final dividend.

KEY PERFORMANCE INDICATORS (‘KPI’)

The Board assesses the Company’s performance in meeting its objectives
against key performance indicators as follows. The Key Performance Indicators
have not changed from the previous year:
* Net asset value (‘NAV’) per share total return against the Benchmark;*
* Discount/premium of share price to NAV per share;* and
* Ongoing charges ratio.*
Information on the Company’s performance is provided in the Chairman’s
Statement and the Portfolio Manager’s Review. Further information can be
found in the Glossary.

*          Alternative Performance Measure (See Glossary)

NAV per share total return against the benchmark

The Directors regard the Company’s NAV per share total return as being the
overall measure of value delivered to shareholders over the long term. This
reflects both net asset value growth of the Company and dividends paid to
shareholders.

The Board considers the most important comparator, against which to assess the
NAV per share total return performance, to be the MSCI World Health Care Index
measured on a net total return, sterling adjusted basis (the ‘Benchmark’).
OrbiMed has flexibility in managing the investments and are not limited by the
make up of the Benchmark. As a result, investment decisions are made that
differentiate the Company from the Benchmark and therefore the Company’s
performance may also be different to that of the Benchmark.

A full description of performance during the year under review is contained in
the Portfolio Manager’s Review.

Share price discount/premium to nav per share

The share price discount/premium to NAV per share is considered a key
indicator of performance as it impacts the share price total return of
shareholders and can provide an indication of how investors view the
Company’s performance and its Investment Objective.

Ongoing charges ratio

The Board continues to be conscious of expenses and works hard to maintain a
balance between good quality service and costs.

PRINCIPAL SERVICE PROVIDERS

The principal service providers to the Company are the AIFM, Frostrow Capital
LLP (Frostrow), the Portfolio Manager, OrbiMed Capital LLC (OrbiMed), the
Custodian and Prime Broker J.P. Morgan Securities LLC, and the Depositary,
J.P. Morgan Europe Limited. Details of their key responsibilities follow and
further information on their contractual arrangements with the Company are
included in the Report of the Directors.

Alternative investment fund manager (AIFM)

Frostrow under the terms of its AIFM agreement with the Company provides,
inter alia, the following services:
* oversight of the portfolio management function delegated to OrbiMed Capital
LLC;
* investment portfolio administration and valuation;
* risk management services;
* marketing and shareholder services;
* share price discount and premium management;
* administrative and secretarial services;
* advice and guidance in respect of corporate governance requirements;
* maintenance of the Company’s accounting records;
* maintenance of the Company’s website;
* preparation and dispatch of annual and half year reports (as applicable) and
monthly fact sheets; and
* ensuring compliance with applicable legal and regulatory requirements.
During the year, under the terms of the AIFM Agreement, Frostrow received a
fee as follows:

On market capitalisation up to £150 million: 0.3%; in the range £150 million
to £500 million: 0.2%; in the range £500 million to £1 billion: 0.15%; in
the range £1 billion to £1.5 billion: 0.125%; over £1.5 billion: 0.075%. In
addition, Frostrow receives a fixed fee per annum of £57,500.

Portfolio manager

OrbiMed under the terms of its portfolio management agreement with the AIFM
and the Company provides, inter alia, the following services:
* the seeking out and evaluating of investment opportunities;
* recommending the manner by which monies should be invested, disinvested,
retained or realised;
* advising on how rights conferred by the investments should be exercised;
* analysing the performance of investments made; and
* advising the Company in relation to trends, market movements and other
matters which may affect the investment objective and policy of the Company.
OrbiMed receives a base fee of 0.65% of NAV and a performance fee of 15% of
outperformance against the Benchmark.

Depositary, custodian and prime broker

J.P. Morgan Europe Limited acts as the Company’s Depositary and J.P. Morgan
Securities LLC as its Custodian and Prime Broker.

J.P. Morgan Europe Limited, as Depositary, must take reasonable care to ensure
that the Company is managed in accordance with the Financial Conduct
Authority’s Investment Funds Sourcebook, the AIFMD and the Company’s
Articles of Association. The Depositary must in the context of this role act
honestly, fairly, professionally, independently and in the interests of the
Company and its shareholders.

The Depositary receives a variable fee based on the size of the Company.

J.P. Morgan Europe Limited has discharged certain of its liabilities as
Depositary to J.P. Morgan Securities LLC. Further details of this arrangement
are set out in the Report of the Directors. J.P. Morgan Securities LLC, as
Custodian and Prime Broker, provides the following services under its
agreement with the Company:
* safekeeping and custody of the Company’s investments and cash;
* processing of transactions;
* provision of an overdraft facility. Assets up to 140% of the value of the
outstanding overdraft can be taken as collateral; and
* foreign exchange services.
AIFM AND PORTFOLIO MANAGER EVALUATION AND RE-APPOINTMENT

The performance of the AIFM and the Portfolio Manager is reviewed continuously
by the Board and the Management Engagement & Remuneration Committee (the
“Committee”) with a formal evaluation being undertaken each year. As part
of this process, the Committee monitors the services provided by the AIFM and
the Portfolio Manager and receives regular reports and views from them. The
Committee also receives comprehensive performance measurement reports to
enable it to determine whether or not the performance objectives set by the
Board have been met. The Committee reviewed the appropriateness of the
appointment of the AIFM and the Portfolio Manager in February 2022 with a
positive recommendation being made to the Board.

The Board believes the continuing appointment of the AIFM and the Portfolio
Manager, is in the interests of shareholders as a whole. In coming to this
decision, it took into consideration, inter alia, the following:
* the quality of the service provided and the depth of experience of the
company management, company secretarial, administrative and marketing team
that the AIFM allocates to the management of the Company; and
* the quality of the service provided and the quality and depth of experience
allocated by the Portfolio Manager to the management of the portfolio and the
long-term performance of the portfolio in absolute terms and by reference to
the Benchmark.
RISK MANAGEMENT

The Board is responsible for the management of risks faced by the Company.
Through delegation to the Audit & Risk Committee, the Board has established
procedures to manage risk, to review the Company’s internal control
framework and establish the level and nature of the principal risks the
Company is prepared to accept in order to achieve its long-term strategic
objective. At least twice a year the Audit Committee carries out a robust
assessment of the principal risks and uncertainties with the assistance of
Frostrow (the Company’s AIFM) identifying the principal risks faced by the
Company. These principal risks and the ways they are managed or mitigated are
detailed on the following pages.

 Principal risks and uncertainties                                                                                                                                                                                                                               Mitigation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 Market risks                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 By the nature of its activities and Investment Objective, the Company’s portfolio is exposed to fluctuations in market prices (from both individual security prices and foreign exchange rates) and due to exposure to the global healthcare sector, it is      To manage these risks the Board and the AIFM have appointed OrbiMed to manage the investment portfolio within the remit of the investment objective and policy, and imposed various limits and guidelines. These limits ensure that the portfolio is diversified, reducing the risks associated with individual stocks, and that the maximum exposure (through derivatives and an overdraft facility) is limited. The compliance with those limits and guidelines is monitored daily by Frostrow and OrbiMed and reported to the Board monthly. In addition, OrbiMed reports at each Board meeting on the performance of the Company’s portfolio, which encompasses the rationale for stock selection decisions, the make-up of the portfolio, potential new holdings and, derivative activity and strategy (further details on derivatives can be found in note 16). The Company does not currently hedge its currency exposure.     
 expected to have higher volatility than the wider market. As such investors should be aware that by investing in the Company they are exposing themselves to market risks and those additional risks specific to the sectors in which the Company invests, such                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 as political interference in drug pricing. In addition, the Company uses leverage (both through derivatives and gearing) the effect of which is to amplify the gains or losses the Company experiences.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 Geo-political/regulatory and macro economic risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 Macro events may have an adverse impact on the Company’s performance by causing exchange rate volatility, changes in tax or regulatory environments, and/or a fall in market prices. Emerging markets, which a portion of the portfolio is exposed to, can be   While such events are outside the control of the Company the Board reviews regularly, and discusses with the Portfolio Manager, the wider economic and political environment, along with the portfolio exposure and the execution of the investment policy against the long-term objectives of the Company. The Portfolio Manager’s risk team perform systematic risk analysis, including country and industry specific risk monitoring. The Board monitors regulatory developments but relies on the services of its external advisers to ensure compliance with applicable law and regulations. The Board has appointed a specialist investment trust AIFM and Company Secretary who provides industry and regulatory updates at each Board meeting. With regard to Brexit, the Board does not believe that it poses a unique risk to the Company or that it will affect the Company’s share price or how its shares are sold.      
 subject to greater political uncertainty and price volatility than developed markets.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 Unquoted investment risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 The Company’s risk could be increased by its investment in unquoted companies. These investments may be more difficult to buy, sell or value, so changes in their valuations may be greater than for listed assets. The valuation of unquoted investments       To mitigate this risk the Board and AIFM have set a limit of 10% of the portfolio, calculated at the time of investment, that can be held in unquoted investments and have established a robust and consistent valuation policy and process as set out in Note 1(b), which is in line with UK GAAP requirements and the International Private Equity and Venture Capital (IPEV) Guidelines. The Board also monitors the performance of these investments compared to the additional risks involved.                                                                                                                                                                                                                                                                                                                                                                                                                                   
 requires considerable judgement as explained in Note1(a) and as such realisations may be materially lower than the value as estimated by the Company. Particular events, outside the control of the Company, may also have a significant impact on the valuation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 and considerable uncertainty may exist around the potential future outcomes for each investment.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 Investment management key person risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 There is a risk that the individuals responsible for managing the Company’s portfolio may leave their employment or may be prevented from undertaking their duties.                                                                                             The Board manage this risk by:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 Counterparty risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 In addition to market and foreign currency risks, discussed above, the Company is exposed to risk arising from the use of counterparties. If a counterparty were to fail, the Company could be adversely affected through either delay in settlement or loss of This risk is managed by the Board through:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 assets. The most significant counterparty the Company is exposed to is J.P. Morgan Securities LLC which is responsible for the safekeeping of the Company’s assets and provides the overdraft facility to the Company. As part of the arrangements with J.P.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
 Morgan Securities LLC they may take assets, up to 140% of the value of the drawn overdraft, as collateral and have first priority security interest or lien over all of the Company’s assets. Such assets taken as collateral may be used, loaned, sold,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 rehypothecated or transferred by J.P. Morgan Securities LLC. Although the Company maintains the economic benefit from the ownership of those assets it does not hold any of the rights associated with those assets. Any of the Company’s assets taken as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 collateral are not covered by the custody arrangements provided by J.P. Morgan Securities LLC. The Company is, however, afforded protection in accordance with SEC rules and U.S. legislation equal to the value of the assets that have been rehypothecated.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 Service provider risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 The Board is reliant on the systems of the Company’s service providers and as such disruption to, or a failure of, those systems could lead to a failure to comply with law and regulations leading to reputational damage and/ or financial loss to the        To manage these risks the Board:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 Company. The spread of an infectious disease, such as has been seen as a result of the COVID-19 pandemic, may again force governments to introduce rules to restrict meetings and movements of people and take other measures to prevent its spread, which may                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 cause disruption to the Company’s operations.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 ESG related risks                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 Both the Board and the Portfolio Manager recognise the importance of having a coherent ESG policy. There is a risk that investing in companies that disregard ESG factors will have a negative impact on investment returns and also that the Company itself may The Board ensures that the Portfolio Manager’s ESG approach is in line with standards elsewhere and the Board’s expectations. A summary of the Portfolio Manager’s approach to Responsible Investing can be found in the Strategic Report..                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
 become unattractive to investors if ESG is not appropriately considered in the Portfolio Manager’s decision making process. In light of this, the Board has asked OrbiMed to provide ESG reports at each Board meeting, highlighting examples where ESG issues                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 influenced investment decisions and/or led to engagement with an investee company.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 Shareholder relations and share price performance risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 The Company is also exposed to the risk, particularly if the investment strategy and approach are unsuccessful, that the Company may underperform resulting in the Company becoming unattractive to investors and a widening of the share price discount to NAV In managing this risk the Board: The operation of the discount/premium control mechanism and Company promotional activities have been delegated to Frostrow, who report to the Board at each Board meeting on these activities.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 per share. Also, falls in stock markets, such as those experienced as a consequence of the COVID-19 pandemic, and the risk of a global recession, are likely to adversely affect the performance of the Company’s investments.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        

Emerging risks

The Company has carried out a robust assessment of the Company’s emerging
and principal risks and the procedures in place to identify emerging risks are
described below. The International Risk Governance Council definition of an
‘emerging’ risk is one that is new, or is a familiar risk in a new or
unfamiliar context or under new context conditions (re-emerging). Failure to
identify emerging risks may cause reactive actions rather than being proactive
and, in worst case, could cause the Company to become unviable or otherwise
fail or force the Company to change its structure, objective or strategy.

The Audit and Risk Committee reviews a risk map at its half-yearly meetings.
Emerging risks are discussed in detail as part of this process and also
throughout the year to try to ensure that emerging (as well as known) risks
are identified and, so far as practicable, mitigated.

COVID-19

The Board recognises that the spread of new coronavirus (COVID-19) strains
represents an area of continuing risk, both to the Company’s investments,
investment performance and to its operations. The Portfolio Manager has
continued its dialogue with investee companies and the Board has stayed in
close contact with both the AIFM and the Portfolio Manager and has been
regularly monitoring portfolio and share price developments. The Board has
also received assurances from all of the Company’s service providers in
respect of:
* their business continuity plans and the steps being taken to guarantee the
ongoing efficiency of their operations while ensuring the safety and
well-being of their employees;
* their cyber security measures including improved user-access controls, safe
remote working and evading malicious attacks; and
* any increased risks of fraud resulting from weaknesses in systems user
access controls.
As the rate of vaccinations increases across the world, the outlook is
cautiously positive, but the Board will continue to monitor developments as
they occur.

COMPANY PROMOTION

The Company has appointed Frostrow to provide marketing and investor relations
services, in the belief that a well-marketed investment company is more likely
to grow over time, have a more diverse and stable shareholder register and
will trade at a superior rating to its peers.

Frostrow actively promotes the Company in the following ways:

Engaging regularly with institutional investors, discretionary wealth managers
and a range of execution-only platforms: Frostrow regularly talks and meets
with institutional investors, discretionary wealth managers and execution-only
platform providers to discuss the Company’s strategy and to understand any
issues and concerns, covering both investment and corporate governance
matters. Such meetings have been conducted on a virtual basis during the
COVID-19 pandemic;

Making Company information more accessible: Frostrow works to raise the
profile of the Company by targeting key groups within the investment
community, holding annual investment seminars, overseeing PR output and
managing the Company’s website and wider digital offering, including
Portfolio Manager videos and social media;

Disseminating key Company information: Frostrow performs the Investor
Relations function on behalf of the Company and manages the investor database.
Frostrow produces all key corporate documents, distributes monthly Fact
Sheets, Annual Reports and updates from OrbiMed on portfolio and market
developments; and

Monitoring market activity, acting as a link between the Company, shareholders
and other stakeholders: Frostrow maintains regular contact with sector broker
analysts and other research and data providers, and conducts periodic investor
perception surveys, liaising with the Board to provide up-to-date and accurate
information on the latest shareholder and market developments.

DISCOUNT CONTROL MECHANISM (DCM)

The Board undertakes a regular review of the level of discount/premium and
consideration is given to ways in which share price performance may be
enhanced, including the effectiveness of marketing, share issuance and share
buy-backs, where appropriate.

The Board implemented the DCM in 2004. This established a target level of no
more than a 6% share price discount to the cum-income NAV per share.

Under the DCM, when the discount reaches a level of 6% or more, the
Company’s shares may be bought back and held as treasury shares (See
Glossary).

Treasury shares can be sold back to the market at a later date at a premium to
the cum-income net asset value per share.

Shareholders should note, however, that it remains possible for the share
price discount to the NAV per share to be greater than 6% on any one day. This
is due to the fact that the share price continues to be influenced by overall
supply and demand for the Company’s shares in the secondary market. The
volatility of the NAV per share in an asset class such as healthcare is
another factor over which the Board has no control.

In recent years the Company’s successful performance has generated
substantial investor interest. Whenever there are unsatisfied buying orders
for the Company’s shares in the market, the Company has the ability to issue
new shares at a small premium to the cum income NAV per share. This is an
effective share price premium management tool.

Details of share issuance and share buy-backs are set out in the Report of the
Directors.

SOCIAL, ECONOMIC AND ENVIRONMENTAL MATTERS

The Directors, through the Company’s Portfolio Manager, encourage companies
in which investments are made to adhere to best practice with regard to
corporate governance. In light of the nature of the Company’s business there
are no relevant human rights issues and the Company does not have a human
rights policy.

The Company recognises that social and environmental issues can have an effect
on some of its investee companies.

The Company is an investment trust and so its own direct environmental impact
is minimal. As an externally- managed investment trust, the Company does not
have any employees or maintain any premises, nor does it undertake any
manufacturing or other physical operations itself. All its operational
functions are outsourced to third party service providers. Therefore, the
Company has no material, direct impact on the environment or any particular
community and the Company itself has no environmental, human rights, social or
community policies. The Board of Directors consists of six Directors, four of
whom are resident in the UK, one in Canada and one in the U.S. The Board holds
the majority of its regular meetings in the U.K., with usually one meeting
held each year in New York, and has a policy that travel, as far as possible,
is minimal, thereby minimising the Company’s greenhouse gas emissions.
Further details concerning greenhouse gas emissions can be found within the
Report of the Directors. During the Pandemic all of the Board and Committee
meetings were held via video conference. Video conferencing has proved to be a
very effective way of holding meetings, and this medium will continue to be
used alongside in person meetings.

The Portfolio Manager engages with the Company’s underlying investee
companies in relation to their corporate governance practices and the
development of their policies on social, community and environmental matters.
The Portfolio Manager’s Responsible Investing Policy can be seen below.

TASKFORCE FOR CLIMATE-RELATED FINANCIAL DISCLOSURES (“TCFD”)

The Company notes the TCFD recommendations on climate-related financial
disclosures. The Company is an investment trust with no employees, internal
operations or property and, as such, it is exempt from the Listing Rules
requirement to report against the TCFD framework.

LONG TERM VIABILITY

The Board has carried out a robust assessment of the principal risks facing
the Company including those that would threaten its business model, future
performance, solvency or liquidity. The Board has drawn up a matrix of risks
facing the Company and has put in place a schedule of investment limits and
restrictions, appropriate to the Company’s investment objective and policy,
in order to mitigate these risks as far as practicable. The principal risks
and uncertainties which have been identified, and the steps taken by the Board
to mitigate these as far as possible, are shown in the Strategic Report.

The Board believes it is appropriate to assess the Company’s viability over
a five year period. This period is also deemed appropriate due to our
Portfolio Manager’s long-term investment horizon and also what it believes
to be investors’ horizons, taking account of the Company’s current
position and the potential impact of the principal risks and uncertainties as
shown in the Strategic Report. The Directors also took into account the
liquidity of the portfolio and the expectation that the Company will pass the
next continuation vote in 2024 when considering the viability of the Company
over the next five years and its ability to meet liabilities as they fall due.

The Directors do not expect there to be any significant change in the
principal risks that have been identified or the adequacy of the mitigating
controls in place, and do not envisage any change in strategy or objectives or
any events that would prevent the Company from continuing to operate over that
period as the Company’s assets are liquid, its commitments are limited and
the Company intends to continue to operate as an investment trust.

Based on this assessment, the Directors have a reasonable expectation that the
Company will be able to continue in operation and meet its liabilities as they
fall due over the next five-year period.

STAKEHOLDER INTERESTS AND BOARD DECISION-MAKING (SECTION 172 OF THE COMPANIES
ACT 2006)

The Directors are required to explain more fully how they have discharged
their duty under s172 of the Companies Act 2006 in promoting the success of
the Company for the benefit of the members as a whole. This includes the
likely consequences of the Directors’ decisions in the long-term and how
they have taken wider stakeholders’ needs into account.

The Directors aim to act fairly between the Company’s stakeholders. The
Board’s approach to shareholder relations is summarised in the Corporate
Governance Report. The Chairman’s Statement provides an explanation of
actions taken by the Directors during the year to achieve the Board’s
long-term aim of ensuring that the Company’s shares trade at a price close
to the NAV per share.

As an externally managed investment trust, the Company has no employees,
customers, operations or premises. Therefore, the Company’s key stakeholders
(other than its shareholders) are considered to be its service providers. The
need to foster business relationships with the service providers and maintain
a reputation for high standards of business conduct are central to the
Directors’ decision-making as the Board of an externally managed investment
trust. The Directors believe that fostering constructive and collaborative
relationships with the Company’s service providers will assist in their
promotion of the success of the Company for the benefit of all shareholders.

The Board engages with representatives from its service providers throughout
the year. Representatives from OrbiMed and Frostrow are in attendance at each
Board meeting. As the Portfolio Manager and the AIFM respectively, the
services they provide are fundamental to the long-term success and smooth
running of the Company. The Chairman’s Statement and the Business Review,
describe relevant decisions taken during the year relating to OrbiMed and
Frostrow. Further details about the matters discussed in Board meetings and
the relationship between OrbiMed and the Board are set out in the Corporate
Governance Report.

Representatives from other service providers are asked to attend Board
meetings when deemed appropriate.

Further details are set out overleaf.

 Who?         Why?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      How?                                                                                                                                                                      
 Stakeholder  The benefits of engagement with the                                                                                                                                                                                                                                                                                                                                                                                                                                                                       How the board, the portfolio manager                                                                                                                                      
  group        company's stakeholders                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    and the AIFM have engaged with the                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         company’s stakeholders                                                                                                                                                   
 Investors    Clear communication of the Company’s strategy and the performance against the Company’s objective can help the share price trade at a narrower discount or a premium to its net asset value per share which benefits shareholders. New shares can be issued to meet demand without net asset value per share dilution to existing shareholders. Increasing the size of the Company can benefit liquidity as well as spread costs. Share buy backs are undertaken at the discretion of the Directors.      The Portfolio Manager and Frostrow, on behalf of the Board, complete a programme of investor relations throughout the year. While such meetings were conducted on a       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        virtual basis during the COVID-19 pandemic, meetings in person are now being held again. In addition, the Chairman has been available to engage with the Company’s larger 
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        shareholders where required. An analysis of the Company’s shareholder register is provided to the Directors at each Board meeting along with marketing reports from       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Frostrow. The Board reviews and considers the marketing plans on a regular basis. Reports from the Company’s broker are submitted to the Board on investor sentiment and  
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        industry issues. Key mechanisms of engagement include:                                                                                                                    

   

 What?                                     Outcomes and actions                                                                                     
 What were the key areas of engagement?    What actions were taken, including main decisions?                                                       
 Key areas of engagement with investors    Frostrow and the Portfolio Manager engage with retail investors through a number of different channels:  

   

 Who?               Why?                                                                                                                                                                      How?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 Stakeholder group  The benefits of engagement with the company's stakeholders                                                                                                                How the board, the portfolio manager  and the AIFM have engaged with the  company’s stakeholders                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
 Portfolio Manager  Engagement with the Company’s Portfolio Manager is necessary to evaluate their performance against the Company’s stated strategy and to understand any risks or           The Board met regularly with the Company’s Portfolio Manager throughout the year. The Board also receives monthly performance and compliance reporting. The Portfolio Manager’s attendance at each Board meeting provides the opportunity for the Portfolio Manager and Board to further reinforce their mutual understanding of what is expected from both parties. The Board encourages the Company’s Portfolio Manager to engage with companies and in doing so expects ESG issues to be an important consideration. The Board receives an update on Frostrow’s engagement activities by way of a dedicated report at Board meetings and at other times during the year as required.                                                                                                
                    opportunities this may present. The Board ensures that the Portfolio Manager’s environmental, social and governance (“ESG”) approach is in line with standards elsewhere                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                    and the Board’s expectations. Engagement also helps ensure that the Portfolio Manager’s fees are closely monitored and remain competitive. Gaining a deeper understanding                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
                    of the portfolio companies and their strategies as well as incorporating consideration of ESG factors into the investment process assists in understanding and mitigating                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
                    risks of an investment as well as identifying future potential opportunities.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 Service Providers  The Company contracts with third parties for other services including: custody, company secretarial, accounting & administration and registrar. The Company ensures that  The Board and Frostrow, acting in its capacity as AIFM, engage regularly with other service providers both in one-to-one meetings and via regular written reporting. This regular interaction provides an environment where topics, issues and business development needs can be dealt with efficiently and collegiately. The Board together with Frostrow have maintained regular contact with the Company’s principal service providers during the pandemic, as well as carrying out a review of the service providers’ business continuity plans and additional cyber security provisions. The review of the performance of the Portfolio Manager and Frostrow is a continuous process carried out by the Board and the Remuneration and Management Engagement Committee with a     
                    the third parties to whom the services have been outsourced complete their roles in line with their service level agreements thereby supporting the Company in its success formal evaluation being undertaken annually.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
                    and ensuring compliance with its obligations. The COVID-19 pandemic has meant that it was vital to make certain there were adequate procedures in place at the Company’s                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                    principal service providers to ensure safety of their employees and the continued high quality service to the Company.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           

   

 What?                                                                                                                                                                                                                                                               Outcomes and actions                                                                                                                                                      
 What were the key areas of engagement?                                                                                                                                                                                                                              What actions were taken, including main decisions?                                                                                                                        
 Key areas of engagement with the Portfolio Manager on an ongoing basis are portfolio composition, performance, outlook and business updates.                                                                                                                                                                                                                                                                                                  
 * The ongoing impact of the pandemic upon their business and how components in the portfolio dealt with the pandemic.                                                                                                                                               - The Board has received regular updates from the Portfolio Manager throughout the pandemic and its impact on investment decision making. In addition, the impact of new  
 * Regular review of the make up of the investment portfolio.                                                                                                                                                                                                        working practices adopted by the Portfolio Manager as a consequence of the pandemic have been reviewed by the Board. - The Portfolio Manager reports on ESG issues at each 
 * The integration of ESG factors into the Portfolio Manager’s investment processes.                                                                                                                                                                                 Board meeting.                                                                                                                                                            
 Key areas of engagement with Service Providers                                                                                                                                                                                                                                                                                                                                                                                                
 * The Directors have frequent engagement with the Company’s other service providers through the annual cycle of reporting. This engagement is completed with the aim of maintaining an effective working relationship and oversight of the services provided.       - No specific action required as the reviews of the Company’s service providers, have been positive and the Directors believe their continued appointment is in the best  
 * The Board sought and received assurances from all of the Company’s service providers that steps had been taken to maintain the ongoing efficiency of their operations while ensuring the safety and well-being of their employees.                                interests of the Company. - The Board agreed to continue to monitor the position closely.                                                                                 
 Key areas of engagement with the broker                                                                                                                                                                                                                                                                                                                                                                                                       
 - The Board is cognisant that the trading of the Company‘s shares at a persistent and significant discount or premium to the prevailing NAV per share is not in the interests of shareholders.                                                                      * Throughout the year the Board closely monitored the Company’s discount/premium to NAV per share and received regular updates from the broker. 80,509 shares were bought 
                                                                                                                                                                                                                                                                     back during the year, and a further 223,842 shares were bought back since the year-end to 25 May 2022. 1,227,500 new shares were issued during the year, no shares issued 
                                                                                                                                                                                                                                                                     following the year-end to 25 May 2022. (Please see the Chairman’s Statement for further information.)                                                                     

INTEGRITY AND BUSINESS ETHICS

The Company is committed to carrying out business in an honest and fair manner
with a zero-tolerance approach to bribery, tax evasion and corruption. As
such, policies and procedures are in place to prevent this. In carrying out
its activities, the Company aims to conduct itself responsibly, ethically and
fairly, including in relation to social and human rights issues.

The Company believes that high standards of ESG make good business sense and
have the potential to protect and enhance investment returns. The Portfolio
Manager’s investment criteria provide that ESG and ethical issues are taken
into account and best practice is encouraged by the Board. The Board’s
expectations are that its principal service providers have appropriate
governance policies in place.

PERFORMANCE AND FUTURE DEVELOPMENTS

A review of the Company’s year, its performance and the outlook for the
Company can be found in the Chairman’s Statement and in the Portfolio
Manager’s Review.

The Company’s overall strategy remains unchanged.

LOOKING TO THE FUTURE

The Board concentrates its attention on the Company’s investment performance
and OrbiMed’s investment approach and on factors that may have an effect on
this approach. Marketing reports are given to the Board at each board meeting
by the AIFM which include how the Company will be promoted and details of
planned communications with existing and potential shareholders. The Board is
regularly updated by the AIFM on wider investment trust industry issues and
discussions are held at each Board meeting concerning the Company’s future
development and strategy.

A review of the Company’s year, its performance since the year-end and the
outlook for the Company can be found in the Chairman’s Statement and in the
Portfolio Manager’s Review. It is expected that the Company’s Strategy
will remain unchanged in the coming year.

ALTERNATIVE PERFORMANCE MEASURES

The Financial Statements set out the required statutory reporting measures of
the Company’s financial performance. In addition, the Board assesses the
Company’s performance against a range of criteria which are viewed as
particularly relevant for investment trusts, which are explained in greater
detail in the Strategic Report, under the heading ‘Key Performance
Indicators’.

By order of the Board

Frostrow Capital LLP

Company Secretary

26 May 2022

BOARD OF DIRECTORS

SIR MARTIN SMITH

Independent Non-Executive Chairman

Joined the Board in 2007 and became Chairman in 2008

Annual remuneration year-end 2022: £53,150pa

Committee Membership

Sir Martin attends the Audit & Risk Committee by invitation and is a member of
the Nominations and Management Engagement & Remuneration Committees.

Shareholding in the Company

11,871 (Beneficial) 2,725 (Trustee)

Skills and Experience

Sir Martin Smith has been involved in the financial services sector for almost
50 years. He was a founder and senior partner of Phoenix Securities, becoming
Chairman of European Investment Banking for Donaldson, Lufkin & Jenrette (DLJ)
following the acquisition of Phoenix by DLJ. He was subsequently a founder of
New Star Asset Management Ltd.

Other Appointments

Sir Martin has a number of other directorships and business interests,
including acting as Chairman Emeritus of GP Bullhound, the technology
investment banking firm. He is also a member of the Advisory Board of Cerno
Capital Partners LLP.

Sir Martin’s pro-bono interests include being a founder of the Orchestra of
the Age of Enlightenment of which he is Life President, and he has served on
the boards of a number of other arts organisations including English National
Opera, the Glyndebourne Arts Trust and the Royal Academy of Music and the
Ashmolean Museum. He is a Trustee of ClientEarth. In 2008 Sir Martin with his
family were founding benefactors of the Smith School of Enterprise and the
Environment at Oxford University.

Standing for re-election: No

SARAH BATES

Independent Non-Executive Director

Joined the Board in 2013

Annual remuneration year-end 2022: £36,007pa

Committee Membership

Sarah is Chair of the Nominations Committee and is the Senior Independent
Director. Sarah is also a member of the Audit & Risk and Management Engagement
& Remuneration Committees.

Shareholding in the Company

7,200

Skills and Experience

Sarah is a past Chair of the Association of Investment Companies and has been
involved in the UK savings and investment industry in different roles for over
35 years.

Sarah is a fellow of CFA UK.

Other Appointments

Sarah is non-executive Chair of Polar Capital Technology Trust plc and a
non-executive Director of Alliance Trust PLC. Sarah is also Chair of The John
Lewis Partnership Pensions Trust of BBC Pension Investments Limited and of the
Universities Superannuation Fund Investment Management Limited. Sarah is a
member of the BBC Pension Scheme Investment Committee and is an Ambassador for
Chapter Zero and a mentor for Chairmen Mentors International.

Standing for re-election: Yes

SVEN BORHO

Non-Executive Director

Joined the Board in 2018

Annual remuneration year-end 2022: Nil

Committee Membership

Sven is not a member of any of the Company’s Committees.

Shareholding in the Company

10,000

Skills and Experience

Sven H. Borho, CFA, is a founder and Managing Partner of OrbiMed. Sven heads
the public equity team and he is the

portfolio manager for OrbiMed’s public equity and hedge funds. He has been a
portfolio manager for the firm’s funds

since 1993 and has played an integral role in the growth of OrbiMed’s asset
management activities.

He started his career in 1991 when he joined OrbiMed’s predecessor firm as a
Senior Analyst covering European

pharmaceutical firms and biotechnology companies worldwide. Sven studied
business administration at

Bayreuth University in Germany and received a M.Sc.(Econs.), Accounting and
Finance, from The London School

of Economics.

Other Appointments

Sven is a Managing Partner of OrbiMed and does not have any other
appointments.

Standing for re-election: Yes

HUMPHREY VAN DER KLUGT, FCA

Independent Non-Executive Director

Joined the Board in 2016

Annual remuneration year-end 2022: £41,133pa

Committee Membership

A Chartered Accountant, Humphrey is Chairman of the Audit & Risk Committee.
Humphrey is also a member of the Management Engagement & Remuneration and the
Nominations Committees.

Shareholding in the Company

3,000

Skills and Experience

Humphrey was formerly Chairman of Fidelity European Values PLC and a Director
of Murray Income Trust PLC, BlackRock Commodities Income Investment Trust plc
and J P Morgan Claverhouse Investment Trust plc. Prior to this Humphrey was a
fund manager and Director of Schroder Investment Management Limited and in a
22 year career was a member of their Group Investment and Asset Allocation
Committees. Prior to joining Schroders, he was with Peat Marwick Mitchell & Co
(now KPMG) where he qualified as a Chartered Accountant in 1979.

Other Appointments

Humphrey is a non-executive Director of Allianz Technology Trust PLC.

Standing for re-election: Yes

DOUG MCCUTCHEON

Independent Non-Executive Director

Joined the Board in 2012

Annual remuneration year-end 2022: £33,573pa

Committee Membership

Doug is Chairman of the Management Engagement & Remuneration Committee. Doug
is also a member of the Audit & Risk and Nominations Committees.

Shareholding in the Company

20,000

Skills and Experience

Doug is the President of Longview Asset Management Ltd., an independent
investment firm that manages the capital of families, charities and
endowments. Prior to this, Doug was an investment banker for 25 years at UBS
and its predecessor firm, S.G. Warburg, where, most recently, he was the head
of Healthcare Investment Banking for Europe, the Middle East, Africa and Asia-
Pacific. Doug is involved in philanthropic organisations with a focus on
healthcare and education. He attended Queen’s University, Canada.

Other Appointments

Doug is a non-executive Director of Labrador Iron Ore Royalty Corporation
listed on the Toronto Stock Exchange.

Standing for re-election: Yes

DR BINA RAWAL

Independent Non-Executive Director

Joined the Board in 2019

Annual remuneration year-end 2021: £33,573pa

Committee Membership

Dr Rawal is a member of the Audit & Risk, Management Engagement & Remuneration
and Nominations Committees.

Shareholding in the Company

1,810

Skills and Experience

Dr Rawal, a physician scientist with 25 years’ experience in Research and
Development, has held senior executive roles in drug development and
scientific evaluation in four global pharmaceutical companies. She has also
worked in senior roles with two medical research funding organisations:
Wellcome Trust and Cancer Research UK.

Other Appointments

Dr Rawal is a non-executive Director of the Central London Community
Healthcare NHS Trust and of Vann Limited. Dr Rawal is also a Trustee on the
Board of the Social Mobility Foundation.

Standing for re-election: Yes

REPORT OF THE DIRECTORS

The Directors present their Annual Report on the affairs of the Company
together with the audited financial statements and the Independent Auditors’
Report for the year ended 31 March 2022.

SIGNIFICANT AGREEMENTS

Details of the services provided under these agreements are included in the
Strategic Report.

Alternative investment fund management agreement

Frostrow is the designated AIFM for the Company on the terms and subject to
the conditions of the alternative investment fund management agreement between
the Company and Frostrow (the “AIFM Agreement”).

The notice period on the AIFM Agreement with Frostrow is 12 months,
termination can be initiated by either party.

Portfolio management agreement

Under the AIFM Agreement Frostrow has delegated the portfolio management
function to OrbiMed, under a portfolio management agreement between it, the
Company and Frostrow (the “Portfolio Management Agreement”).

OrbiMed receives a periodic fee equal to 0.65% p.a. of the Company’s NAV and
a performance fee as set out in the Performance Fee section below. Its
agreement with the Company may be terminated by either party giving notice of
not less than 12 months.

Performance fee

Dependent on the level of long-term outperformance of the Company, OrbiMed is
entitled to a performance fee. The performance fee is calculated by reference
to the amount by which the Company’s NAV performance has outperformed the
Benchmark (see inside front cover for details of the Benchmark).

The fee is calculated quarterly by comparing the cumulative performance of the
Company’s NAV with the cumulative performance of the Benchmark since the
launch of the Company in 1995. The performance fee amounts to 15.0% of any
outperformance over the Benchmark. Provision is made within the daily NAV per
share calculation as required and in accordance with generally accepted
accounting standards.

In order to ensure that only sustained outperformance is rewarded, at each
quarterly calculation date any performance fee payable is based on the lower
of:
1. The cumulative outperformance of the portfolio over the Benchmark as at the
quarter end date; and
2. The cumulative outperformance of the portfolio over the Benchmark as at the
corresponding quarter end date in the previous year
less any cumulative outperformance on which a performance fee has already been
paid.

The effect of this is that outperformance has to be maintained for a twelve
month period before it is paid.

Due to underperformance against the Benchmark during the year, a reversal of
prior period performance fee provisions totalling £18.9 million occurred
(2021: charge of £31.7 million).

As at 31 March 2022 no performance fees were accrued or payable (31 March
2021: £31.7 million). Of the 31 March 2021 accrual £12.9 million was paid
and became payable as at 30 June 2021 and £18.9 million was reversed due to
underperformance, as noted above. The performance fee paid related to
outperformance generated as at 30 June 2020 that was maintained to 30 June
2021.

Depositary agreement

The Company appointed J.P. Morgan Europe Limited (the “Depositary”) as its
Depositary in accordance with the AIFMD on the terms and subject to the
conditions of the Depositary agreement between the Company, Frostrow and the
Depositary (the “Depositary Agreement”).

Under the terms of the Depositary Agreement the Company has agreed to pay the
Depositary a fee calculated at 1.75bp on net assets up to £150 million, 1.50
bps on net assets between £150 million and £300 million, 1.00bps on net
assets between £300 million and £500 million and 0.50bps on net assets above
£500 million.

The Depositary has delegated the custody and safekeeping of the Company’s
assets to J.P. Morgan Securities LLC (the “Custodian and Prime Broker”)
pursuant to a delegation agreement between the Company, Frostrow, the
Depositary and the Custodian and Prime Broker (the “Delegation
Agreement”).

The Delegation Agreement transfers the Depositary’s liability for the loss
of the Company’s financial instruments held in custody by the Custodian and
Prime Broker to the Custodian and Prime Broker in accordance with the AIFMD.
The Company has consented to the transfer and reuse of its assets by the
Custodian and Prime Broker (known as “rehypothecation”) in accordance with
the terms of an institutional account agreement between the Company, the
Custodian and Prime Broker and certain other J.P. Morgan entities (as defined
therein).

Prime brokerage agreement

The Company appointed J.P. Morgan Securities LLC on the terms and subject to
the conditions of the prime brokerage agreement between the Company, Frostrow
and the Depositary (the “Prime Brokerage Agreement”). The Custodian and
Prime Broker receives interest on the drawn overdraft as detailed in note 12.

The Custodian and Prime Broker is a registered broker-dealer and is regulated
by the United States Securities and Exchange Commission.

RESULTS AND DIVIDENDS

The results attributable to shareholders for the year and the transfer to
reserves are shown in the financial statements . Details of the Company’s
dividend record can be found in the Strategic Report.

Substantial interests in share capital

The Company was aware of the following substantial interests in the voting
rights of the Company as at 30 April 2022, the latest practicable date before
publication of the Annual Report:

                                             30 April 2022           31 March 2022        
                                                    % of issued             % of issued   
 Shareholder                             Number of        share  Number of        share   
                                            shares      capital     shares      capital   
 Rathbone Brothers plc                   5,962,688          9.1  5,956,447          9.1   
 Investec Wealth & Investment Limited    4,784,176          7.3  4,763,731          7.3   
 Interactive Investor                    4,066,312          6.2  4,043,547          6.2   
 Hargreaves Lansdown plc                 3,865,715          5.9  3,812,568          5.8   
 Forsyth Barr                            3,370,420          5.2  3,303,660          5.1   
 Charles Stanley & Co Limited            2,900,353          4.5  2,889,422          4.4   
 Brewin Dolphin                          2,421,278          3.7  2,430,556          3.7   
 Quilter Cheviot Investment Management   2,396,904          3.7  2,346,563          3.6   
 Craigs Investment Partners              2,083,678          3.2  2,067,121          3.2   
 Embark Investment Services              2,008,353          3.1  2,031,031          3.1   
 BlackRock                               2,003,967          3.1  2,003,967          3.1   

As at 31 March 2022 the Company had 65,457,246 shares in issue (excluding
80,509 shares held in treasury). As at 30 April 2022 there were 65,233,404
shares in issue (excluding 304,351 shares held in treasury).

DIRECTORS’ & OFFICERS’ LIABILITY INSURANCE COVER

Directors’ & officers’ liability insurance cover was maintained by the
Company during the year ended 31 March 2022 and to the date of this report. It
is intended that this policy will continue for the year ending 31 March 2023
and subsequent years.

DIRECTORS’ INDEMNITIES

During the year under review and to the date of this report, indemnities were
in force between the Company and each of its Directors under which the Company
has agreed to indemnify each Director, to the extent permitted by law, in
respect of certain liabilities incurred as a result of carrying out his or her
role as a Director of the Company. The Directors are also indemnified against
the costs of defending any criminal or civil proceedings or any claim by the
Company or a regulator as they are incurred provided that where the defence is
unsuccessful the Director must repay those defence costs to the Company. The
indemnities are qualifying third party indemnity provisions for the purposes
of the Companies Act 2006.

A copy of each deed of indemnity is available for inspection at the
Company’s registered office during normal business hours and will be
available for inspection at the Annual General Meeting. Please refer to the
Chairman’s Statement for details of this year’s Annual General Meeting
arrangements.

CAPITAL STRUCTURE

The Company’s capital structure is composed solely of ordinary shares.

During the year, a total of 1,227,500 new shares were issued at an average
premium of 0.8% to the prevailing cum income NAV per share. Also, 80,509
shares were repurchased during the year at a discount of 8.4% to the
prevailing cum income NAV per share. These shares are held in treasury.
Following the year-end, to 25 May 2022, the latest practicable date prior to
the publication of this Annual Report, a further 223,842 shares were
repurchased at a discount of 7.0% to the cum income NAV per share. These
shares are also held in treasury. As of 25 May 2022 304,351 shares were held
in treasury (2021: Nil).

Since the year end, to 25 May 2022, no new shares have been issued.

Voting rights in the company’s shares

Details of the voting rights in the Company’s shares at the date of this
Annual Report are given in note 9 to the Notice of Annual General Meeting.

POLITICAL AND CHARITABLE DONATIONS

The Company has not in the past and does not intend in the future to make
political or charitable donations.

MODERN SLAVERY ACT 2015

The Company does not provide goods or services in the normal course of
business, and as a financial investment vehicle does not have customers. The
Directors do not therefore consider that the Company is required to make a
statement under the Modern Slavery Act 2015 in relation to slavery or human
trafficking.

ANTI-BRIBERY AND CORRUPTION POLICY

The Board has adopted a zero tolerance approach to instances of bribery and
corruption. Accordingly it expressly prohibits any Director or associated
persons when acting on behalf of the Company, from accepting, soliciting,
paying, offering or promising to pay or authorise any payment, public or
private in the UK or abroad to secure any improper benefit for themselves or
for the Company.

The Board ensures that its service providers apply the same standards in their
activities for the Company.

A copy of the Company’s Anti Bribery and Corruption Policy can be found on
its website at www.worldwidewh.com. The policy is reviewed regularly by the
Audit Committee.

CRIMINAL FINANCES ACT 2017

The Company has a commitment to zero tolerance towards the criminal
facilitation of tax evasion.

GLOBAL GREENHOUSE GAS EMISSIONS

The Company has no greenhouse gas emissions to report from its operations, nor
does it have responsibility for any other emissions producing sources under
the Companies Act 2006 (Strategic Reports and Directors’ Reports)
Regulations 2013 or the Companies (Directors’ Report) and Limited Liability
Partnerships (Energy and Carbon Report) Regulations 2018, including those
within the Company’s underlying investment portfolio. Consequently, the
Company consumed less than 40,000 kWh of energy during the year in respect of
which the Report of the Directors is prepared and therefore is exempt from the
disclosures required under the Streamlined Energy and Carbon Reporting
criteria.

COMMON REPORTING STANDARD (‘CRS’)

CRS is a global standard for the automatic exchange of information
commissioned by the Organisation for Economic Cooperation and Development and
incorporated into UK law by the International Tax Compliance Regulations 2015.
CRS requires the Company to provide certain additional details to HMRC in
relation to certain shareholders. The reporting obligation began in 2016 and
is an annual requirement. The Registrars, Link Group, have been engaged to
collate such information and file the reports with HMRC on behalf of the
Company.

GOING CONCERN

The financial statements have been prepared on a going concern basis. The
Directors consider this is the appropriate basis as the Company has adequate
resources to continue in operational existence for the foreseeable future,
being taken as 12 months after approval of the financial statements. The
Company’s shareholders are asked every five years to vote for the
continuation of the Company, this will next be put to shareholders at the
Annual General Meeting to be held in 2024. The content of the Company’s
portfolio, trading activity, the Company’s cash balances and revenue
forecasts, and the trends and factors likely to affect the Company’s
performance are reviewed and discussed at each Board meeting. The Board has
considered a detailed assessment of the Company’s ability to meet its
liabilities as they fall due, including stress and liquidity tests which
modelled the effects of substantial falls in markets and significant
reductions in market liquidity, on the Company’s net asset value, its cash
flows and its expenses. Further information is provided in the Audit & Risk
Committee report.

Based on the information available to the Directors at the date of this
report, including the results of these stress tests, the conclusions drawn in
the Viability Statement, the Company’s cash balances, and the liquidity of
the Company’s listed investments, the Directors are satisfied that the
Company has adequate financial resources to continue in operation for at least
the next 12 months and that, accordingly, it is appropriate to continue to
adopt the going concern basis in preparing the financial statements.

ARTICLES OF ASSOCIATION

Amendments of the Company’s Articles of Association requires a special
resolution to be passed by shareholders.

REQUIREMENTS OF THE LISTING RULES

Listing Rule 9.8.4 requires the Company to include certain information in a
single identifiable section of the Annual Report or a cross reference table
indicating where the information is set out. The Directors confirm that there
are no disclosures to be made under Listing Rule 9.8.4.

By order of the Board

Frostrow Capital LLP

Company Secretary

26 May 2022

STATEMENT OF DIRECTORS’ RESPONSIBILITIES

The Directors are responsible for preparing the Annual Report and the
Financial Statements in accordance with applicable law and regulations.
In preparing these financial statements, the Directors are required to:
* select suitable accounting policies and apply them consistently;
* make judgements and estimates that are reasonable and prudent;
* follow applicable UK accounting standards comprising FRS 102; and
* prepare the financial statements on a going concern basis unless it is
inappropriate that the Company will continue in business.
The Directors are responsible for keeping adequate accounting records that are
sufficient to show and explain the Company’s transactions and disclose with
reasonable accuracy at any time the financial position of the Company and
enable them to ensure that the financial statements and the Directors’
Remuneration Report comply with the Companies Act 2006. They are also
responsible for safeguarding the assets of the Company and hence for taking
reasonable steps for the prevention and detection of fraud and other
irregularities.

The Directors are responsible for ensuring that the Report of the Directors
and other information included in the Annual Report is prepared in accordance
with company law in the United Kingdom. They are also responsible for ensuring
that the Annual Report includes information required by the Listing Rules of
the FCA.

The Directors are also responsible for ensuring that the Annual Report and the
Financial Statements are made available on a website. The Annual Report and
the Financial Statements are published on the Company’s website at
www.worldwidewh.com and via Frostrow’s website at www.frostrow.com. The
maintenance and integrity of these websites, so far as it relates to the
Company, is the responsibility of Frostrow. The work carried out by the
Auditors does not involve consideration of the maintenance and integrity of
these websites and, accordingly, the Auditors accept no responsibility for any
changes that have occurred to the financial statements since they were
initially presented on these websites. Visitors to the websites need to be
aware that legislation in the United Kingdom governing the preparation and
dissemination of the financial statements may differ from legislation in their
jurisdiction.

DISCLOSURE OF INFORMATION TO THE AUDITORS

So far as the Directors are aware, there is no relevant information of which
the Auditors are unaware. The Directors have taken all steps they ought to
have taken to make themselves aware of any relevant audit information and to
establish that the Auditors are aware of such information.

RESPONSIBILITY STATEMENT OF THE DIRECTORS IN RESPECT OF THE ANNUAL FINANCIAL
REPORT

The Directors confirm to the best of their knowledge that:
* the Annual Report and the Financial Statements have been prepared in
accordance with applicable accounting standards, give a true and fair view of
the assets, liabilities, financial position and the return for the year ended
31 March 2022;
* the Chairman’s Statement, Strategic Report and the Report of the Directors
include a fair review of the information required by 4.1.8R to 4.1.11R of the
FCA’s Disclosure Guidance and Transparency Rules; and
* the Annual Report and the Financial Statements taken as a whole are fair,
balanced and understandable and provide the information necessary to assess
the Company’s performance, business model and strategy.
On behalf of the Board

Sir Martin Smith

Chairman

26 May 2022

CORPORATE GOVERNANCE

THE BOARD AND COMMITTEES

Responsibility for effective governance lies with the Board. The governance
framework of the Company reflects the fact that as an investment company it
has no employees and outsources portfolio management to OrbiMed and risk
management, company management, company secretarial, administrative and
marketing services to Frostrow Capital LLP.

                                                             THE BOARD  Chairman – Sir Martin Smith  Senior Independent Director – Sarah Bates Four additional non-executive Directors, all considered independent, except for Sven Borho.  Key responsibilities: - to provide leadership and set strategy, values and standards within a framework of prudent effective controls which enable risk to be assessed and managed; - to ensure that a robust corporate governance framework is implemented; and - to challenge constructively and scrutinise performance of all outsourced                                                             
                                                                                                                                                                                                                                                                                                                    activities.                                                                                                                                                                                                                                                                                                                     
    Management Engagement & Remuneration Committee  Chairman Doug McCutcheon All Independent Directors  Key responsibilities: - to review regularly the contracts, the performance and remuneration of the Company’s principal service providers; and - to set the Directors’ Remuneration Policy of the       Audit & Risk Committee  Chairman Humphrey van der Klugt, FCA* All Independent Directors (excluding the    Nominations Committee  Chair Sarah Bates All Independent Directors  Key responsibilities: - to review regularly the Board’s structure and composition; and - to make recommendations for any changes or new appointments.   
                                                                                                                                                  Company.                                                                                                                                                     Chairman, Sir Martin Smith)  Key responsibilities: - to review the Company’s financial reports; - to                                                                                                                                                                                                                                 
                                                                                                                                                                                                                                                                                                               oversee the risk and control environment and financial reporting; and - to review the performance of                                                                                                                                                                                                                                 
                                                                                                                                                                                                                                                                                                                                                 the Company’s external Auditors.                                                                                                                                                                                                                                                                   
* The Directors believe that Humphrey van der Klugt has the necessary recent
and relevant financial experience to Chair the Company’s Audit & Risk
Committee.
Copies of the full terms of reference, which clearly define the
responsibilities of each Committee, can be obtained from the Company Secretary
and can be found at the Company’s website at www.worldwidewh.com. Copies
will also be available for inspection on the day of the Annual General
Meeting.

CORPORATE GOVERNANCE STATEMENT

The Board is committed to maintaining and demonstrating high standards of
corporate governance. The Board has considered the principles and
recommendations of the AIC Code of Corporate Governance published in February
2019 (‘AIC Code’). The AIC Code addresses all the principles set out in
the UK Corporate Governance Code (the ‘UK Code’), as well as setting out
additional provisions on issues that are of specific relevance to the Company.

The Financial Reporting Council has confirmed that by following the AIC Code
boards of investment companies will meet their obligations in relation to the
UK Code and paragraph 9.8.6 of the UK Listing Rules.

The Board considers that reporting in accordance with the principles and
recommendations of the AIC Code (which has been endorsed by the Financial
Reporting Council) provides more relevant and comprehensive information to
shareholders. By reporting against the AIC Code, the Company meets its
obligations under the UK Code (and associated disclosure requirements under
paragraph 9.8.6 of the Listing Rules) and as such does not need to report
further on issues contained in the UK Code which are irrelevant to the Company
as an externally-managed investment company, including the provisions relating
to the role of the chief executive, executive directors’ remuneration and
the internal audit function.

The Company has complied with the principles and recommendations of the AIC
Code.

The AIC Code can be viewed at www.theaic.co.uk and the UK Code can be viewed
on the Financial Reporting Council website at www.frc.org.uk. The Corporate
Governance Report, forms part of the Report of the Directors.

BOARD LEADERSHIP AND PURPOSE

Purpose and strategy

The purpose and strategy of the Company are described in the Strategic Report.

THE BOARD

The Board is responsible for the effective Stewardship of the Company’s
affairs. Strategy issues and all operational matters of a material nature are
considered at its meetings.

The Board consists of six non-executive Directors, each of whom, with the
exception of Sven Borho, is independent of OrbiMed and the Company’s other
service providers. No member of the Board is a Director of another investment
company managed by OrbiMed, nor has any Board member (with the exception of
Sven Borho) been an employee of OrbiMed or any of the Company’s service
providers.

The Board carefully considers the various guidelines for determining the
independence of non-executive Directors, placing particular weight on the view
that independence is evidenced by an individual being independent of mind,
character and judgement. All Directors retire at the AGM each year and, if
appropriate, seek election or re-election. Each Director has signed a letter
of appointment to formalise the terms of their engagement as a non-executive
Director, copies of which are available on request at the office of Frostrow
Capital LLP.

BOARD CULTURE

The Board aims to consider and discuss differences of opinion, unique vantage
points and to exploit fully areas of expertise. The Chairman encourages open
debate to foster a supportive and co-operative approach for all participants.
Strategic decisions are discussed openly and constructively. The Board aims to
be open and transparent with shareholders and other stakeholders and for the
Company to conduct itself responsibly, ethically and fairly in its
relationships with service providers.

The Board has gained assurance on whistleblowing procedures at the Company’s
principal service providers to ensure employees at those companies are
supported in speaking up and raising concerns. No concerns relating to the
Company were raised during the year.

Shareholder relations

The Company has appointed Frostrow to provide marketing and investor relations
services, in the belief that a well marketed investment company is more likely
to grow over time, have a more diverse, stable list of shareholders and its
shares will trade at close to net asset value per share over the long run.
Frostrow actively promotes the Company.

Shareholder communications

The Board, the AIFM and the Portfolio Manager consider maintaining good
communications with shareholders and engaging with larger shareholders through
meetings and presentations a key priority. Shareholders are being informed by
the publication of annual and half-year reports which include financial
statements. These reports are supplemented by the daily release of the net
asset value per share to the London Stock Exchange and the publication of
monthly fact sheets. All this information, including interviews with the
Portfolio Manager, is available on the Company’s website at
www.worldwidewh.com.

The Board supports the principle that the Annual General Meeting be used to
communicate with private investors, in particular. While the COVID-19 pandemic
has necessitated different arrangements for the past two years, shareholders
are usually encouraged to attend the Annual General Meeting, where they are
given the opportunity to question the Chairman, the Board and representatives
of the Portfolio Manager. In addition, the Portfolio Manager makes a
presentation to shareholders covering the investment performance and strategy
of the Company at the Annual General Meeting. Voting at the Annual General
Meeting is conducted on a poll and details of the proxy votes received in
respect of each resolution will be made available on the Company’s website.

The Board monitors the share register of the Company; it also reviews
correspondence from shareholders at each meeting and maintains regular contact
with major shareholders. Shareholders who wish to raise matters with a
Director may do so by writing to them at the registered office of the Company.

Significant holdings and voting rights

Details of the shareholders with substantial interests in the Company’s
shares, the Directors’ authorities to issue and repurchase the Company’s
shares, and the voting rights of the shares are set out in the Directors’
Report.

BOARD MEETINGS

The Board meets formally at least four times each year. A representative of
OrbiMed attends all meetings; representatives from Frostrow Capital LLP are
also in attendance at each Board meeting. The Chairman encourages open debate
to foster a supportive and co-operative approach for all participants.

The Board has agreed a schedule of matters specifically reserved for decision
by the Board. This includes establishing the investment objectives, strategy
and the Benchmark, the permitted types or categories of investments, the
markets in which transactions may be undertaken, the amount or proportion of
the assets that may be invested in any geography or category of investment or
in any one investment, and the Company’s share issuance and share buyback
policies.

The Board, at its regular meetings, undertakes reviews of key investment and
financial data, revenue projections and expenses, analyses of asset
allocation, transactions and performance comparisons, share price and net
asset value performance, marketing and shareholder communication strategies,
the risks associated with pursuing the investment strategy, peer group
information and industry issues.

The Chairman is responsible for ensuring that the Board receives accurate,
timely and clear information. Representatives of OrbiMed and Frostrow Capital
LLP report regularly to the Board on issues affecting the Company.

The Board is responsible for strategy and has established an annual programme
of agenda items under which it reviews the objectives and strategy for the
Company at each meeting.

CONFLICTS OF INTEREST

Company Directors have a statutory obligation to avoid a situation in which
they (and connected persons) have, or can have, a direct or indirect interest
that conflicts, or may possibly conflict, with the interests of the Company.
The Board has in place procedures for managing any actual or potential
conflicts of interest. No conflicts of interest arose during the year under
review.

BOARD FOCUS AND RESPONSIBILITIES

With the day to day management of the Company outsourced to service providers
the Board’s primary focus at each Board meeting is reviewing the investment
performance and associated matters, such as, inter alia, future outlook and
strategy, gearing, asset allocation, investor relations, marketing, and
industry issues.

In line with its primary focus, the Board retains responsibility for all the
key elements of the Company’s strategy and business model, including:
* the Investment Objective, Policy and Benchmark, incorporating the investment
and derivative guidelines and limits, and changes to these;
* the maximum level of gearing and leverage the Company may employ;
* a review of performance against the Company’s KPIs;
* a review of the performance and continuing appointment of service providers;
and
* the maintenance of an effective system of oversight, risk management and
corporate governance.
The Investment Objective, Policy, and Benchmark, including the related limits
and guidelines, are set out in the Strategic Report, along with details of the
gearing and leverage levels allowed.

Details of the principal KPIs and further information on the principal service
providers, their performance and continuing appointment, along with details of
the principal risks, and how they are managed, are set out in the Strategic
Report.

The Corporate Governance Report includes a statement of compliance with
corporate governance codes and best practice, and the Business Review includes
details of the internal control and risk management framework within which the
Board operates.

BOARD COMPOSITION AND SUCCESSION

Succession planning

The Board regularly considers its structure and recognises the need for
progressive refreshment. (Please see the Chairman’s Statement for further
information).

The Board has an approved succession planning policy to ensure that (i) there
is a formal, rigorous and transparent procedure for the appointment of new
Directors; and (ii) the Board is comprised of members who collectively display
the necessary balance of professional skills, experience, length of service
and industry/Company knowledge.

During the year, the Board reviewed the policy on Directors’ tenure and
considered the overall length of service of the Board as a whole.

Policy on the tenure of the chairman and other non-executive directors

The tenure of each non-executive Director, including the Chairman, is not
ordinarily expected to exceed nine years. However, the Board has agreed that
the tenure of the Chairman may be extended for an agreed time provided such an
extension is conducive to the Board’s overall orderly succession. The Board
believes that this more flexible approach to the tenure of the Chairman is
appropriate in the context of the regulatory rules that apply to investment
companies, which ensure that the chair remains independent after appointment,
while being consistent with the need for regular refreshment and diversity.

The Board is, however, continuing the process of refreshing its membership
which will mean that certain Directors will serve for longer than nine years
to ensure that the changes to be implemented are made in an orderly and
structured manner. Further details of this process can be found in the
Chairman’s Statement.

The Board subscribes to the view that long serving Directors should not
necessarily be prevented from forming part of an independent majority. The
Board considers that a Director’s tenure does not necessarily reduce his or
her ability to act independently and will continue to assess each Director’s
independence annually, through a formal performance evaluation.

Appointments to the board

The Nominations Committee considers annually the skills possessed by the Board
and identifies any skill shortages to be filled by new Directors.

The rules governing the appointment and replacement of Directors are set out
in the Company’s articles of association and the aforementioned succession
planning policy. Where the Board appoints a new Director during the year, that
Director will stand for election by shareholders at the next AGM. Subject to
there being no conflict of interest, all Directors are entitled to vote on
candidates for the appointment of new Directors and on the recommendation for
shareholders’ approval for the Directors seeking re-election at the AGM.
When considering new appointments, the Board endeavours to ensure that it has
the capabilities required to be effective and oversee the Company’s
strategic priorities. This will include an appropriate range, balance and
diversity of skills, experience and knowledge. The Company is committed to
ensuring that any vacancies arising are filled by the most qualified
candidates.

Diversity policy

The Company supports the objectives of improving the performance of corporate
boards by encouraging the appointment of the best people from a range of
differing perspectives and backgrounds. The Company recognises the benefits of
diversity (of which gender is one aspect) on the Board and takes this into
account in its Board appointments. The Company is committed to ensuring that
its director search processes actively seek men and women with the right
qualifications so that appointments can be made, on the basis of merit,
against objective criteria from a diverse selection of candidates. The Board
actively considers diversity during director searches.

The Board is continuing with the process of refreshing its membership. Its
intention is for there to continue to be not less than one-third of its
membership as women and for there to be at least one Director from an ethnic
minority background.

MEETING ATTENDANCE

The number of meetings held during the year of the Board and its Committees,
and each Director’s attendance level, is shown below:

                                                                                   Management 
                                                                                 Engagement & 
                                                      Audit & Risk  Nominations  Remuneration 
 Type and number of meetings held in 2021/22   Board     Committee    Committee     Committee 
                                                 (4)           (2)          (1)           (1) 
 Sir Martin Smith^                                 4             –            1             1 
 Sarah Bates                                       4             2            1             1 
 Sven Borho*                                       4             –            –             – 
 Dr David Holbrook+                                1             1            –             – 
 Humphrey van der Klugt                            4             2            1             1 
 Doug McCutcheon                                   4             2            1             1 
 Dr Bina Rawal                                     4             2            1             1 

^         Sir Martin Smith is not a member of the Audit & Risk
Committee

*          Sven Borho does not sit on any of the Company’s
Committees

+         Dr. Holbrook retired from the Board on 8 July 2021

All of the serving Directors attended the Annual General Meeting held on 8
July 2021.

BOARD EVALUATION

During the year the performance of the Board, its committees and individual
Directors (including each Director’s independence) was evaluated through a
formal assessment led by the Senior Independent Director. The performance of
the Chairman was also evaluated by the Senior Independent Director. The review
concluded that the Board was working well. The Board is satisfied that the
structure, mix of skills and operation of the Board continue to be effective
and relevant for the Company.

As an independent external review of the Board was undertaken in 2021 the next
such review will be held in 2024.

The Board pays close attention to the capacity of individual Directors to
carry out their work on behalf of the Company. In recommending individual
Directors to shareholders for re-election, it considered their other Board
positions and their time commitments and is satisfied that each Director has
the capacity to be fully engaged with the Company’s business. The Board has
considered the position of all of the Directors as part of the evaluation
process, and believes that it would be in the Company’s best interests to
propose them for re-election (with the exception of Sir Martin Smith who will
be retiring from the Board at the conclusion of this year’s AGM) at the
forthcoming AGM for the following reasons:

Sarah Bates has been a Director since May 2013. Sarah is a past Chair of the
Association of Investment Companies and has a wealth of experience of the
investment trust sector. She has been involved in the UK savings and
investment industry in different roles for over 35 years. Sarah is the Chair
of the Nominations Committee and the Senior Independent Director.

Sven Borho joined the Board in June 2018. Sven is a founder and Managing
Partner of OrbiMed and heads their public Equity team and is the portfolio
Manager for OrbiMed’s public equity and hedge funds.

Humphrey van der Klugt joined the Board in February 2016. A former fund
manager and Director of Schroder Investment Management Limited, Humphrey has
extensive experience of the investment trust sector. He is a Chartered
Accountant, and Chairman of the Audit Committee.

Doug McCutcheon joined the Board in November 2012. Doug was an investment
banker at S.G Warburg and then UBS for 25 years, most recently as the head of
Healthcare Investment Banking for Europe, the Middle East, Africa and
Asia-Pacific. He is Chairman of the Management Engagement & Remuneration
Committee. Doug will become Chairman of the Company following the retirement
of Sir Martin Smith.

Dr Bina Rawal joined the Board on November 2019. A physician with 25 years’
experience in life sciences research and development, she has held senior
executive roles in drug development and scientific evaluation in four global
pharmaceutical companies. Bina will become chair of the Management Engagement
& Remuneration Committee when Doug McCutcheon becomes Chairman of the Company.

The Chairman is pleased to report that following a formal performance
evaluation, the Directors’ performance continues to be effective and they
continue to demonstrate commitment to the role.

TRAINING AND ADVICE

New appointees to the Board are provided with a full induction programme. The
programme covers the Company’s investment strategy, policies and practices.
The Directors are also given key information on the Company’s regulatory and
statutory requirements as they arise including information on the role of the
Board, matters reserved for its decision, the terms of reference of the Board
Committees, the Company’s corporate governance practices and procedures and
the latest financial information. It is the Chairman’s responsibility to
ensure that the Directors have sufficient knowledge to fulfil their role and
Directors are encouraged to participate in training courses where appropriate.

The Directors have access to the advice and services of a Company Secretary
through its appointed representative which is responsible to the Board for
ensuring that Board procedures are followed and that applicable rules and
regulations are complied with. The Company Secretary is also responsible for
ensuring good information flows between all parties.

There is an agreed procedure for Directors, in the furtherance of their
duties, to take independent professional advice if necessary at the
Company’s expense.

RISK MANAGEMENT AND INTERNAL CONTROLS

The Board has overall responsibility for the Company’s risk management and
internal control systems and for reviewing their effectiveness. The Company
applies the guidance published by the Financial Reporting Council on internal
controls. Internal control systems are designed to manage, rather than
eliminate, the risk of failure to achieve the business objective and can
provide only reasonable and not absolute assurance against material
misstatement or loss. These controls aim to ensure that the assets of the
Company are safeguarded, that proper accounting records are maintained and
that the Company’s financial information is reliable. The Directors have a
robust process for identifying, evaluating and managing the significant risks
faced by the Company, which are recorded in a risk matrix. The Audit
Committee, on behalf of the Board, considers each risk as well as reviewing
the mitigating controls in place. Each risk is rated for its “likelihood”
and “impact” and the resultant numerical rating determines its ranking
into ‘Principal/Key’, ‘Significant’ or ’Minor’. This process was
in operation during the year and continues in place up to the date of this
report. The process also involves the Audit Committee receiving and examining
regular reports from the Company’s principal service providers. The Board
then receives a detailed report from the Audit Committee on its findings. The
Directors have not identified any significant failures or weaknesses in
respect of the Company’s internal control systems.

BENEFICIAL OWNERS OF SHARES – INFORMATION RIGHTS

Beneficial owners of shares who have been nominated by the registered holder
of those shares to receive information rights under section 146 of the
Companies Act 2006 are required to direct all communications to the registered
holder of their shares rather than to the Company’s registrar, Link Group,
or to the Company directly.

The Company has adopted a nominee share code which is set out on the following
page.

The annual and half-year financial reports, and a monthly fact sheet are
available to all shareholders. The Board, with the advice of Frostrow, reviews
the format of the annual and half-year financial reports so as to ensure they
are useful to all shareholders and others taking an interest in the Company.
In accordance with best practice, the annual report, including the Notice of
the Annual General Meeting, is sent to shareholders at least 20 working days
before the meeting. Separate resolutions are proposed for substantive issues.

ANNUAL GENERAL MEETING

The following information to be considered at the forthcoming annual general
meeting is important and requires your immediate attention.

If you are in any doubt about the action you should take, you should seek
advice from your stock broker, bank manager, solicitor, accountant or other
financial adviser authorised under the Financial Services and Markets Act 2000
(as amended). If you have sold or transferred all of your ordinary shares in
the Company, you should pass this document, together with any other
accompanying documents, including the form of proxy, at once to the purchaser
or transferee, or to the stock broker, bank or other agent through whom the
sale or transfer was effected, for onward transmission to the purchaser or
transferee.

The Company’s Annual General Meeting will be held at etc.Venues, 1-3 Bonhill
Street, London EC2A 4BY on Wednesday, 6 July 2022 from 12.30 p.m. Please refer
to the Chairman’s Statement for details of this year’s arrangements.

Resolutions relating to the following items of special business will be
proposed at the forthcoming Annual General Meeting.

 Resolution 11  Authority to allot shares                                                                                       
 Resolution 12  Authority to disapply pre-emption rights                                                                        
 Resolution 13  Authority to sell shares held in Treasury on a non pre-emptive basis                                            
 Resolution 14  Authority to buy-back shares                                                                                    
 Resolution 15  Authority to hold General Meetings (other than the Annual General Meeting) on at least 14 clear days’ notice    

The full text of the resolutions can be found in the Notice of Annual General
Meeting.

EXERCISE OF VOTING POWERS

The Board and the AIFM have delegated authority to OrbiMed to vote the shares
owned by the Company. The Board has instructed that OrbiMed submit votes for
such shares wherever possible. This accords with current best practice whilst
maintaining a primary focus on financial returns. OrbiMed may refer to the
Board on any matters of a contentious nature. The Board has reviewed
OrbiMed’s Voting Guidelines and is satisfied with their approach.

The Company does not retain voting rights on any shares that are held as
collateral in connection with the overdraft facility provided by J.P. Morgan
Securities LLC.

NOMINEE SHARE CODE

Where shares are held in a nominee company name, the Company undertakes:
* to provide the nominee company with multiple copies of shareholder
communications, so long as an indication of quantities has been provided in
advance; and
* to allow investors holding shares through a nominee company to attend
general meetings, provided the correct authority from the nominee company is
available.
Nominee companies are encouraged to provide the necessary authority to
underlying shareholders to attend the Company’s general meetings.

By order of the Board

Frostrow Capital LLP

Company Secretary

26 May 2022

AUDIT & RISK COMMITTEE REPORT

INTRODUCTION FROM THE CHAIRMAN

I am pleased to present my formal report to shareholders as Chairman of the
Audit & Risk Committee, for the year ended 31 March 2022. During the year
under review, a decision was made to rename the Audit Committee as the Audit &
Risk Committee. The change was made because the Committee carries out a full
and thorough review of the risks associated with the Company and the Board
agreed that this should better be reflected in the name of the Committee.

COMPOSITION AND MEETINGS

The Committee comprises those Directors considered to be independent by the
Board. The Chairman of the Board is not a member of the Committee but attends
meetings by invitation. The Committee met twice during the year. The Board has
taken note of the requirements that the Committee as a whole should have
competence relevant to the sector in which the Company operates and that at
least one member of the Committee should have recent and relevant financial
experience. The Committee is satisfied that it is properly constituted in both
respects. I was appointed Chairman of the Committee in 2016 and am a Fellow of
the Institute of Chartered Accountants in England and Wales, I am also the
Chairman of the Audit & Risk Committee of one other public company; the other
Committee members have a combination of financial, investment and other
relevant experience gained throughout their careers.

RESPONSIBILITIES

The Committee’s main responsibilities during the year were:
1. To review the Company’s Half-Year and Annual Report. In particular, the
Committee considered and advised the Board on whether the Annual Report and
the Financial Statements, taken as a whole, is fair, balanced and
understandable, allowing shareholders to more easily assess the Company’s
strategy, investment policy, business model and financial performance.
2. To review the risk management and internal control processes of the Company
and its key service providers. Further details of the Committee’s review are
included in the Principal Risks section..
3. To develop and implement a policy for the engagement of the external
Auditors and agreeing the scope of its work and its remuneration. Also, to be
responsible for the selection process of the external Auditors (including the
leadership of an audit tender process) and to have primary responsibility for
the Company’s relationship with the external Auditors.
4. To review the effectiveness of the external audit and the process.
5. To review the independence and objectivity of the external Auditors.
6. To consider any non-audit work to be carried out by the Auditors. The
Committee reviews the need for non-audit services to be provided by the
Auditors and authorises such on a case by case basis, having consideration to
the cost effectiveness of the services and the independence and objectivity of
the Auditors.
7. To consider the need for an internal audit function. Since the Company
delegates its day-to-day operations to third parties and has no employees, the
Committee has determined there is no requirement for such a function.
8. To assess the going concern and viability of the Company, including the
assumptions used.
9. To report its findings to the Board.
A comprehensive description of the Committee’s role, its duties and
responsibilities, can be found in its terms of reference which are available
for review on the Company’s website at www.worldwidewh.com.

SIGNIFICANT ISSUES CONSIDERED BY THE AUDIT & RISK COMMITTEE DURING THE YEAR

Financial Statements

The production of the Company’s Annual Report (including the audit by the
Company’s external Auditors) is a thorough process involving input from a
number of different areas. In order to be able to confirm that the Annual
Report is fair, balanced and understandable, the Board has requested that the
Committee advise on whether it considers these criteria have been satisfied.
As part of this process the Committee has considered the following:
* the procedures followed in the production of the Annual Report, including
the processes in place to assure the accuracy of the factual content;
* the extensive levels of review that were undertaken in the production
process, by the Company’s AIFM and the Committee; and
* the internal control environment as operated by the Portfolio Manager, AIFM
and other service providers.
As a result of the work undertaken by the Committee, it has confirmed to the
Board that the Annual Report and the Financial Statements for the year ended
31 March 2022, taken as a whole, is fair, balanced and understandable and
provides the information necessary for shareholders to assess the Company’s
financial position, performance, business model and strategy.

Audit Regulation

While the Committee has not had to consider any new audit regulations in the
past year, there have been a number of initiatives to consider including with
regard to the roles, responsibilities and accountability of Directors, Audit
Committees, Auditors and the Regulator itself, with reports published by
Kingman, Brydon and the CMA. The Business Enterprise, Industry and Skills
(BEIS) Select Committee has also published a report containing its views on
the future of audit. The Committee will continue to keep a close review of
developments.

In addition to this, the Committee also reviews the outcomes of the FRC’s
annual Audit Quality Reviews and discusses the findings with our Auditors.

SIGNIFICANT REPORTING MATTERS

Overall accuracy of the annual report

The Committee dealt with this matter by considering the draft Annual Report, a
letter from Frostrow in support of the letter of representation made by the
Board to the Auditors and the Auditors’ Report to the Committee.

Valuation and ownership of the company’s investments and derivatives

The Committee dealt with this matter by:
* ensuring that all investment holdings and cash/ deposit balances had been
agreed to an independent confirmation from the Custodian and Prime Broker or
relevant counterparty. In addition, receiving and reviewing details of the
internal control procedures in place at the Portfolio Manager, the AIFM and
the Custodian and Prime Broker and also regular reports from both the
Custodian and Prime Broker and also the Depositary (whose role it is to ensure
that the Company’s assets are safeguarded and to verify their valuation);
* reconfirming its understanding of the processes in place to record
investment transactions and income, and to value both the quoted and unquoted
holdings in the portfolio;
* reviewing and amending, where necessary, the Company’s register of key
risks in light of changes to the portfolio and the investment environment;
* gaining an overall understanding of the performance of the portfolio both in
capital and revenue terms through comparison to the Benchmark; and
* conducting a review of how the Company’s derivative positions were
monitored.
Valuation of unquoted investments

The Company has the ability to make unquoted investments within its investment
portfolio, up to a limit of 10% of the portfolio at the time of acquisition.
Both the Company’s Directors and the AIFM need to ensure that an appropriate
value is placed on such investments within the Company’s net asset value.
The Committee has worked with the Company’s Portfolio Manager and the AIFM
to establish clear guidelines for the valuation of unquoted investments,
including the use of valuations produced by independent external valuers,
where appropriate.

OTHER REPORTING MATTERS

COVID-19

The Committee continued to pay particular attention to the effects and
potential effects on the Company of the COVID-19 pandemic. The long-term
effect of the pandemic on the global economy is becoming clearer and the
Committee will continue to monitor the impact of COVID-19, which is also
captured in the Company’s risk register.

In order to mitigate the business risks caused by the pandemic, the Committee
continues to review the operational resilience of its various service
providers, who have continued to demonstrate their ability to provide services
to the expected level, whilst doing so remotely.

Calculation of AIFM, portfolio management and performance fees

The AIFM, Portfolio Management and Performance fees are calculated in
accordance with the AIFM and Portfolio Management Agreements. The Auditors
perform agreed upon procedures over any performance fee prior to payment. The
Auditors also recalculate the AIFM and Portfolio Management fee as part of the
audit.

Investment trust status

The Committee approached and dealt with ensuring compliance with Section 1158
of the Corporation Tax Act 2010, by seeking confirmation from Frostrow that
the Company continues to meet the eligibility conditions on a monthly basis.

Investment performance

The Committee gained an overall understanding of the performance of the
investment portfolio both in capital and revenue terms through ongoing
discussions and analysis with the Company’s Portfolio Manager and also with
comparison to suitable key performance indicators.

Accounting policies

During the year the Committee ensured that the accounting policies were
applied consistently throughout the year. In light of there being no unusual
transactions during the year or other possible reasons, the Committee agreed
that there was no reason to change the policies.

Going concern

Having reviewed the Company’s financial position and liabilities, the
Committee is satisfied that it is appropriate for the Board to prepare the
financial statements on the going concern basis. The Committee’s review of
the Company’s financial position included consideration of the cash and cash
equivalent position of the Company; the diversification of the portfolio; and
the analysis of portfolio liquidity, which estimated a liquidation of c.92% of
the portfolio within 10 trading days (based on current market volumes).

Viability statement

The Committee also considered the longer-term viability of the Company in
connection with the Board’s statement in the Strategic Report. The Committee
reviewed the Company’s financial position (including its cash flows and
liquidity position), the principal risks and uncertainties, the expectation
that the Company will pass the next continuation vote in 2024, and the results
of stress tests and scenarios which considered the impact of severe stock
market volatility on shareholders’ funds. This included modelling
substantial market falls, and significantly reduced market liquidity. The
scenarios assumed that there would be no recovery in asset prices and that
listed portfolio companies which have cut or cancelled any dividends due since
the coronavirus outbreak would not reinstate them.

The results demonstrated the impact on the Company’s NAV, its expenses, its
cash flows and its ability to meet its liabilities. In even the most stressed
scenario, the Company was shown to have sufficient cash, or to be able to
liquidate a sufficient portion of its listed holdings, in order to be able to
meet its liabilities as they fall due. Based on the information available to
the Directors at the time, the Committee therefore concluded it was reasonable
for the Board to expect that the Company will be able to continue in operation
and meet its liabilities as they fall due over the next five financial years.
The Committee expects that the Company will continue to exist for the
foreseeable future and at least for the period of the assessment.

INTERNAL CONTROLS AND RISK MANAGEMENT

The Board is responsible for the risk assessment and review of internal
controls of the Company, undertaken in the context of the overall investment
objective.

The review covers the key business, operational, compliance and financial
risks facing the Company. In arriving at its judgement of what risks the
Company faces, the Board has considered the Company’s operations in the
light of the following factors:
* the nature of the Company, with all management functions outsourced to third
party service providers;
* the nature and extent of risks which it regards as acceptable for the
Company to bear within its overall investment objective;
* the threat of such risks becoming a reality; and
* the Company’s ability to reduce the incidence and impact of risk on its
performance.
Against this background, a risk matrix has been developed which covers all key
risks the Company faces, the likelihood of their occurrence and their
potential impact, how these risks are monitored and mitigating controls in
place. The Board has delegated to the Committee the responsibility for the
review and maintenance of the risk matrix and it reviews, in detail, the risk
matrix each time it meets, bearing in mind any changes to the Company, its
environment or service providers since the last review. Any significant
changes to the risk matrix are discussed with the whole Board.

Principal service providers

In addition to reviewing the systems of internal control in place at the
Company’s principal service providers, the Committee also reviewed the cyber
security strategies adopted by them.

Half year report and financial statements

The Committee reviewed the Half Year Report and Financial Statements, which
are not audited or reviewed by the external Auditors, to ensure that the
accounting policies used in the Annual Financial Statements were also used at
the half-year stage and that they portrayed a fair balanced and understandable
picture of the period in question.

INTERNAL AUDIT

The Committee considered whether there was a need for the Company to have an
internal audit function. As the Company delegates its day-to-day operations to
third parties and has no employees, the Committee concluded that there was no
such need.

EXTERNAL AUDITORS

Meetings

This year the nature and scope of the audit together with
PricewaterhouseCoopers LLP’s audit plan were considered by the Committee on
3 November 2021. I, as Chairman of the Committee, had a separate meeting with
them specifically to discuss the audit and any issues that arose. The
Committee then met PricewaterhouseCoopers LLP on 23 May 2022 via video
conference to review formally the outcome of the audit and to discuss the
limited issues that arose. The Committee also discussed the presentation of
the Annual Report with the Auditors and sought their perspective.

Independence and effectiveness

In order to fulfil the Committee’s responsibility regarding the independence
of the Auditors, the Committee reviewed:
* the senior audit personnel in the audit plan for the year,
* the Auditors’ arrangements concerning any conflicts of interest,
* the extent of any non-audit services, and
* the statement by the Auditors that they remain independent within the
meaning of the regulations and their professional standards.
REMUNERATION

The Committee approved a fee of £46,725 for the audit for the year ended 31
March 2022 (2021: £44,500). While this represents an increase on the previous
year’s fee, the Committee believes that the fee is in line with general
audit fees payable for the quoted investment trust sector and is reflective of
the level of work required to audit a listed company.

Non-audit services policy

The Company operates on the basis whereby the provision of all non-audit
services by the Auditors has to be pre-approved by the Committee. Such
services are only permissible where no conflicts of interest arise, the
service is not expressly prohibited by audit legislation, where the
independence of the Auditors is not likely to be impinged by undertaking the
work and the quality and the objectivity of both the non-audit work and audit
work will not be compromised. The Committee will monitor the need for
non-audit work to be performed by the Auditors, if any, in accordance with the
Company’s non-audit services policy. A copy of the Company’s non-audit
services policy can be found on the Company’s website at www.worldwidewh.com

Non-audit fees of £5,000 (2021: nil) were payable to the Auditors during the
year for agreed upon procedures in relation to their review of the
Company’s performance fee payment.

The Committee has considered the extent and nature of non-audit work performed
by the Auditors and is satisfied that this did not impinge on their
independence and is a cost effective way for the Company to operate.

Appointment and tenure

PricewaterhouseCoopers LLP were appointed on 14 July 2014 following a formal
tender process and this appointment has been renewed at each subsequent AGM.

As a public company listed on the London Stock Exchange, the Company is
subject to mandatory auditor rotation requirements. The Company will put the
external audit out to tender at least every 10 years, and change auditor at
least every 20 years. The Committee will, however, continue to consider
annually the need to go to tender for audit quality, remuneration or
independence reasons. Unless any such grounds for change arise in the interim,
it is expected that the next audit tender will take place in the autumn of
2023, in order that the successful candidate’s appointment or re-appointment
can be approved by shareholders at the AGM to be held in 2024. A range of
audit firms will be considered not just those who are considered to be part of
the “Big Four” group of audit firms. The Committee will be mindful of any
potential conflicts of interest. Any firms providing services to the Company
within a two-year period of the date of the audit tender will be unable to
participate.

The Committee has adopted formal audit tender guidelines to govern the audit
tender process.

Auditors’ reappointment

PricewaterhouseCoopers LLP have indicated their willingness to continue to act
as Auditors to the Company for the forthcoming year and a resolution for their
re-appointment will be proposed at the AGM.

The Committee reviews the scope and effectiveness of the audit process,
including agreeing the Auditors’ assessment of materiality and monitors the
Auditors’ independence and objectivity. It conducted a review of the
performance of the Auditors during the year and concluded that performance was
satisfactory and there were no grounds for change.

PERFORMANCE EVALUATION

The Committee’s performance over the past year was reviewed and discussed as
part of the annual Board evaluation. The evaluation considered the composition
of the Committee and the efficacy of Committee meetings, as well as assessing
the Committee’s role in monitoring and overseeing the Company’s financial
reporting and accounting, risk management and internal controls, compliance
with corporate governance regulations and also the assessment of the external
audit.

This year, an internal evaluation was completed and I am pleased to confirm
that the evaluation result was positive and no matters of concern or
requirements for change were highlighted.

AUDIT & RISK COMMITTEE CONFIRMATION

The Audit & Risk Committee confirms that it has carried out a review of the
effectiveness of the system of internal financial control and risk management
during the year, as set out above and that:
1. An ongoing procedure for identifying, evaluating and managing significant
risks faced by the Company was in place for the year under review and up to 27
May 2022. This procedure is regularly reviewed by the Board; and
2. It is responsible (on behalf of the Board) for the Company’s system of
internal controls and for reviewing its effectiveness and that it is designed
to manage the risk of failure to achieve business objectives. This can only
provide reasonable not absolute assurance against material misstatement or
loss.
Humphrey van der Klugt, FCA

Chairman of the Audit & Risk Committee

26 May 2022

DIRECTORS’ REMUNERATION REPORT

INTRODUCTION FROM THE CHAIR

This report has been prepared in accordance with Schedule 8 of the Large and
Medium-sized Companies and Groups (Accounts and Reports) (Amendment)
Regulation 2013, the requirements of Section 421 of the Companies Act 2006 and
the Enterprise and Regulatory Reform Act 2013. A non-binding Ordinary
Resolution for the approval of this report will be put to shareholders at the
Company’s forthcoming AGM. The law requires the Company’s Auditors to
audit certain of the disclosures provided in this report. Where disclosures
have been audited, they are indicated as such and the Auditors’ audit
opinion is included in its report to shareholders.

The Management Engagement & Remuneration Committee considers the framework for
the remuneration of the Directors on an annual basis. It reviews the ongoing
appropriateness of the Directors’ Remuneration Policy and the individual
remuneration of Directors by reference to the activities and particular
complexities of the Company and comparison with other companies of a similar
structure and size. This is in-line with the AIC Code.

A non-binding Ordinary Resolution proposing the adoption of the Directors’
Remuneration Report was put to shareholders at the Annual General Meeting of
the Company held on 8 July 2021, and was passed with 99.9% of the votes cast
by shareholders voting in favour of the Resolution.

As noted in the Strategic Report, all of the Directors are non-executive and
therefore there is no Chief Executive Officer. The Company does not have any
employees. There is therefore no Chief Executive Officer or employee
information to disclose.

Directors’ remuneration policy

The Directors’ Remuneration Policy provides that fees payable to the
Directors should reflect the time spent by the Board on the Company’s
affairs and the responsibilities borne by the Directors and should be
sufficient to enable candidates of high calibre to be recruited. Directors are
remunerated in the form of fees payable monthly in arrears, paid to the
Director personally or to a specified third party. There are no long-term
incentive schemes, share option schemes, pension arrangements, bonuses, or
other benefits in place and fees are not specifically related to the
Directors’ performance, either individually or collectively.

The remuneration for the non-executive Directors is determined within the
limits set out in the Company’s Articles of Association. The present limit
is £350,000 in aggregate per annum. The amount paid in aggregate to the
Directors in 2022 is set out in the table on the following page.

A binding resolution to approve the Directors’ Remuneration Policy was put
to shareholders at the Annual General Meeting held in 2020, and was passed
with 99.8% of shareholders voting in favour of the Resolution. The
aforementioned Directors’ Remuneration Policy provisions apply until the
next time that they are put to shareholders for the renewal of that approval,
which must be at intervals of not more than three years, or if the
Directors’ Remuneration Policy is varied. As approval of this policy was
last granted by shareholders at the Annual General Meeting held in July 2020,
shareholder approval will again be sought at the Annual General Meeting to be
held in 2023.

Directors’ appointment

None of the Directors has a service contract. The terms of their appointment
provide that Directors shall retire and be subject to election at the first
Annual General Meeting after their appointment and to re-election annually
thereafter. The terms also provide that a Director may be removed without
notice and that compensation will not be due on leaving office.

Directors’ fees

Following a review by the Management Engagement & Remuneration Committee it
was agreed that the Directors’ fees would not be increased with effect from
1 April 2022.

All of the Directors, as at the date of this report, served throughout the
year. The table overleaf excludes any employer’s national insurance
contributions, if applicable.

The Directors are entitled to be reimbursed for reasonable expenses incurred
by them in connection with the performance of their duties and attendance at
Board and General Meetings.

                                  Year Ending                  Year Ended         
                                31 March 2023               31 March 2022         
                                    Fee Level       2023 %      Fee Level  2022 % 
 Director                         (per annum)       Change    (per annum)  Change 
 Chairman                             £53,150     –               £53,150     4.0 
 Audit & Risk Committee Chair         £41,133            –        £41,133     4.0 
 Senior Independent Director          £35,389            –        £35,389     4.0 
 Director                             £33,573            –        £33,573     4.0 
                                                                                  

Sums paid to third parties

None of the fees referred to in the below table were paid to any third party
in respect of the services provided by any of the Directors.

Directors’ emoluments for the year (audited)

                                                         Taxable                           Taxable             
                                   Date of  Fixed fees  Expenses              Fixed fees  Expenses             
                               Appointment         (£)      (£)†   Total (£)         (£)      (£)†   Total (£) 
                              to the Board        2022      2022        2022        2021      2021        2021 
 Sir Martin Smith          8 November 2007      53,150       865      54,015      51,106         –      51,106 
 Humphrey Van Der Klugt   15 February 2016      41,133         –      41,133      39,551         –      39,551 
 Sarah Bates#                  22 May 2013      35,389         –      35,389      32,282         –      32,282 
 Dr David Holbrook^        8 November 2007       9,833         –       9,833      34,622         –      34,622 
 Doug McCutcheon           7 November 2012      33,573         –      33,573      32,282         –      32,282 
 Sven Borho*                   7 June 2018           –         –           –           –         –           – 
 Dr Bina Rawal             1 November 2019      33,573         –      33,573      32,282         –      32,282 
 Total                                         206,651       865     207,516     222,125         –     222,125 
* Taxable expenses primarily comprise travel and associated expenses incurred
by the Directors in attending Board and Committee meetings in London. These
are reimbursed by the Company and, under HMRC Rules, are subject to tax and
National Insurance and therefore are treated as a benefit in kind within this
table.
*          Mr Borho has waived his Director’s fee.

^          Dr Holbrook retired from the Board on 8 July 2021.

#         Sarah Bates was appointed as the Senior Independent Director
with effect from 8 July 2021.

In certain circumstances, under HMRC rules travel and other out of pocket
expenses reimbursed to the Directors may be considered as taxable benefits.
Where expenses are classed as taxable under HMRC guidance, they are shown in
the taxable expenses column of the Directors’ remuneration table along with
the associated tax liability.

No communications have been received from shareholders regarding Directors’
remuneration.

Directors’ interests in the company’s shares (audited)

                                        Ordinary 
                              Shares of 25p each 
                            31 March    31 March 
                                2022        2021 
 Sir Martin Smith             11,871      11,871 
 – Trustee                     2,725       2,725 
 Sarah Bates                   7,200       7,200 
 Dr David Holbrook*                –       1,094 
 Sven Borho                   10,000      10,000 
 Humphrey van der Klugt        3,000       3,000 
 Doug McCutcheon              20,000      15,000 
 Dr Bina Rawal                 1,810       1,000 
                              56,606      51,890 

*          Dr Holbrook retired from the Board on 8 July 2021.

Share price total return

The chart below illustrates the total shareholder return for a holding in the
Company’s shares as compared to the Benchmark, which the Board has adopted
as the key measure of the Company’s performance.

TOTAL SHAREHOLDER RETURN FOR THE TEN YEARS TO 31 MARCH 2022

Relative cost of directors’ remuneration

The bar chart below shows the comparative cost of Directors’ fees compared
with the level of dividend distribution and ongoing charges for 2021 and 2022.

Annual statement

On behalf of the Board, I confirm that the Directors’ Remuneration Policy,
and Directors’ Remuneration Report summarise, as applicable, for the year to
31 March 2022:
1. the major decisions on Directors’ remuneration;
2. any substantial changes relating to Directors’ remuneration made during
the year; and
3. the context in which the changes occurred and decisions have been taken.
Doug McCutcheon

Chair of the Management Engagement & Remuneration Committee

26 May 2022

INDEPENDENT AUDITORS’ REPORT TO THE MEMBERS OF WORLDWIDE HEALTHCARE TRUST
PLC

REPORT ON THE AUDIT OF THE FINANCIAL STATEMENTS

OPINION

In our opinion, Worldwide Healthcare Trust PLC’s financial statements:
* give a true and fair view of the state of the Company’s affairs as at 31
March 2022 and of its loss and cash flows for the year then ended;
* have been properly prepared in accordance with United Kingdom Generally
Accepted Accounting Practice (United Kingdom Accounting Standards, comprising
FRS 102 “The Financial Reporting Standard applicable in the UK and Republic
of Ireland”, and applicable law); and
* have been prepared in accordance with the requirements of the Companies Act
2006.
We have audited the financial statements, included within the Annual Report,
which comprise: the Statement of Financial Position as at 31 March 2022; the
Income Statement, the Statement of Changes in Equity and the Statement of Cash
Flows for the year then ended; and the notes to the financial statements,
which include a description of the significant accounting policies.

Our opinion is consistent with our reporting to the Audit & Risk Committee.

BASIS FOR OPINION

We conducted our audit in accordance with International Standards on Auditing
(UK) (“ISAs (UK)”) and applicable law. Our responsibilities under ISAs
(UK) are further described in the Auditors’ responsibilities for the audit
of the financial statements section of our report. We believe that the audit
evidence we have obtained is sufficient and appropriate to provide a basis for
our opinion.

Independence

We remained independent of the Company in accordance with the ethical
requirements that are relevant to our audit of the financial statements in the
UK, which includes the FRC’s Ethical Standard, as applicable to listed
public interest entities, and we have fulfilled our other ethical
responsibilities in accordance with these requirements.

To the best of our knowledge and belief, we declare that non-audit services
prohibited by the FRC’s Ethical Standard were not provided.

Other than those disclosed in the Audit & Risk Committee Report, we have
provided no non-audit services to the Company in the period under audit.

OUR AUDIT APPROACH

Overview

Audit scope
* The Company is a standalone Investment Trust Company and engages Frostrow
Capital LLP (the “AIFM”) to manage its assets.
* We conducted our audit of the financial statements using information from
the AIFM and J.P. Morgan Europe Limited with whom the AIFM have engaged to
provide certain administrative functions.
* We tailored the scope of our audit taking into account the types of
investments within the Company, the involvement of the third parties referred
to above, the accounting processes and controls, and the industry in which the
Company operates.
* We obtained an understanding of the control environment in place at the AIFM
and adopted a fully substantive testing approach using reports obtained from
the AIFM and service providers.
Key audit matters
* Income from Investments
* Valuation and existence of investments
Materiality
* Overall materiality: £22,682,000 (2021: £23,600,000) based on
approximately 1% of net assets.
* Performance materiality: £17,011,000 (2021: £17,700,000).
The scope of our audit

As part of designing our audit, we determined materiality and assessed the
risks of material misstatement in the financial statements.

In planning our audit, we made enquiries of management to understand the
extent of the potential impact of climate change risk on the Company’s
financial statements.

The Directors and the AIFM concluded that there was no material impact on the
financial statements. Our

evaluation of this included assessing how the Directors had incorporated
climate risk factors into the key area of judgement and estimation in the
financial statements, being in relation to the process of valuation of
unlisted investments. We also considered the consistency of the climate change
disclosures included in the Strategic Report with the financial statements and
our knowledge from our audit.

Key audit matters

Key audit matters are those matters that, in the auditors’ professional
judgement, were of most significance in the audit of the financial statements
of the current period and include the most significant assessed risks of
material misstatement (whether or not due to fraud) identified by the
auditors, including those which had the greatest effect on: the overall audit
strategy; the allocation of resources in the audit; and directing the efforts
of the engagement team. These matters, and any comments we make on the results
of our procedures thereon, were addressed in the context of our audit of the
financial statements as a whole, and in forming our opinion thereon, and we do
not provide a separate opinion on these matters.

This is not a complete list of all risks identified by our audit.

Consideration of the impacts of COVID-19 and calculation of the performance
fee accrual, which were key audit matters last year, are no longer included
because of the reduced uncertainty of the impact of COVID-19 and the absence
of a performance fee in the current year. Otherwise, the key audit matters
below are consistent with last year.

 KEY AUDIT MATTER                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                HOW OUR AUDIT ADDRESSED THE KEY AUDIT MATTER                                                                                                                              
 Income from investments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
 Refer to the Audit & Risk Committee Report), the Principal Accounting Policies and the Notes to the Financial Statements). ISAs (UK) presume there is a risk of fraud in income recognition because of the pressure management may feel to achieve a certain objective. In this instance, we consider that ‘income’ refers to all the Company’s income streams, both revenue and capital (including gains and losses on investments). As the Company has a capital objective, there might be an incentive to overstate income in that category if capital is particularly underperforming. As such, we focussed this risk on the existence/occurrence of gains/losses on investments and completeness of dividend income recognition and its presentation in the Income Statement as set out in the requirements of The Association of Investment Companies’ Statement of Recommended Practice (the “AIC SORP”).                We assessed the accounting policy for income recognition for compliance with accounting standards and the AIC SORP and performed testing to confirm that income had been  
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 accounted for in accordance with this stated accounting policy. We found that the accounting policies implemented were in accordance with accounting standards and the AIC 
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 SORP, and that income has been accounted for in accordance with the stated accounting policy. We understood and assessed the design and implementation of key controls    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 surrounding income recognition. The gains/losses on investments held at fair value comprise realised and unrealised gains/losses. For unrealised gains and losses, we     
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 sample tested the valuation of the portfolio at the year-end (see below), together with testing the reconciliation of opening and closing investments. For realised       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 gains/losses, we tested a sample of disposal proceeds by agreeing the proceeds to bank statements and we re-performed the calculation of a sample of realised             
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 gains/losses. In addition, we tested a sample of dividend receipts by agreeing the dividend rates from all investments to independent third party sources. To test for    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 completeness, we tested that the appropriate dividends had been received in the year by reference to independent data of dividends declared for all listed investments    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 during the year. Our testing did not identify any unrecorded dividends. We tested the allocation and presentation of dividend income between the revenue and capital      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 return columns of the Income Statement in line with the requirements set out in the AIC SORP. We did not find any special dividends that were not treated in accordance   
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 with the AIC SORP. No material misstatements were identified from this testing.                                                                                           
 Valuation and existence of investments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 Refer to the Audit & Risk Committee Report), the Accounting Policies) and the Notes to the Financial Statements). The investment portfolio at 31 March 2022 principally comprised listed equity investments and unquoted debt and equity investments totalled £2,379,848,000. We focused on the valuation and existence of investments because investments represent the principal element of the net asset value as disclosed in the Statement of Financial Position in the financial statements.                                                                                                                                                                                                                                                                                                                                                                                                                              We tested the valuation of all listed investments by agreeing the prices used in the valuation to independent third party sources. We tested the existence of all listed  
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 investments by agreeing the holdings of each investment to an independent confirmation from the Custodian and Prime Broker, J.P. Morgan Securities LLC, as at 31 March    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 2022. For unquoted investments we understood and evaluated the valuation methodology applied, by reference to the International Private Equity and Venture Capital        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Valuation guidelines (IPEV), and tested the techniques used by the Directors in determining the fair value of unquoted investments. Our testing, performed on a sample    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 basis, included: We found that the Directors’ valuations of unquoted investments were materially consistent with the IPEV guidelines and that the assumptions used to     
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 derive the valuations within the financial statements were reasonable based on the investee’s circumstances or consistent with appropriate third party sources. No        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 material misstatements were identified from this testing. We tested the existence of the unquoted investment portfolio by agreeing a sample of the holdings to            
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 independently obtained third party confirmations as at 31 March 2022. No variances were identified from this testing.                                                     

How we tailored the audit scope

We tailored the scope of our audit to ensure that we performed enough work to
be able to give an opinion on the financial statements as a whole, taking into
account the structure of the Company, the accounting processes and controls,
and the industry in which it operates.

As part of designing our audit, we determined materiality and assessed the
risks of material misstatement in the financial statements. In particular, we
looked at where the Directors made subjective judgements, for example in
respect of significant accounting estimates that involved making assumptions
and considering future events that are inherently uncertain.

Materiality

The scope of our audit was influenced by our application of materiality. We
set certain quantitative thresholds for materiality. These, together with
qualitative considerations, helped us to determine the scope of our audit and
the nature, timing and extent of our audit procedures on the individual
financial statement line items and disclosures and in evaluating the effect of
misstatements, both individually and in aggregate on the financial statements
as a whole.

Based on our professional judgement, we determined materiality for the
financial statements as a whole as follows:

 Overall Company materiality      £22,682,000 (2021: £23,600,000).                                                                                                                                                                                                                                                           
 How we determined it             approximately 1% of net assets                                                                                                                                                                                                                                                             
 Rationale for benchmark applied  We have applied this benchmark, a generally accepted auditing practice for investment trust audits, in the absence of indicators that an alternative benchmark would be appropriate and because we believe this provides an appropriate and consistent year- on-year basis for our audit.  

We use performance materiality to reduce to an appropriately low level the
probability that the aggregate of uncorrected and undetected misstatements
exceeds overall materiality. Specifically, we use performance materiality in
determining the scope of our audit and the nature and extent of our testing of
account balances, classes of transactions and disclosures, for example in
determining sample sizes. Our performance materiality was 75% (2021: 75%) of
overall materiality, amounting to £17,011,000 (2021: £17,700,000) for the
Company financial statements.

In determining the performance materiality, we considered a number of factors
- the history of misstatements, risk assessment and aggregation risk and the
effectiveness of controls - and concluded that an amount at the upper end of
our normal range was appropriate.

We agreed with the Audit & Risk Committee that we would report to them
misstatements identified during our audit above £1,134,000 (2021:
£1,180,000) as well as misstatements below that amount that, in our view,
warranted reporting for qualitative reasons.

Conclusions relating to going concern

Our evaluation of the Directors’ assessment of the Company’s ability to
continue to adopt the going concern basis of accounting included:
* evaluating the Directors’ updated risk assessment and considering whether
it addressed relevant threats, including the ongoing impact of Covid-19 and
the heightened economic uncertainty as a result of recent global events;
* evaluating the Directors’ assessment of potential operational impacts,
considering their consistency with other available information and our
understanding of the business and assessed the potential impact on the
financial statements;
* reviewing the Directors’ assessment of the Company’s financial position
in the context of its ability to meet future expected operating expenses and
debt repayments, their assessment of liquidity as well as their review of the
operational resilience of the Company and oversight of key third-party service
providers; and
* assessing the implications of reductions in NAV as a result of market
performance on the ongoing ability of the Company to operate.
Based on the work we have performed, we have not identified any material
uncertainties relating to events or conditions that, individually or
collectively, may cast significant doubt on the Company’s ability to
continue as a going concern for a period of at least twelve months from when
the financial statements are authorised for issue.

In auditing the financial statements, we have concluded that the directors’
use of the going concern basis of accounting in the preparation of the
financial statements is appropriate.

However, because not all future events or conditions can be predicted, this
conclusion is not a guarantee as to the Company’s ability to continue as a
going concern.

In relation to the directors’ reporting on how they have applied the UK
Corporate Governance Code, we have nothing material to add or draw attention
to in relation to the directors’ statement in the financial statements about
whether the directors considered it appropriate to adopt the going concern
basis of accounting.

Our responsibilities and the responsibilities of the directors with respect to
going concern are described in the relevant sections of this report.

Reporting on other information

The other information comprises all of the information in the Annual Report
other than the financial statements and our auditors’ report thereon. The
directors are responsible for the other information. Our opinion on the
financial statements does not cover the other information and, accordingly, we
do not express an audit opinion or, except to the extent otherwise explicitly
stated in this report, any form of assurance thereon.

In connection with our audit of the financial statements, our responsibility
is to read the other information and, in doing so, consider whether the other
information is materially inconsistent with the financial statements or our
knowledge obtained in the audit, or otherwise appears to be materially
misstated. If we identify an apparent material inconsistency or material
misstatement, we are required to perform procedures to conclude whether there
is a material misstatement of the financial statements or a material
misstatement of the other information. If, based on the work we have
performed, we conclude that there is a material misstatement of this other
information, we are required to report that fact. We have nothing to report
based on these responsibilities.

With respect to the Strategic report and the Report of the Directors, we also
considered whether the disclosures required by the UK Companies Act 2006 have
been included.

Based on our work undertaken in the course of the audit, the Companies Act
2006 requires us also to report certain opinions and matters as described
below.

Strategic report and the Report of the Directors

In our opinion, based on the work undertaken in the course of the audit, the
information given in the Strategic report and the Report of the Directors for
the year ended 31 March 2022 is consistent with the financial statements and
has been prepared in accordance with applicable legal requirements.

In light of the knowledge and understanding of the Company and its environment
obtained in the course of the audit, we did not identify any material
misstatements in the Strategic report and the Report of the Directors.

Directors’ Remuneration

In our opinion, the part of the Directors’ Remuneration Report to be audited
has been properly prepared in accordance with the Companies Act 2006.

Corporate governance statement

The Listing Rules require us to review the directors’ statements in relation
to going concern, longer-term viability and that part of the corporate
governance statement relating to the Company’s compliance with the
provisions of the UK Corporate Governance Code specified for our review. Our
additional responsibilities with respect to the corporate governance statement
as other information are described in the Reporting on other information
section of this report.

Based on the work undertaken as part of our audit, we have concluded that each
of the following elements of the corporate governance statement is materially
consistent with the financial statements and our knowledge obtained during the
audit, and we have nothing material to add or draw attention to in relation
to:
* The Directors’ confirmation that they have carried out a robust assessment
of the emerging and principal risks;
* The disclosures in the Annual Report that describe those principal risks,
what procedures are in place to identify emerging risks and an explanation of
how these are being managed or mitigated;
* The Directors’ statement in the financial statements about whether they
considered it appropriate to adopt the going concern basis of accounting in
preparing them, and their identification of any material uncertainties to the
Company’s ability to continue to do so over a period of at least twelve
months from the date of approval of the financial statements;
* The Directors’ explanation as to their assessment of the Company’s
prospects, the period this assessment covers and why the period is
appropriate; and
* The Directors’ statement as to whether they have a reasonable expectation
that the Company will be able to continue in operation and meet its
liabilities as they fall due over the period of its assessment, including any
related disclosures drawing attention to any necessary qualifications or
assumptions.
Our review of the Directors’ statement regarding the longer-term viability
of the group was substantially less in scope than an audit and only consisted
of making inquiries and considering the Directors’ process supporting their
statement; checking that the statement is in alignment with the relevant
provisions of the UK Corporate Governance Code; and considering whether the
statement is consistent with the financial statements and our knowledge and
understanding of the Company and its environment obtained in the course of the
audit.

In addition, based on the work undertaken as part of our audit, we have
concluded that each of the following elements of the corporate governance
statement is materially consistent with the financial statements and our
knowledge obtained during the audit:
* The Directors’ statement that they consider the Annual Report, taken as a
whole, is fair, balanced and understandable, and provides the information
necessary for the members to assess the Company’s position, performance,
business model and strategy;
* The section of the Annual Report that describes the review of effectiveness
of risk management and internal control systems; and
* The section of the Annual Report describing the work of the Audit & Risk
Committee.
We have nothing to report in respect of our responsibility to report when the
directors’ statement relating to the Company’s compliance with the Code
does not properly disclose a departure from a relevant provision of the Code
specified under the Listing Rules for review by the auditors.

Responsibilities for the financial statements and the audit

Responsibilities of the directors for the financial statements

As explained more fully in the Statement of Directors’ Responsibilities, the
directors are responsible for the preparation of the financial statements in
accordance with the applicable framework and for being satisfied that they
give a true and fair view. The directors are also responsible for such
internal control as they determine is necessary to enable the preparation of
financial statements that are free from material misstatement, whether due to
fraud or error.

In preparing the financial statements, the directors are responsible for
assessing the Company’s ability to continue as a going concern, disclosing,
as applicable, matters related to going concern and using the going concern
basis of accounting unless the directors either intend to liquidate the
Company or to cease operations, or have no realistic alternative but to do so.

Auditors’ responsibilities for the audit of the financial statements

Our objectives are to obtain reasonable assurance about whether the financial
statements as a whole are free from material misstatement, whether due to
fraud or error, and to issue an auditors’ report that includes our opinion.
Reasonable assurance is a high level of assurance, but is not a guarantee that
an audit conducted in accordance with ISAs (UK) will always detect a material
misstatement when it exists. Misstatements can arise from fraud or error and
are considered material if, individually or in the aggregate, they could
reasonably be expected to influence the economic decisions of users taken on
the basis of these financial statements.

Irregularities, including fraud, are instances of non-compliance with laws and
regulations. We design procedures in line with our responsibilities, outlined
above, to detect material misstatements in respect of irregularities,
including fraud. The extent to which our procedures are capable of detecting
irregularities, including fraud, is detailed below.

Based on our understanding of the Company and industry, we identified that the
principal risks of non-compliance with laws and regulations related to
breaches of section 1158 of the Corporation Tax Act 2010, and we considered
the extent to which non-compliance might have a material effect on the
financial statements. We also considered those laws and regulations that have
a direct impact on the financial statements such as the Companies act 2006. We
evaluated management’s incentives and opportunities for fraudulent
manipulation of the financial statements (including the risk of override of
controls), and determined that the principal risks were related to posting
inappropriate journal entries to increase revenue (investment income and
capital gains) or to increase net asset value, and management bias in
accounting estimates. Audit procedures performed by the engagement team
included:
* discussions with the AIFM and the Audit & Risk Committee, including
consideration of known or suspected instances of non-compliance with laws and
regulation and fraud;
* reviewing relevant meeting minutes, including those of the Audit & Risk
Committee;
* assessment of the Company’s compliance with the requirements of section
1158 of the Corporation Tax Act 2010, including recalculation of numerical
aspects of the eligibility conditions;
* challenging assumptions and judgements made by management in their
significant accounting estimates, in particular in relation to the valuation
of unquoted investments (see related key audit matter above);
* identifying and testing journal entries, in particular any material or
revenue-impacting manual journal entries posted as part of the Annual Report
preparation process; and
* designing audit procedures to incorporate unpredictability around the
nature, timing or extent of our testing.
There are inherent limitations in the audit procedures described above. We are
less likely to become aware of instances of non-compliance with laws and
regulations that are not closely related to events and transactions reflected
in the financial statements. Also, the risk of not detecting a material
misstatement due to fraud is higher than the risk of not detecting one
resulting from error, as fraud may involve deliberate concealment by, for
example, forgery or intentional misrepresentations, or through collusion.

Our audit testing might include testing complete populations of certain
transactions and balances, possibly using data auditing techniques. However,
it typically involves selecting a limited number of items for testing, rather
than testing complete populations. We will often seek to target particular
items for testing based on their size or risk characteristics. In other cases,
we will use audit sampling to enable us to draw a conclusion about the
population from which the sample is selected.

A further description of our responsibilities for the audit of the financial
statements is located on the FRC’s website at:
www.frc.org.uk/auditorsresponsibilities. This description forms part of our
auditors’ report.

Use of this report

This report, including the opinions, has been prepared for and only for the
Company’s members as a body in accordance with Chapter 3 of Part 16 of the
Companies Act 2006 and for no other purpose. We do not, in giving these
opinions, accept or assume responsibility for any other purpose or to any
other person to whom this report is shown or into whose hands it may come save
where expressly agreed by our prior consent in writing.

OTHER REQUIRED REPORTING

Companies Act 2006 exception reporting

Under the Companies Act 2006 we are required to report to you if, in our
opinion:
* we have not obtained all the information and explanations we require for our
audit; or
* adequate accounting records have not been kept by the Company, or returns
adequate for our audit have not been received from branches not visited by us;
or
* certain disclosures of directors’ remuneration specified by law are not
made; or
* the financial statements and the part of the Directors’ Remuneration
Report to be audited are not in agreement with the accounting records and
returns.
We have no exceptions to report arising from this responsibility.

Appointment

Following the recommendation of the Audit & Risk Committee, we were appointed
by the members on 14 July 2014 to audit the financial statements for the year
ended 31 March 2015 and subsequent financial periods. The period of total
uninterrupted engagement is 8 years, covering the years ended 31 March 2015 to
31 March 2022.

Allan McGrath (Senior Statutory Auditor)
for and on behalf of PricewaterhouseCoopers LLP
Chartered Accountants and Statutory Auditors
Edinburgh

26 May 2022

INCOME STATEMENT

FOR THE YEAR ENDED 31 MARCH 2022

                                                                               2022                           2021           
                                                                 Revenue    Capital      Total   Revenue   Capital     Total 
                                                         Notes     £’000      £’000      £’000     £’000     £’000     £’000 
 (Losses)/gains on investments                               9         –  (152,475)  (152,475)         –   517,267   517,267 
 Exchange losses on currency balances                                  –    (6,342)    (6,342)         –   (6,076)   (6,076) 
 Income from investments                                     2    23,471          –     23,471    19,247         –    19,247 
 AIFM, portfolio management and performance fees             3     (938)      1,061        123     (853)  (47,963)  (48,816) 
 Other expenses                                              4   (1,305)      (529)    (1,834)   (1,338)     (155)   (1,493) 
 Net return/(loss) before finance charges and taxation            21,228  (158,285)  (137,057)    17,056   463,073   480,129 
 Finance costs                                               5      (40)      (761)      (801)      (20)     (379)     (399) 
 Net return/(loss) before taxation                                21,188  (159,046)  (137,858)    17,036   462,694   479,730 
 Taxation on net return                                      6   (3,668)          –    (3,668)   (2,712)         –   (2,712) 
 Net return/(loss) after taxation                                 17,520  (159,046)  (141,526)    14,324   462,694   477,018 
 Return/(loss) per share                                     7     26.8p    (243.5)    (216.7)     24.1p    777.8p    801.9p 

The “Total” column of this statement is the Income Statement of the
Company. The “Revenue” and “Capital” columns are supplementary to this
and are prepared under guidance published by The Association of Investment
Companies.

All revenue and capital items in the above statement derive from continuing
operations.

The Company has no recognised gains and losses other than those shown above
and therefore no separate Statement of Total Comprehensive Income has been
presented.

The accompanying notes are an integral part of these statements.

STATEMENT OF CHANGES IN EQUITY

FOR THE YEAR ENDED 31 MARCH 2022

                                                                             Capital     Share                                 Total 
                                                                   Share  redemption   premium    Capital   Revenue    shareholders’ 
                                                                 capital     reserve   account    reserve   reserve            funds 
                                                                   £’000       £’000     £’000      £’000     £’000            £’000 
 At 1 April 2021                                                  16,078       8,221   796,357  1,542,628    18,141        2,381,425 
 Net (loss)/return after taxation                                      –           –         –  (159,046)    17,520        (141,526) 
 Final dividend paid in respect of year ended 31 March 2021            –           –         –          –  (10,085)         (10,085) 
 Interim dividend paid in respect of year ended 31 March 2022          –           –         –          –   (4,586)          (4,586) 
 New shares issued                                                   307           –    45,242          –         –           45,549 
 Shares purchased for treasury                                         –           –         –    (2,544)         –          (2,544) 
 At 31 March 2022                                                 16,385       8,221   841,599  1,381,038    20,990        2,268,233 

FOR THE YEAR ENDED 31 MARCH 2021

                                                                                    Capital     Share                                 Total 
                                                                          Share  redemption   premium    Capital   Revenue    shareholders’ 
                                                                        capital     reserve   account    reserve   reserve            funds 
                                                                          £’000       £’000     £’000      £’000     £’000            £’000 
 At 1 April 2020                                                         13,406       8,221   418,441  1,079,934    18,296        1,538,298 
 Net return after taxation                                                    –           –         –    462,694    14,324          477,018 
 Second interim dividend paid in respect of year ended 31 March 2020          –           –         –          –  (10,512)         (10,512) 
 Interim dividend paid in respect of year ended 31 March 2021                 –           –         –          –   (3,967)          (3,967) 
 New shares issued                                                        2,672           –   377,916          –         –          380,588 
 At 31 March 2021                                                        16,078       8,221   796,357  1,542,628    18,141        2,381,425 

STATEMENT OF FINANCIAL POSITION

As at 31 March 2022

                                                               2022       2021 
                                                   Notes      £’000      £’000 
 Fixed assets                                                                  
 Investments                                           9  2,379,848  2,416,038 
 Derivative – OTC swaps                           9 & 10        283     18,864 
                                                          2,380,131  2,434,902 
 Current assets                                                                
 Debtors                                              11     14,724     18,172 
 Cash                                                        26,594     29,595 
                                                             41,318     47,767 
 Current liabilities                                                           
 Creditors: amounts falling due within one year       12  (147,804)   (92,932) 
 Derivative – OTC swaps                           9 & 10    (5,412)    (8,312) 
                                                          (153,216)  (101,244) 
 Net current liabilities                                  (111,898)   (53,477) 
 Total net assets                                         2,268,233  2,381,425 
 Capital and reserves                                                          
 Share capital                                        13     16,385     16,078 
 Capital redemption reserve                                   8,221      8,221 
 Share premium account                                      841,599    796,357 
 Capital reserve                                      17  1,381,038  1,542,628 
 Revenue reserve                                             20,990     18,141 
 Total shareholders' funds                                2,268,233  2,381,425 
 Net asset value per share                            14   3,465.2p   3,703.0p 

The financial statements were approved by the Board of Directors and
authorised for issue on 26 May 2022 and were signed on its behalf by:

Sir Martin Smith

Chairman

The accompanying notes are an integral part of this statement.

Worldwide Healthcare Trust PLC – Company Registration Number 3023689
(Registered in England)

STATEMENT OF CASH FLOWS

FOR THE YEAR ENDED 31 MARCH 2022

                                                                       2022         2021 
                                                         Notes        £’000        £’000 
 Net cash (outflow)/inflow from operating activities        18     (13,329)          931 
 Purchases of investments and derivatives                       (1,330,279)  (1,709,998) 
 Sales of investments and derivatives                             1,253,138    1,481,508 
 Realised (loss)/gain on foreign exchange transactions              (5,541)        3,205 
 Net cash outflow from investing activities                        (82,682)    (225,285) 
 Issue of shares                                            13       48,126      378,728 
 Shares repurchased                                         13      (2,544)            – 
 Equity dividends paid                                             (14,671)     (14,479) 
 Interest paid                                                        (801)        (399) 
 Net cash inflow from financing activities                           30,110      363,850 
 (Increase)/decrease in net debt                                   (65,901)      139,496 

Cash flows from operating activities include interest received of £968,000
(2021: £1,265,000) and dividends received of £23,853,000 (2021:
£18,907,000).

RECONCILIATION OF NET CASH FLOW MOVEMENT TO MOVEMENT IN NET DEBT

                                                                2022       2021 
                                                               £’000      £’000 
 (Increase)/decrease in net debt resulting from cashflows   (65,901)    139,496 
 Losses on foreign currency cash and cash equivalents          (801)    (9,281) 
 Movement in net debt in the year                           (66,702)    130,215 
 Net debt at 1 April                                        (20,301)  (150,516) 
 Net debt at 31 March                                       (87,003)   (20,301) 

Net debt includes the bank overdraft of £113,597,000 (2021: £49,896,000)
(see note 12) and cash as per the balance sheet of £26,594,000 (2021:
£29,595,000).

The accompanying notes are an integral part of this statement.

NOTES TO THE FINANCIAL STATEMENTS

1. ACCOUNTING POLICIES

The principal accounting policies, all of which have been applied consistently
throughout the year in the preparation of these financial statements, are set
out below:

(A) Basis of preparation

These financial statements have been prepared in accordance with the Companies
Act 2006, FRS 102 ‘The Financial Reporting Standard applicable in the UK and
Ireland’ (‘UK GAAP’) and the guidelines set out in the Statement of
Recommended Practice (‘SORP’), published in February 2021, for Investment
Trust Companies and Venture Capital Trusts issued by the Association of
Investment Companies (‘AIC’), the historical cost convention, as modified
by the valuation of investments and derivatives at fair value. The Board has
considered a detailed assessment of the Company’s ability to meet its
liabilities as they fall due, including stress and liquidity tests which
modelled the effects of substantial falls in markets and significant
reductions in market liquidity (including further stressing the current
economic conditions caused by the coronavirus pandemic) on the Company’s
financial position and cash flows. Further information on the assumptions used
in the stress scenarios is provided in the Audit & Risk Committee report. The
results of the tests showed that the Company would have sufficient cash, or
the ability to liquidate a sufficient proportion of its listed holdings, to
meet its liabilities as they fall due. Based on the information available to
the Directors at the time of this report, including the results of the stress
tests, the Company’s cash balances, and the liquidity of the Company’s
listed investments, the Directors are satisfied that the Company has adequate
financial resources to continue in operation for at least the next 12 months
from the date of approval of these financial statements and that, accordingly,
it is appropriate to adopt the going concern basis in preparing these
financial statements.

The Company’s financial statements are presented in sterling, being the
functional and presentational currency of the Company. All values are rounded
to the nearest thousand pounds (£’000) except where otherwise indicated.

In addition, investments and derivatives held at fair value are categorised
into a fair value hierarchy based on the degree to which the inputs to the
fair value measurements are observable and the significance of the inputs to
the fair value measurement in its entirety, which are described as follows:
* Level 1 – Quoted prices in active markets.
* Level 2 – Inputs other than quoted prices included within Level 1 that are
observable (i.e. developed using market data), either directly or indirectly.
* Level 3 – Inputs are unobservable (i.e. for which market data is
unavailable).
Presentation of the Income Statement

In order to reflect better the activities of an investment trust company and
in accordance with the SORP, supplementary information which analyses the
Income Statement between items of a revenue and capital nature has been
presented alongside the Income Statement. The net revenue return is the
measure the Directors believe appropriate in assessing the Company’s
compliance with certain requirements set out in Sections 1158 and 1159 of the
Corporation Tax Act 2010.

Critical Accounting Judgements and Key Sources of Estimation Uncertainty

Critical accounting judgements and key sources of estimation uncertainty used
in preparing the financial information are continually evaluated and are based
on historical experience and other factors, including expectations of future
events that are believed to be reasonable. The resulting estimates will, by
definition, seldom equal the related actual results.

In the course of preparing the financial statements, the only key source of
estimation uncertainty in the process of applying the Company’s accounting
policies, is in relation to the valuation of the unquoted (Level 3)
investments. The nature of estimation means that the actual outcomes could
differ from those estimates, possibly significantly. The estimates relate to
the investments where there is no appropriate market price i.e. the private
investments. Whilst the board considers the methodologies and assumptions
adopted in the valuation are supportable, reasonable and robust, because of
the inherent uncertainty of valuation, those estimated values may differ
significantly from the values that would have been used had a ready market for
the investment existed. As at 31 March 2022, there is no single key assumption
used in the valuation of the unquoted investments, or other key source of
estimation uncertainty, that, in the Directors’ opinion has a significant
risk of causing a material adjustment to the carrying values of assets and
liabilities within the next financial year.

Unquoted investments are all valued in line with the accounting policy set out
below.

(B) Investments

Investments are measured under FRS 102 and are measured initially, and at
subsequent reporting dates, at fair value. Investments are recognised and
de-recognised at trade date where a purchase or sale is under a contract whose
terms require delivery within the time frame established by the market
concerned. Changes in fair value and gains or losses on disposal are included
in the Income Statement as a capital item.

For quoted securities fair value is either bid price or last traded price,
depending on the convention of the exchange on which the investment is listed.

Fair value is the price for which an asset could be exchanged between
knowledgeable, willing parties in an arm’s length transaction. In estimating
the fair value of unquoted investments, the AIFM and Board apply valuation
techniques which are appropriate in light of the nature, facts and
circumstances of the investment, and use reasonable current market data and
inputs combined with judgement and assumptions and apply these consistently.
The following principles used in determining the valuation of unquoted
investments, are consistent with the International Private Equity and Venture
Capital Valuation (“IPEV”) Guidelines. The assumptions and estimates made
in determining the fair value of each unquoted investment are considered at
least each six months or sooner if there is a triggering event. An example of
where a valuation would be considered out of the six-month cycle is the
success or failure of a drug under development to meet an anticipated outcome
of its trial, announcement of the company undergoing an initial public
offering, or other performance against tangible development milestones.

The primary valuation method applied in the valuation of the unquoted
investments is the probability-weighted expected return method (PWERM), which
considers on a probability weighted basis the future outcomes for the
investment. When using the PWERM method significant judgements are made in
estimating the various inputs into the model and recognising the sensitivity
of such estimates. Examples of the factors where significant judgement is made
include, but are not limited to, the probability assigned to potential future
outcomes; discount rates; and, the likely exit scenarios for the investor
company, for example, IPO or trade sale.

Where the investment being valued was itself made recently, or there has been
a third party transaction in the investment, the price of the transaction may
provide a good indication of fair value. Using the Price of Recent Investment
technique is not a default and at each reporting date the fair value of recent
investments is estimated to assess whether changes or events subsequent to the
relevant transaction would imply a material change in the investment’s fair
value.

When using the price of a recent transaction in the valuations the Company
looks to ‘re-calibrate’ this price at each valuation point by reviewing
progress within the investment, comparing against the initial investment
thesis, assessing if there are any significant events or milestones that would
indicate the value of the investment value has changed materially and
considering whether an alternative methodology would be more appropriate.

(C) Derivative financial instruments

The Company uses derivative financial instruments (namely put and call options
and equity swaps).

All derivative instruments are valued initially, and at subsequent reporting
dates, at fair value in the Statement of Financial Position.

The equity swaps are accounted for as Fixed Assets or Current Liabilities.

All gains and losses on over-the-counter (OTC) equity swaps are accounted for
as gains or losses on investments. Where there has been a re-positioning of
the swap, gains and losses are accounted for on a realised basis. All such
gains and losses have been debited or credited to the capital column of the
Income Statement.

Cash collateral held by counterparties is included within cash, except where
there is a right of offset against the overdraft-facility.

(D) Investment income

Dividends receivable are recognised on the ex-dividend date. Where no
ex-dividend date is quoted, dividends are recognised when the Company’s
right to receive payment is established. Foreign dividends are grossed up at
the appropriate rate of withholding tax, with the withholding tax recognised
in the taxation charge.

Income from fixed interest securities is recognised on a time apportionment
basis so as to reflect the effective interest rate. Deposit interest is
accounted for on an accruals basis.

(E) Expenses

All expenses are accounted for on an accruals basis. Expenses are charged
through the revenue column of the Income Statement except as follows:
* expenses which are incidental to the acquisition or disposal of an
investment are charged to the capital column of the Income Statement; and
* expenses are charged to the capital column of the Income Statement where a
connection with the maintenance or enhancement of the value of the investments
can be demonstrated. In this respect the portfolio management and AIFM fees
have been charged to the Income Statement in line with the Board’s expected
long-term split of returns, in the form of capital gains and income, from the
Company’s portfolio. As a result 5% of the portfolio management and AIFM
fees are charged to the revenue column of the Income Statement and 95% are
charged to the capital column of the Income Statement.
Any performance fee is charged in full to the capital column of the Income
Statement.

(F) Finance costs

Finance costs are accounted for on an accruals basis. Finance costs are
charged to the Income Statement in line with the Board’s expected long-term
split of returns, in the form of capital gains and income, from the
Company’s portfolio. As a result 5% of the finance costs are charged to the
revenue column of the Income Statement and 95% are charged to the capital
column of the Income Statement. Finance charges are accounted for on an
accruals basis in the Income Statement using the effective interest rate
method and are added to the carrying amount of the instrument to the extent
that they are not settled in the period in which they arise.

(G) Taxation

The tax effect of different items of expenditure is allocated between capital
and revenue using the marginal basis.

Deferred taxation is provided on all timing differences that have originated
but not been reversed by the Statement of Financial Position date other than
those differences regarded as permanent. This is subject to deferred tax
assets only being recognised when it is probable that there will be suitable
profits from which the reversal of timing differences can be deducted. Any
liability to deferred tax is provided for at the rate of tax enacted or
substantially enacted.

(H) Foreign currency

Transactions recorded in overseas currencies during the year are translated
into sterling at the appropriate daily exchange rates. Assets and liabilities
denominated in overseas currencies at the Statement of Financial Position date
are translated into sterling at the exchange rates ruling at that date.

Exchange gains/losses on foreign currency balances

Any gains or losses on the translation of foreign currency balances, including
the foreign currency overdraft, whether realised or unrealised, are taken to
the capital or the revenue column of the Income Statement, depending on
whether the gain or loss is of a capital or revenue nature.

(I) Capital redemption reserve

This reserve arose when ordinary shares were redeemed by the Company and
subsequently cancelled. When ordinary shares are redeemed by the Company and
subsequently cancelled, an amount equal to the par value of the ordinary share
capital is transferred from the ordinary share capital to the capital
redemption reserve.

(J) Capital reserve

The following are transferred to this reserve:
* gains and losses on the disposal of investments;
* exchange differences of a capital nature, including the effects of changes
in exchange rates on foreign currency borrowings;
* expenses, together with the related taxation effect, in accordance with the
above policies; and
* changes in the fair value of investments and derivatives.
This reserve can be used to distribute realised capital profits by way of
dividend or share buy backs. Any gains in the fair value of investments that
are not readily convertible to cash are treated as unrealised gains in the
capital reserve. Distributions are only payable out of the capital reserve if
capital reserves are greater than the proposed distribution and positive on
the date of distribution.

(K) Revenue reserve

The revenue reserve is distributable by way of dividend. Dividends are only
payable out of the revenue reserve if revenue reserves are greater than the
proposed dividend and positive on the date of distribution.

(L) Dividend payments

Dividends paid by the Company on its shares are recognised in the financial
statements in the year in which they become payable and are shown in the
Statement of Changes in Equity.

(M) Cash and cash equivalents

Cash comprises cash at bank and cash equivalents are short-term, highly liquid
investments that are readily convertible to known amounts of cash and are
subject to an insignificant risk of changes in value.

Bank overdrafts are considered as a component of cash and cash equivalents as
they are repayable on demand and form an integral part of the Company’s cash
management.

2. INCOME FROM INVESTMENTS

                                     2022      2021 
                                    £’000     £’000 
 Income from investments                            
 Overseas dividends                19,678    16,730 
 Fixed interest income                772       999 
 UK dividends                       2,825     1,449 
                                   23,275    19,178 
 Other income                                       
 Derivatives                          151         – 
 Deposit interest                      45        24 
 Income from liquidity stocks           –        45 
 Total income from investments     23,471    19,247 
 Total income comprises:                            
 Dividends                         22,503    18,179 
 Interest                             968     1,068 
                                   23,471    19,247 

3. AIFM, PORTFOLIO MANAGEMENT AND PERFORMANCE FEES

                                                              2022                          2021 
                                       Revenue   Capital     Total   Revenue   Capital     Total 
                                         £’000     £’000     £’000     £’000     £’000     £’000 
 AIFM fee                                  160     3,046     3,206       152     2,892     3,044 
 Portfolio management fee                  778    14,781    15,559       701    13,323    14,024 
 Performance fee (reversal)/charge*          –  (18,888)  (18,888)         –    31,748    31,748 
                                           938   (1,061)     (123)       853    47,963    48,816 

*          During the year ended 31 March 2022, due to
underperformance against the Benchmark, a reversal of prior period performance
fee provisions totalling £18,888,000 occurred (2021: charge of £31,748,000).

Further details on the above fees are set out in the Strategic Report and the
Report of the Directors.

4. OTHER EXPENSES

                                                                                      2022      2021 
                                                                                     £’000     £’000 
 Directors’ remuneration                                                               207       222 
 Employer’s NIC on Directors’ remuneration                                              20        20 
 Auditors’ remuneration for the audit of the Company’s financial statements             47        49 
 Auditors’ remuneration for non-audit services                                           5         – 
 Depositary and custody fees                                                           213       177 
 Listing fees*                                                                          77       461 
 Registrar fees                                                                         63        48 
 Legal and professional costs                                                          255        78 
 Broker fees                                                                           117        30 
 Other costs                                                                           301       253 
                                                                                     1,305     1,338 
 Professional fees (Capital)^                                                          529       155 
                                                                                     1,834     1,493 

Details of the amounts paid to Directors are included in the Directors’
Remuneration Report.

*          2021 includes £405,000 in respect of London Stock
Exchange block listing fees required as a result of the issuance of new shares
by the Company during the year.

^         Professional fees in respect of acquisition of unquoted
investments. These fees do not form part of the ongoing charge ratio. See
Glossary.

5. FINANCE COSTS

                                         2022                          2021 
                  Revenue   Capital     Total   Revenue   Capital     Total 
                    £’000     £’000     £’000     £’000     £’000     £’000 
 Finance costs         40       761       801        20       379       399 

6. TAXATION ON NET RETURN

(A) Analysis of charge in year

                                                              2022                          2021 
                                       Revenue   Capital     Total   Revenue   Capital     Total 
                                         £’000     £’000     £’000     £’000     £’000     £’000 
 Corporation tax at 19% (2020: 19%)          –         –         –         –         –         – 
 Overseas taxation                       3,668         –     3,668     2,712         –     2,712 
                                         3,668         –     3,668     2,712         –     2,712 

(B) Factors affecting the tax charge for the year

Approved investment trusts are exempt from tax on capital gains made within
the Company.

The tax charged for the year is lower (2021: lower) than the standard rate of
corporation tax of 19% (2021: 19%).

The difference is explained below.

                                                                2022                          2021 
                                       Revenue    Capital      Total   Revenue   Capital     Total 
                                         £’000      £’000      £’000     £’000     £’000     £’000 
 Net return before taxation             21,188  (159,046)  (137,858)    17,036   462,694   479,730 
 Corporation tax at 19% (2021: 19%)      4,026   (30,219)   (26,193)     3,237    87,912    91,149 
 Non-taxable gains on investments            –     30,175     30,175         –  (97,126)  (97,126) 
 Overseas withholding taxation           3,668          –      3,668     2,712         –     2,712 
 Non taxable dividends                 (4,276)          –    (4,276)   (3,468)         –   (3,468) 
 Excess management expenses                250         44        294       231     9,214     9,445 
 Total tax charge                        3,668          –      3,668     2,712         –     2,712 

(C) Provision for deferred tax

No provision for deferred taxation has been made in the current or prior year.
The Company has not provided for deferred tax on capital profits and losses
arising on the revaluation or disposal of investments, as it is exempt from
tax on these items because of its status as an investment trust company.

The Company has not recognised a deferred tax asset of £45,055,000 (25% tax
rate) (2021: £33,851,000 (19% tax rate)) as a result of excess management
expenses and loan expenses. It is not anticipated that these excess expenses
will be utilised in the foreseeable future.

7. RETURN PER SHARE

                                                                             2022        2021 
                                                                            £’000       £’000 
 The return per share is based on the following figures:                                      
 Revenue return                                                            17,520      14,324 
 Capital (loss)/return                                                  (159,046)     462,694 
                                                                        (141,526)     477,018 
 Weighted average number of ordinary shares in issue during the year   65,307,132  59,487,545 
 Revenue return per ordinary share                                          26.8p       24.1p 
 Capital (loss)/return per ordinary share                                (243.5p)      777.8p 
                                                                         (216.7p)      801.9p 

The calculation of the total, revenue and capital (loss)/return per ordinary
share is carried out in accordance with IAS 33, “Earnings per Share”, in
accordance with the requirements of FRS 102.

8. DIVIDENDS

Under UK Company Law, final dividends are not recognised until they are
approved by shareholders and interim dividends are not recognised until they
are paid. They are also debited directly from reserves. Amounts recognised as
distributable in these financial statements were as follows:

                                                                          2022      2021 
                                                                         £’000     £’000 
 Second interim dividend in respect of the year ended 31 March 2020          –    10,512 
 Interim dividend in respect of the year ended 31 March 2021                 –     3,967 
 Final dividend in respect of the year ended 31 March 2021              10,085         – 
 Interim dividend in respect of the year ended 31 March 2022             4,586         – 
                                                                        14,671    14,479 

In respect of the year ended 31 March 2022, an interim dividend of 7.0p per
share was paid on 11 January 2022. A final dividend of 19.5p will be payable,
subject to shareholder approval, on 13 July 2022, the associated ex dividend
date will be 1 June 2022. The total dividends payable in respect of the year
ended 31 March 2022 amount to 26.5p per share (2021: 22.0p per share). The
aggregate cost of the final dividend, based on the number of shares in issue
at 25 May 2022, will be £12,721,000. In accordance with FRS 102 dividends
will be reflected in the financial statements for the year in which they
become payable. Total dividends in respect of the financial year, which is the
basis on which the requirements of s1158 of the Corporation Tax Act 2010 are
considered, are set out below.

                                                                          2022      2021 
                                                                         £’000     £’000 
 Revenue available for distribution by way of dividend for the year     17,520    14,324 
 Interim dividend in respect of the year ended 31 March 2022           (4,586)         – 
 Final dividend in respect of the year ended 31 March 2022*           (12,721)         – 
 Interim dividend in respect of the year ended 31 March 2021                 –   (3,967) 
 Final dividend in respect of the year ended 31 March 2021                   –  (10,085) 
 Net retained revenue                                                      213       272 

*          based on 65,233,404 shares in issue as at 25 May 2022.

9. INVESTMENTS AND DERIVATIVE FINANCIAL INSTRUMENTS

                                                                                   Derivative              
                                                                                    Financial              
                                                           Quoted     Unquoted  Instruments -              
                                                      Investments  Investments            Net        Total 
                                                            £’000        £’000          £’000        £’000 
 Cost at 1 April 2021                                   1,887,379      126,577              –    2,013,956 
 Investment holdings gains at 1 April 2021                388,030       14,052         10,552      412,634 
 Valuation at 1 April 2021                              2,275,409      140,629         10,552    2,426,590 
 Movement in the year:                                                                                     
 Purchases at cost                                      1,284,504       69,066              –    1,353,570 
 Sales - proceeds                                     (1,243,999)     (15,622)          6,304  (1,253,317) 
 Transfer between levels*                                  44,424     (44,424)              –            – 
 Net movement in investment holding gains               (152,963)       22,824       (21,985)    (152,124) 
 Valuation at 31 March 2022                             2,207,375      172,473        (5,129)    2,374,719 
 Cost at 31 March 2022                                  1,952,701      136,760              –    2,089,461 
 Investment holding gains/(losses) at 31 March 2022       254,674       35,713        (5,129)      285,258 
 Valuation at 31 March 2022                             2,207,375      172,473        (5,129)    2,374,719 

*          See Note 16.

The Company received £1,253,317,000 (2021: £1,484,698,000) from investments
and derivatives sold in the year. The book cost of these was £1,278,065,000
(2021: £1,217,151,000). These investments and derivatives have been revalued
over time and until they were sold any unrealised gains/losses were included
in the fair value of the investments.

                                                                      2022      2021 
                                                                     £’000     £’000 
 Net movement in investment holding (losses)/gains in the year   (130,139)   483,612 
 Net movement in derivative holding (losses)/gains in the year    (21,985)    33,760 
 Effective interest rate amortisation                                (351)     (105) 
 (Losses)/gains on investments                                   (152,475)   517,267 

Purchase transaction costs were £1,668,000 (2021: £2,808,000). Sales
transaction costs were £1,244,000 (2021: £1,352,000). These comprise mainly
commission and stamp duty.

10. DERIVATIVE FINANCIAL INSTRUMENTS

                                                  2022      2021 
                                                 £’000     £’000 
 Fair value of OTC equity swaps (asset)            283    18,864 
 Fair value of OTC equity swaps (liability)    (5,412)   (8,312) 
                                               (5,129)    10,552 

See note 9 above for movements during the year.

11. DEBTORS

                                               2022      2021 
                                              £’000     £’000 
 Amounts due from brokers                    10,581    10,402 
 Issue of own shares awaiting settlement          –     2,577 
 Withholding taxation recoverable             2,587     2,295 
 VAT recoverable                                  –        66 
 Prepayments and accrued income               1,556     2,832 
                                             14,724    18,172 

12. CREDITORS AMOUNTS FALLING DUE WITHIN ONE YEAR

                                    2022      2021 
                                   £’000     £’000 
 Amounts due to brokers           30,131     6,840 
 Overdraft drawn*                113,597    49,896 
 Performance fee provision**           –    31,748 
 Other creditors and accruals      4,076     4,448 
                                 147,804    92,932 
* The Company’s borrowing requirements are met through the utilisation of an
overdraft facility provided by J.P. Morgan Securities LLC. The overdraft is
drawn down in U.S. dollars. Interest on the drawn overdraft is charged at the
United States Overnight Bank Funding Rate plus 45 basis points.
J.P. Morgan Securities LLC may take investments up to 140% of the value of the
overdrawn balance as collateral and has been granted a first priority security
interest or lien over the Company’s assets.
* As at 31 March 2022 no performance fees were accrued or payable (31 March
2021: £31.7 million). Of the 31 March 2021 accrual, £12.9 million
crystallised and became payable as at 30 June 2021 and £18.9 million reversed
due to underperformance, as set out in note 3. The performance fee paid
related to outperformance generated as at 30 June 2020 that was maintained to
30 June 2021.
13. SHARE CAPITAL

                                                                    Total 
                                                     Treasury      shares 
                                             Shares    shares    in issue 
                                             number    number      number 
 Issued and fully paid at 1 April 2021   64,310,255         –  64,310,255 
 New shares issued                        1,227,500         –   1,227,500 
 Shares purchased for treasury             (80,509)    80,509           – 
 At 31 March 2022                        65,457,246    80,509  65,537,755 

   

                                2022      2021 
                               £’000     £’000 
 Issued and fully paid:                        
 Ordinary Shares of 25p       16,385    16,078 

During the year ended 31 March 2022 1,227,500 shares were issued raising
£45,549,000 and 80,509 shares were repurchased into Treasury at a cost of
£2,544,000 (2021: 10,690,977 shares were issued raising £380,588,000 and no
shares were repurchased).

14. NET ASSET VALUE PER SHARE

                                 2022      2021 
 Net asset value per share   3,465.2p  3,703.0p 

The net asset value per share is based on the assets attributable to equity
shareholders of £2,268,233,000 (2021: £2,381,425,000) and on the number of
shares in issue at the year end of 65,457,246 (2021: 64,310,255).

15. RELATED PARTIES

The following are considered to be related parties:
* Frostrow Capital LLP (under the Listing Rules only)
* OrbiMed Capital LLC
* The Directors of the Company
Details of the relationship between the Company and Frostrow Capital LLP, the
Company’s AIFM, and OrbiMed Capital LLC, the Company’s Portfolio Manager,
are disclosed in the Business Review and in the Report of the Directors. Sven
Borho, who joined the Board on 7 June 2018, is a Managing Partner at OrbiMed.
Sven Borho has waived his Director’s fee of £33,573 (2021: £32,282).
Details of fees paid to OrbiMed by the Company can be found in note 3. All
material related party transactions have been disclosed in notes 3 and 4.

Three current and two former partners at OrbiMed Capital LLC have a minority
financial interest totalling 20% in Frostrow Capital LLP, the Company’s
AIFM. Details of the fees paid to Frostrow Capital LLP by the Company can be
found in note 3.

16. FINANCIAL INSTRUMENTS

Risk management policies and procedures

The Company’s financial instruments comprise securities and other
investments, derivative instruments, cash balances, loans and debtors and
creditors that arise directly from its operations.

As an investment trust, the Company invests in equities and other investments
for the long term so as to secure its investment objective. In pursuing its
investment objective, the Company is exposed to a variety of risks that could
result in a reduction in the Company’s net assets.

The main risks that the Company faces arising from its financial instruments
are:
1. market risk (including foreign currency risk, interest rate risk and other
price risk)
2. liquidity risk
3. credit risk
These risks, with the exception of liquidity risk, and the Directors’
approach to the management of them, are set out in the Strategic Report and
have not changed from the previous accounting year. The AIFM, in close
co-operation with the Board and the Portfolio Manager, co-ordinates the
Company’s risk management.

Use of derivatives

As noted in the Strategic Report, equity swaps are used within the Company’s
portfolio.

More details on swaps can be found in the Glossary.

OTC equity swaps

The Company uses OTC equity swap positions to gain access to the Indian and
Chinese markets either when it is more cost effective to gain access via swaps
or to gain exposure to thematic baskets of stocks.

Details of financed swap positions* are noted in the Portfolio.

*          See glossary.

Offsetting disclosure

Swap trades and OTC derivatives are traded under ISDA† Master Agreements.
The Company currently has such agreements in place with Goldman Sachs and JP
Morgan.

These agreements create a right of set-off that becomes enforceable only
following a specified event of default, or in other circumstances not expected
to arise in the normal course of business. As the right of set-off is not
unconditional, for financial reporting purposes, the Company does not offset
derivative assets and derivative liabilities.

†         International Swap Dealers Association Inc.

(i) Other price risk

In pursuance of the Company’s Investment Objective the Company’s
portfolio, including its derivatives, is exposed to the risk of fluctuations
in market prices and foreign exchange rates.

The Board manage these risks through the use of limits and guidelines, monthly
compliance reports from Frostrow and reports from Frostrow and OrbiMed
presented at each Board meeting.

Other price risk exposure

The Company’s gross exposure to other price risk is represented by the fair
value of the investments and the underlying exposure through the derivative
investments held at the year end as shown in the table below.

                                                 2022                               2021 
                                            Notional*                          Notional* 
                       Assets  Liabilities   exposure     Assets  Liabilities   exposure 
                        £’000        £’000      £’000      £’000        £’000      £’000 
 Investments        2,379,848            –  2,379,848  2,416,038            –  2,416,038 
 OTC equity swaps         283      (5,412)    135,018     18,864      (8,312)    145,636 
                    2,380,131      (5,412)  2,514,866  2,434,902      (8,312)  2,561,674 

*          The notional exposure is calculated in accordance with the
AIFMD requirements for calculating exposure via derivatives. See glossary.

Other price risk sensitivity

If market prices of all of the Company’s financial instruments including the
derivatives at the Statement of Financial Position date had been 25% higher or
lower (2021: 25% higher or lower) while all other variables remained constant:
the revenue return would have decreased/increased by £0.2 million (2021:
£0.2 million); the capital return would have increased by £608.4 million
(2021: £540.4 million)/decreased by £625.4 million (2021: £604.0 million);
and, the return on equity would have increased by £608.2 million (2021:
£540.1 million)/decreased by £625.2 million (2021: £603.8 million). The
calculations are based on the portfolio as at the respective Statement of
Financial Position dates and are not representative of the year as a whole.

(ii) Foreign currency risk

A significant proportion of the Company’s portfolio and derivative positions
are denominated in currencies other than sterling (the Company’s functional
currency, and the currency in which it reports its results). As a result,
movements in exchange rates can significantly affect the sterling value of
those items.

Foreign currency exposure

The fair values of the Company’s monetary assets and liabilities that are
denominated in foreign currencies are shown below.

                                                  2022                                2021 
                     Current      Current                Current      Current              
                      assets  liabilities  Investments    assets  liabilities  Investments 
                       £’000        £’000        £’000     £’000        £’000        £’000 
 U.S. dollar          64,264    (169,551)    1,821,239    72,352     (99,943)    2,034,533 
 Swiss franc           2,202            –      113,899     1,513            –       47,411 
 Japanese yen            332          114       83,225       858            –       42,203 
 Hong Kong dollar        851        (851)      190,260         –            –      179,407 
 Other                   155            –       30,803       489            –       17,642 
                      67,804    (170,288)    2,239,426    75,212     (99,943)    2,321,196 

Foreign currency sensitivity

The following table details the sensitivity of the Company’s net return for
the year and shareholders’ funds to a 10% increase and decrease in sterling
against the relevant currency (2021: 10% increase and decrease).

These percentages have been determined based on market volatility in exchange
rates over the previous 12 months. The sensitivity analysis is based on the
Company’s significant foreign currency exposures at each Statement of
Financial Position date.

                                                           2022                                     2021 
                              USD       YEN       CHF       HKD        USD       YEN       CHF       HKD 
                            £’000     £’000     £’000     £’000      £’000     £’000     £’000     £’000 
 Sterling depreciates     206,233     9,297    12,900    21,140    238,003     4,785     5,436    19,934 
 Sterling appreciates   (168,736)   (7,606)  (10,555)  (17,296)  (194,730)   (3,915)   (4,448)  (16,310) 

(iii) Interest rate risk

Interest rate changes may affect:
* the interest payable on the Company’s variable rate borrowings;
* the level of income receivable from floating and fixed rate securities and
cash at bank and on deposit;
* the fair value of investments in fixed interest securities.
Interest rate exposure

The Company’s main exposure to interest rate risks is through its overdraft
facility with J.P. Morgan Securities LLC, which is repayable on demand, and
its holding in fixed interest securities. The exposure of financial assets and
liabilities to fixed and floating interest rates, is shown below.

At 31 March 2022, the Company held 0.4% of the portfolio in securitised debt
(2021: 0.7% of the portfolio). The exposure is shown in the table below.

                                                                                                                                                                                  2022                                                                                                                                                       2021 
                             Weighted  average  period  for which  rate is  fixed  Years  Weighted  average  fixed  interest  rate  %     Fixed  rate  £’000     Floating  rate  £’000  Weighted  average  period  for which  rate is  fixed  Years  Weighted  average  fixed  interest  rate  %     Fixed  rate  £’000     Floating  rate  £’000 
 Unquoted debt investments                                                           2.9                                          2.6                  5,024                         –                                                          3.9                                          2.6                  6,945                     4,486 
 Cash                                                                                                                                                      –                    56,336                                                                                                                                –                    40,858 
 Overdraft facility                                                                                                                                        –                 (143,339)                                                                                                                                –                  (61,159) 
 Financed swap positions                                                                                                                                   –                 (140,147)                                                                                                                                –                 (135,084) 
                                                                                                                                                       5,024                 (227,150)                                                                                                                            6,945                 (150,899) 

All interest rate exposures are held in U.S. dollars.

Cash of £56.3 million (2021: £40.9 million) was held as collateral against
the financed swap positions, of which £29.7 million (2021: £11.3 million)
was offset against the overdraft position.

Interest rate sensitivity

If interest rates had been 1% higher or lower and all other variables were
held constant, the Company’s net return for the year ended 31 March 2022 and
the net assets would increase/decrease by £2.3 million (2021:
increase/decrease by £1.5 million).

(iv) Liquidity risk

This is the risk that the Company will encounter difficulty in meeting
obligations associated with financial liabilities.

Management of the risk

Liquidity risk is not considered significant as the majority of the
Company’s assets are investments in quoted securities that are readily
realisable within one week, in normal market conditions. There maybe
circumstances where market liquidity is lower than normal. Stress tests have
been performed to understand how long the portfolio would take to realise in
such situations. The Board is comfortable that in such a situation the Company
would be able to meet its liabilities as they fall due.

Liquidity exposure and maturity

Contractual maturities of the financial liability exposures as at 31 March
2022, based on the earliest date on which payment can be required, are as
follows:

                                                     2022                2021 
                                        3 to 12  3 months   3 to 12  3 months 
                                         months   or less    months   or less 
                                          £’000     £’000     £’000     £’000 
 Overdraft facility                           –   143,339         –    61,159 
 Amounts due to brokers and accruals          –    30,131         –     6,840 
 OTC equity swaps                         5,412         –     8,312         – 
                                          5,412   173,470     8,312    67,999 

£56.3 million of cash held as collateral is offset against the overdraft
facility in the Statement of Financial Position, as set out in Note 16(iii)
above.

(v) Credit risk

Credit risk is the risk of failure of a counterparty to discharge its
obligations resulting in the Company suffering a financial loss.

The carrying amounts of financial assets best represent the maximum credit
risk at the Statement of Financial Position date. The Company’s quoted
securities are held on its behalf by J.P. Morgan Securities LLC acting as the
Company’s Custodian and Prime Broker.

Certain of the Company’s assets can be held by J.P. Morgan Securities LLC as
collateral against the overdraft provided by them to the Company. As at 31
March 2022 such assets held by J.P. Morgan Securities LLC are available for
rehypothecation (see Glossary for further information). As at 31 March 2022,
assets with a total market value of £203.1 million (2021: £106.9 million)
were available to J.P. Morgan Securities LLC to be used as collateral against
the overdraft facility which equates to 140% of the overdrawn position
(calculated on a settled basis).

CREDIT RISK EXPOSURE

                                                                                       2022      2021 
                                                                                      £’000     £’000 
 Unquoted debt investments                                                            5,024    11,430 
 Derivative – OTC equity swaps                                                          283    18,864 
 Current assets:                                                                                      
 Other receivables (amounts due from brokers, dividends and interest receivable)     14,724    18,172 
 Cash                                                                                26,594    29,595 

(vi) Fair value of financial assets and financial liabilities

Financial assets and financial liabilities are either carried in the Statement
of Financial Position at their fair value (investments and derivatives) or the
Statement of Financial Position amount is a reasonable approximation of fair
value (due from brokers, dividends and interest receivable, due to brokers,
accrual, cash at bank, bank overdraft and amounts due under the loan
facility).

(vii) Hierarchy of investments

The Company has classified its financial assets designated at fair value
through profit or loss and the fair value of derivative financial instruments
using a fair value hierarchy that reflects the significance of the inputs used
in making the fair value measurements. The hierarchy has the following levels:
* Level 1 – quoted prices (unadjusted) in active markets for identical
assets or liabilities;
* Level 2 – inputs other than quoted prices included with Level 1 that are
observable for the asset or liability, either directly (i.e. as prices) or
indirectly (i.e. derived from prices); and
* Level 3 – inputs for the asset or liability that are not based on
observable market data (unobservable inputs).
 As of 31 March 2022                                        Level 1  £’000     Level 2  £’000     Level 3  £’000     Total  £’000 
 Investments held at fair value through profit or loss           2,207,375                  –            172,473        2,379,848 
 Derivatives: OTC swaps (assets)                                         –                283                  –              283 
 Derivatives: OTC swaps (liabilities)                                    –            (5,412)                  –          (5,412) 
 Financial instruments measured at fair value                    2,207,375            (5,129)            172,473        2,374,719 

As at 31 March 2022, one debt, twelve equity and a deferred consideration
investment (included in the portfolio) have been classified as level 3. All
level 3 positions have been valued in accordance with the accounting policy
set out in Note 1(b).

During 2022 four unquoted investments were transferred to Level 1 following
their initial public offerings.

 As of 31 March 2021                                       Level 1   Level 2   Level 3      Total 
                                                             £’000     £’000     £’000      £’000 
 Investments held at fair value through profit or loss   2,275,409         –   140,629  2,416,038 
 Derivatives: OTC swaps (assets)                                 –    18,864         –     18,864 
 Derivatives: OTC swaps (liabilities)                            –   (8,312)         –    (8,312) 
 Financial instruments measured at fair value            2,275,409    10,552   140,629  2,426,590 

As at 31 March 2021, three debt, eleven equity and a deferred consideration
investment have been classified as Level 3. All level 3 positions have been
valued using an independent third party pricing source or using the price of a
recent transaction.

During 2021 three unquoted investments were acquired and subsequently
transferred to Level 1 following their initial public offerings.

(viii) Capital management policies and procedures

The Company’s capital management objectives are to ensure that it will be
able to continue as a going concern and to maximise the income and capital
return to its equity shareholders through an appropriate level of gearing or
leverage.

The Board’s policy on gearing and leverage is set out in the Strategic
Report.

As at 31 March 2022, the Company had a net leverage percentage of 10.9% (2021:
7.6%).

The capital structure of the Company consists of the equity share capital,
retained earnings and other reserves as shown in the Statement of Financial
Position.

The Board, with the assistance of the AIFM and the Portfolio Manager, monitors
and reviews the broad structure of the Company’s capital on an ongoing
basis. This includes a review of:
* the planned level of gearing, which takes into account the Portfolio
Manager’s view of the market;
* the need to buy back equity shares, either for cancellation or to hold in
treasury, in light of any share price discount to net asset value per share in
accordance with the Company’s share buy-back policy;
* the need for new issues of equity shares, including issues from treasury;
and
* the extent to which revenue in excess of that which is required to be
distributed should be retained.
The Company’s objectives, policies and processes for managing capital are
unchanged from the preceding accounting year.

17. CAPITAL RESERVE

                                             Capital Reserves         
                                                Investment            
                                                   Holding            
                                         Other      Gains*      Total 
                                         £’000       £’000      £’000 
 At 31 March 2021                      966,717     575,911  1,542,628 
 Net losses on investments            (25,105)   (127,370)  (152,475) 
 Expenses charged to capital             (229)           –      (229) 
 Exchange loss on currency balances    (6,342)           –    (6,342) 
 Shares repurchased for Treasury       (2,544)           –    (2,544) 
 At 31 March 2022                      932,497     448,541  1,381,038 

*          Investment holding gains relate to the revaluation of
investments and derivatives held at the reporting date. (See note 9 for
further details).

Under the Company’s Articles of Association, sums within “capital reserves
– other” are also available for distribution.

18. RECONCILIATION OF OPERATING (LOSS)/RETURN TO NET CASH INFLOW FROM
OPERATING ACTIVITIES

                                                                                   2022       2021 
                                                                                  £’000      £’000 
 (Loss)/returns before finance charges and taxation                           (137,057)    480,129 
 Add: capital loss/(less: capital gain) before finance charges and taxation     158,285  (463,073) 
 Revenue return before finance charges and taxation                              21,228     17,056 
 Expenses charged to capital                                                        532   (48,118) 
 Decrease in other debtors                                                        1,342        934 
 (Decrease)/increase in provisions, and other creditors and accruals           (32,120)     33,302 
 Net taxation suffered on investment income                                     (3,960)    (2,138) 
 Amortisation                                                                     (351)      (105) 
 Net cash (outflow)/inflow from operating activities                           (13,329)        931 

GLOSSARY OF TERMS AND ALTERNATIVE PERFORMANCE MEASURES (‘APMS’)

ALTERNATIVE INVESTMENT FUND MANAGERS DIRECTIVE (AIFMD)

Agreed by the European Parliament and the Council of the European Union and
transported into UK legislation, the AIFMD classifies certain investment
vehicles, including investment companies, as Alternative Investment Funds
(AIFs) and requires them to appoint an Alternative Investment Fund Manager
(AIFM) and a depositary to manage and oversee the operations of the investment
vehicle. The Board of the Company retains responsibility for strategy,
operations and compliance and the Directors retain a fiduciary duty to
shareholders.

ALTERNATIVE PERFORMANCE MEASURE (‘APM’)

An APM is a numerical measure of the Company’s current, historical or future
financial performance, financial position or cash flows, other than a
financial measure defined or specified in the applicable financial framework.
In selecting these Alternative Performance Measures, the Directors considered
the key objectives and expectations of typical investors in an investment
trust such as the Company.

DISCOUNT OR PREMIUM*

A description of the difference between the share price and the net asset
value per share. The size of the discount or premium is calculated by
subtracting the share price from the net asset value per share and is usually
expressed as a percentage (%) of the net asset value per share. If the share
price is higher than the net asset value per share the result is a premium. If
the share price is lower than the net asset value per share, the shares are
trading at a discount.

EQUITY SWAPS

An equity swap is an agreement where one party (counterparty) transfers the
total return of an underlying equity position to the other party (swap holder)
in exchange for a payment of the principal, and interest for financed swaps,
at a set date. Total return includes dividend income and gains or losses from
market movements. The exposure of the holder is the market value of the
underlying equity position.

The company uses two types of equity swap:
* funded, where payment is made on acquisition. They are equivalent to holding
the underlying equity position with the exception of additional counterparty
risk and not possessing voting rights in the underlying; and,
* financed, where payment is made on maturity. Financed swaps increase
exposure by the value of the underlying equity position, with no initial
outlay and no increase in the investment portfolio’s value – there is
therefore embedded leverage within a financed swap due to the deferral of
payment to maturity.
The Company employs swaps for two purposes:
* To gain access to individual stocks in the Indian, Chinese and other
emerging markets, where the Company is not locally registered to trade or is
able to gain in a more cost efficient manner than holding the stocks directly;
and,
* To gain exposure to thematic baskets of stocks (a Basket Swap). Basket Swaps
are used to build exposure to themes, or ideas, that the Portfolio Manager
believes the Company will benefit from and where holding a Basket Swap is more
cost effective and operationally efficient than holding the underlying stocks
or individual swaps.
GEARING*

Gearing is calculated as the overdraft drawn, less net current assets
(excluding dividends), divided by Net Assets, expressed as a percentage. For
years prior to 2013, the calculation was based on borrowings as a percentage
of Net Assets.

*          Alternative Performance Measure

INTERNATIONAL SWAPS AND DERIVATIVES ASSOCIATION (‘ISDA’)

ISDA has created a standardised contract (the ISDA Master Agreement) which
sets out the basic trading terms between the counterparties to derivative
contracts.

LEVERAGE*

Leverage is defined in the AIFMD as any method by which the AIFM increases the
exposure of an AIF. In addition to the gearing limit the Company also has to
comply with the AIFMD leverage requirements. For these purposes the Board has
set a maximum leverage limit of 140% for both methods. This limit is expressed
as a % with 100% representing no leverage or gearing in the Company. There are
two methods of calculating leverage as follows:

The Gross Method is calculated as total exposure divided by Shareholders’
Funds. Total exposure is calculated as net assets, less cash and cash
equivalents, adding back cash borrowing plus derivatives converted into the
equivalent position in their underlying assets.

The Commitment Method is calculated as total exposure divided by Shareholders
Funds. In this instance total exposure is calculated as net assets, less cash
and cash equivalents, adding back cash borrowing plus derivatives converted
into the equivalent position in their underlying assets, adjusted for netting
and hedging arrangements.

See the definition of Options and Equity Swaps for more details on how
exposure through derivatives is calculated.

                                 2022                   2021          
                                £’000                  £’000          
                        Fair Value  Exposure*  Fair Value  Exposure*  
 Investments              2,379,848  2,379,848   2,416,038  2,416,038 
 OTC equity swaps           (5,129)    135,018      10,552    145,636 
                          2,374,719  2,514,866   2,426,590  2,561,674 
 Shareholders’ funds                 2,268,233              2,381,425 
 Leverage %                              10.9%                   7.6% 

*          Calculated in accordance with AIFMD requirements using the
Commitment Method

MSCI WORLD HEALTH CARE INDEX (THE COMPANY’S BENCHMARK)

The MSCI World Health Care Index is designed to capture the large and mid
capitalisation segments across 23 developed markets countries: All securities
in the index are classified as healthcare as per the Global Industry
Classification Standard (GICS). Developed Markets countries include:
Australia, Austria, Belgium, Canada, Denmark, Finland, France, Germany, Hong
Kong, Ireland, Israel, Italy, Japan, Netherlands, New Zealand, Norway,
Portugal, Singapore, Spain, Sweden, Switzerland the UK and the U.S. The net
total return of the Index is used which assumes the reinvestment of any
dividends paid by its constituents after the deduction of relevant withholding
taxes. The performance of the Index is calculated in U.S.$ terms. Because the
Company’s reporting currency is £ the prevailing U.S.$/£ exchange rate is
applied to obtain a £ based return.

NAV PER SHARE (PENCE)

The value of the Company’s assets, principally investments made in other
companies and cash being held, minus any liabilities. The NAV is also
described as ‘shareholders’ funds’ per share. The NAV is often expressed
in pence per share after being divided by the number of shares which have been
issued. The NAV per share is unlikely to be the same as the share price which
is the price at which the Company’s shares can be bought or sold by an
investor. The share price is determined by the relationship between the demand
and supply of the shares.

*          Alternative Performance Measure

NET ASSET VALUE (NAV) PER SHARE TOTAL RETURN*

The theoretical total return on shareholders’ funds per share, reflecting
the change in NAV assuming that dividends paid to shareholders were reinvested
at NAV at the time the shares were quoted ex-dividend. A way of measuring
investment management performance of investment trusts which is not affected
by movements in discounts/premiums.

                                     2022     2021 
 NAV Total Return                       p        p 
 Opening NAV                      3,703.0  2,868.9 
 (Decrease)/increase in NAV       (237.8)    834.1 
 Closing NAV                      3,465.2  3,703.0 
 % (decrease)/increase in NAV      (6.4%)    29.1% 
 Impact of reinvested dividends      0.6%     0.9% 
 NAV Total Return                  (5.8%)    30.0% 

ONGOING CHARGES*

Ongoing charges are calculated by taking the Company’s annualised ongoing
charges, excluding finance costs, taxation, performance fees and exceptional
items, and expressing them as a percentage of the average daily net asset
value of the Company over the year.

                                                                                          2022       2021 
                                                                                         £’000      £’000 
 AIFM & Portfolio Management fees (Note 3)                                              18,765     17,068 
 Other Expenses – Revenue (Note 4)                                                       1,305      1,338 
 Total Ongoing Charges                                                                  20,070     18,406 
 Performance fees paid/crystallised                                                     12,861          – 
 Total                                                                                  32,931     18,406 
 Average net assets                                                                  2,356,131  2,112,164 
 Ongoing Charges                                                                          0.9%       0.9% 
 Ongoing Charges (including performance fees paid or crystallised during the year)        1.4%       0.9% 

Rehypothecation

Rehypothecation is the practice by banks and brokers of using, for their own
purposes, assets that have been posted as collateral by clients.

SHARE PRICE TOTAL RETURN*

Return to the investor on mid-market prices assuming that all dividends paid
were reinvested.

                                           2022     2021 
 Share Price Total Return                     p        p 
 Opening share price                    3,695.0  2,920.0 
 (Decrease)/increase in share price     (420.0)    775.0 
 Closing share price                    3,275.0  3,695.0 
 % (decrease)/increase in share price   (11.4%)    26.5% 
 Impact of reinvested dividends            0.6%     0.9% 
 Share Price Total Return               (10.8%)    27.4% 

*          Alternative Performance Measure

NOTICE OF THE ANNUAL GENERAL MEETING

Notice is hereby given that the Annual General Meeting of Worldwide Healthcare
Trust PLC will be held at etc. Venues 1-3 Bonhill Street, London EC2A 4BY on
Wednesday, 6 July 2022 from 12.30 p.m. for the following purposes:

ORDINARY BUSINESS

To consider and, if thought fit, pass the following as ordinary resolutions:
1. To receive and, if thought fit, to accept the Audited Accounts and the
Report of the Directors for the year ended 31 March 2022
2. To approve the payment of a final dividend of 19.5p per ordinary share for
the year ended 31 March 2022
3. To approve the Company’s dividend policy for the year ended 31 March 2022
4. To re-elect Mrs Sarah Bates as a Director of the Company
5. To re-elect Mr Humphrey van der Klugt as a Director of the Company
6. To re-elect Mr Doug McCutcheon as a Director of the Company
7. To re-elect Mr Sven Borho as a Director of the Company
8. To re-elect Dr Bina Rawal as a Director of the Company
9. To re-appoint PricewaterhouseCoopers LLP as the Company’s Auditors and to
authorise the Audit & Risk Committee to determine their remuneration
10. To approve the Directors’ Remuneration Report for the year ended 31
March 2022
SPECIAL BUSINESS

To consider and, if thought fit, pass the following resolutions of which
resolutions 12, 13, 14 and 15 will be proposed as special resolutions:

Authority to allot shares

11. THAT in substitution for all existing authorities the Directors be and are
hereby generally and unconditionally authorised in accordance with section 551
of the Companies Act 2006 (the “Act”) to exercise all powers of the
Company to allot relevant securities (within the meaning of section 551 of the
Act) up to a maximum aggregate nominal amount of £1,630,835 (being 10% of the
issued share capital of the Company at 25 May 2022) and representing 6,523,340
shares of 25 pence each (or, if changed, the number representing 10% of the
issued share capital of the Company at the date at which this resolution is
passed), provided that this authority shall expire at the conclusion of the
Annual General Meeting of the Company to be held in 2023 or 15 months from the
date of passing this resolution, whichever is the earlier, unless previously
revoked, varied or renewed, by the Company in General Meeting and provided
that the Company shall be entitled to make, prior to the expiry of such
authority, an offer or agreement which would or might require relevant
securities to be allotted after such expiry and the Directors may allot
relevant securities pursuant to such offer or agreement as if the authority
conferred hereby had not expired.

Disapplication of pre-emption rights

12. THAT in substitution for all existing powers (and in addition to any power
conferred on them by resolution 13 set out in the notice convening the Annual
General Meeting at which this resolution is proposed (“Notice of Annual
General Meeting”)) the Directors be and are hereby generally empowered
pursuant to Section 570 of the Companies Act 2006 (the “Act”) to allot
equity securities (within the meaning of Section 560 of the Act) for cash
pursuant to the authority conferred on them by resolution 11 set out in the
Notice of Annual General Meeting or otherwise as if Section 561(1) of the Act
did not apply to any such allotment:
1. pursuant to an offer of equity securities open for acceptance for a period
fixed by the Directors where the equity securities respectively attributable
to the interests of holders of shares of 25p each in the capital of the
Company (“Shares”) are proportionate (as nearly as may be) to the
respective numbers of Shares held by them but subject to such exclusions or
other arrangements in connection with the issue as the Directors may consider
necessary, appropriate or expedient to deal with equity securities
representing fractional entitlements or to deal with legal or practical
problems arising in any overseas territory, the requirements of any regulatory
body or stock exchange, or any other matter whatsoever;
2. provided that (otherwise than pursuant to sub-paragraph (a) above) this
power shall be limited to the allotment of equity securities up to an
aggregate nominal value of £1,630,835, being 10% of the issued share capital
of the Company as at 25 May 2022 and representing 6,523,340 Shares or, if
changed, the number representing 10% of the issued share capital of the
Company at the date of the meeting at which this resolution is passed, and
provided further that (i) the number of equity securities to which this power
applies shall be reduced from time to time by the number of treasury shares
which are sold pursuant to any power conferred on the Directors by resolution
13 set out in the Notice of Annual General Meeting and (ii) no allotment of
equity securities shall be made under this power which would result in Shares
being issued at a price which is less than the net asset value per Share as at
the latest practicable date before such allotment of equity securities as
determined by the Directors in their reasonable discretion; and
and such power shall expire at the conclusion of the next Annual General
Meeting of the Company after the passing of this resolution or 15 months from
the date of passing this resolution, whichever is earlier, unless previously
revoked, varied or renewed by the Company in General Meeting and provided that
the Company shall be entitled to make, prior to the expiry of such authority,
an offer or agreement which would or might otherwise require equity securities
to be allotted after such expiry and the Directors may allot equity securities
pursuant to such offer or agreement as if the power conferred hereby had not
expired.

13. THAT in substitution for all existing powers (and in addition to any power
conferred on them by resolution 12 set out in the Notice of Annual General
Meeting) the Directors be and are hereby generally empowered pursuant to
Section 570 of the Companies Act 2006 (the “Act”) to sell relevant shares
(within the meaning of Section 560 of the Act) if, immediately before the
sale, such shares are held by the Company as treasury shares (as defined in
Section 724 of the Act (“treasury shares”)), for cash as if Section 561(1)
of the Act did not apply to any such sale provided that:

(a)    this power shall be limited to the sale of relevant shares having an
aggregate nominal value of £1,630,835 being 10% of the issued share capital
of the Company as at 25 May 2022 and representing 1,630,835 Shares or, if
changed, the number representing 10% of the issued share capital of the
Company at the date of the meeting at which this resolution is passed, and
provided further that the number of relevant shares to which power applies
shall be reduced from time to time by the number of Shares which are allotted
for cash as if Section 561(1) of the Act did not apply pursuant to the power
conferred on the Directors by resolution 12 set out in the Notice of Annual
General Meeting, and such power shall expire at the conclusion of the next
Annual General Meeting of the Company after the passing of this resolution or
15 months from the date of passing this resolution, whichever is earlier,
unless previously revoked, varied or renewed by the Company in General Meeting
and provided that the Company shall be entitled to make, prior to the expiry
of such authority, an offer or agreement which would or might otherwise
require treasury shares to be sold after such expiry and the Directors may
sell treasury shares pursuant to such offer or agreement as if the power
conferred hereby had not expired.

Authority to repurchase ordinary shares

14. THAT the Company be and is hereby generally and unconditionally authorised
in accordance with section 701 of the Companies Act 2006 (the “Act”) to
make one or more market purchases (within the meaning of section 693(4) of the
Act) of ordinary shares of 25 pence each in the capital of the Company
(“Shares”) (either for retention as treasury shares for future reissue,
resale, transfer or cancellation), provided that:
1. the maximum aggregate number of Shares authorised to be purchased shall be
that number of shares which is equal to 14.99% of the issued share capital of
the Company as at the date of the passing of this resolution;
2. the minimum price (exclusive of expenses) which may be paid for a Share is
25 pence;
3. the maximum price (exclusive of expenses) which may be paid for a Share is
an amount equal to the greater of (i) 105% of the average of the middle market
quotations for a Share as derived from the Daily Official List of the London
Stock Exchange for the five business days immediately preceding the day on
which that Share is purchased and (ii) the higher of the price of the last
independent trade and the highest then current independent bid on the London
Stock Exchange as stipulated in Article 5(1) of Regulation No. 2233/2003 of
the European Commission (Commission Regulation of 22 December 2003
implementing the Market Abuse Directive as regards exemptions for buy-back
programmes and stabilisation of financial instruments);
4. the authority hereby conferred shall expire at the conclusion of the Annual
General Meeting of the Company to be held in 2023 or, if earlier, on the
expiry of 15 months from the date of the passing of this resolution unless
such authority is renewed prior to such time; and
5. the Company may make a contract to purchase Shares under this authority
before the expiry of such authority which will or may be executed wholly or
partly after the expiration of such authority, and may make a purchase of
Shares in pursuance of any such contract.
General meetings

15. THAT the Directors be authorised to call general meetings (other than the
Annual General Meeting of the Company) on not less than 14 clear days’
notice, such authority to expire on the conclusion of the next Annual General
Meeting of the Company, or, if earlier, on the expiry 15 months from the date
of the passing of the resolution.

 By order of the Board  Registered Office:  
                        One Wood Street     
 Frostrow Capital LLP   London EC2V 7WS     
 Company Secretary                          
 26 May 2022                                

NOTES
1. Members are entitled to appoint a proxy to exercise all or any of their
rights to attend and to speak and vote on their behalf at the meeting. A
shareholder may appoint more than one proxy in relation to the meeting
provided that each proxy is appointed to exercise the rights attached to a
different share or shares held by that shareholder. A proxy need not be a
shareholder of the Company.
2. A vote withheld is not a vote in law, which means that the vote will not be
counted in the calculation of votes for or against the resolutions. If no
voting indication is given, a proxy may vote or abstain from voting at his/her
discretion. A proxy may vote (or abstain from voting) as he or she thinks fit
in relation to any other matter which is put before the meeting.
3. This year, hard copy forms of proxy have not been included with this
notice. Members can vote by: logging onto www.signalshares.com and following
instructions; requesting a hard copy form of proxy directly from the
registrars, Link Group at enquiries@linkgroup.co.uk or in the case of CREST
members, utilising the CREST electronic proxy appointment service in
accordance with the procedures set out below. To be valid any proxy form or
other instrument appointing a proxy must be completed and signed and received
by post or (during normal business hours only) by hand at Link Group, PXS1, 29
Wellington Street, 10th Floor, Central Square, Leeds LS1 4DL no later than
1.00 p.m. on Monday, 4 July 2022.
4. In the case of a member which is a company, the instrument appointing a
proxy must be executed under its seal or signed on its behalf by a duly
authorised officer or attorney or other person authorised to sign. Any power
of attorney or other authority under which the instrument is signed (or a
certified copy of it) must be included with the instrument.
5. The return of a completed proxy form, other such instrument or any CREST
Proxy Instruction (as described below) will not prevent a shareholder
attending the meeting and voting in person if he/she wishes to do so.
6. Any person to whom this notice is sent who is a person nominated under
section 146 of the Companies Act 2006 to enjoy information rights (a
“Nominated Person”) may, under an agreement between him/her and the
shareholder by whom he/she was nominated, have a right to be appointed (or
have someone else appointed) as a proxy for the meeting. If a Nominated Person
has no such proxy appointment right or does not wish to exercise it, he/she
may, under any such agreement, have a right to give instructions to the
shareholder as to the exercise of voting rights.
7. The statement of the rights of shareholders in relation to the appointment
of proxies in paragraphs 1 and 3 above does not apply to Nominated Persons.
The rights described in these paragraphs can only be exercised by shareholders
of the Company.
8. Pursuant to regulation 41 of the Uncertificated Securities Regulations
2001, only shareholders registered on the register of members of the Company
(the “Register of Members”) at the close of business on Monday, 4 July
2022 (or, in the event of any adjournment, on the date which is two days
before the time of the adjourned meeting) will be entitled to attend and vote
or be represented at the meeting in respect of shares registered in their name
at that time. Changes to the Register of Members after that time will be
disregarded in determining the rights of any person to attend and vote at the
meeting.
9. As at 25 May 2022 (being the last business day prior to the publication of
this notice) the Company’s issued share capital consists of 65,537,755
ordinary shares, carrying one vote each. The Company holds 304,351 shares in
treasury. Therefore, the total voting rights in the Company as at 25 May 2022
are 65,233,404.
10. CREST members who wish to appoint a proxy or proxies through the CREST
electronic proxy appointment service may do so by using the procedures
described in the CREST Manual. CREST Personal Members or other CREST sponsored
members, and those CREST members who have appointed a service provider(s),
should refer to their CREST sponsor or voting service provider(s), who will be
able to take the appropriate action on their behalf.
11. In order for a proxy appointment or instruction made using the CREST
service to be valid, the appropriate CREST message (a “CREST Proxy
Instruction”) must be properly authenticated in accordance with the
specifications of Euroclear UK and Ireland Limited (“CRESTCo”), and must
contain the information required for such instruction, as described in the
CREST Manual. The message, regardless of whether it constitutes the
appointment of a proxy or is an amendment to the instruction given to a
previously appointed proxy must, in order to be valid, be transmitted so as to
be received by the issuer’s agent (ID RA10) no later than 48 hours before
the time appointed for holding the meeting. For this purpose, the time of
receipt will be taken to be the time (as determined by the timestamp applied
to the message by the CREST Application Host) from which the issuer’s agent
is able to retrieve the message by enquiry to CREST in the manner prescribed
by CREST. After this time any change of instructions to proxies appointed
through CREST should be communicated to the appointee through other means.
12. CREST members and, where applicable, their CREST sponsors, or voting
service providers should note that CRESTCo does not make available special
procedures in CREST for any particular message. Normal system timings and
limitations will, therefore, apply in relation to the input of CREST Proxy
Instructions. It is the responsibility of the CREST member concerned to take
(or, if the CREST member is a CREST personal member, or sponsored member, or
has appointed a voting service provider, to procure that his CREST sponsor or
voting service provider(s) take(s)) such action as shall be necessary to
ensure that a message is transmitted by means of the CREST system by any
particular time. In this connection, CREST members and, where applicable,
their CREST sponsors or voting system providers are referred, in particular,
to those sections of the CREST Manual concerning practical limitations of the
CREST system and timings.
13. The Company may treat as invalid a CREST Proxy Instruction in the
circumstances set out in Regulation 35(5)(a) of the Uncertificated Securities
Regulations-2001.
14. In the case of joint holders, where more than one of the joint holders
purports to appoint a proxy, only the appointment submitted by the most senior
holder will be accepted. Seniority is determined by the order in which the
names of the joint holders appear in the Register of Members in respect of the
joint holding (the first named being the most senior).
15. Members who wish to change their proxy instructions should submit a new
proxy appointment using the methods set out above. Note that the cut-off time
for receipt of proxy appointments (see above) also applies in relation to
amended instructions; any amended proxy appointment received after the
relevant cut-off time will be disregarded.
16. Members who have appointed a proxy using the hard-copy proxy form and who
wish to change the instructions using another hard-copy form, should contact
Link Group on 0371 600 0300 or +44 371 600 0300. Calls are charged at the
standard geographic rate and will vary by provider. Calls outside the United
Kingdom are charged at the applicable international rate. Lines are open 09.00
to 17.30 Monday to Friday excluding public holidays in England and Wales.
17. If a member submits more than one valid proxy appointment, the appointment
received last before the latest time for the receipt of proxies will
take-precedence.
18. In order to revoke a proxy instruction, members will need to inform the
Company. Members should send a signed hard copy notice clearly stating their
intention to revoke a proxy appointment to Link Group, PXS1, 29 Wellington
Street, 10th Floor, Central Square, Leeds LS1 4DL. In the case of a member
which is a company, the revocation notice must be executed under its common
seal or signed on its behalf by an officer of the company or an attorney for
the company. Any power of attorney or any other authority under which the
revocation notice is signed (or a duly certified copy of such power of
attorney) must be included with the revocation notice. If a member attempts to
revoke their proxy appointment but the revocation is received after the time
for receipt of proxy appointments (see above) then, subject to paragraph 4,
the proxy appointment will remain valid.
How To Vote

If you hold your shares directly you can:
* Log on to https://www.signalshares.com and follow the instructions; or
* Request a hard copy form of proxy from the Company’s registrars, Link
Group, by emailing enquiries@linkgroup.co.uk or by calling +44 (0)371 664 0321
and returning the completed form to Link Group, PXS1, 10th Floor, Central
Square,  29 Wellington Street, Leeds LS1 4DL, no later than 12.30 pm on 4
July 2022.
If you hold your shares via an investment platform (e.g. Hargreaves Lansdown)
or a nominee, you should contact them to enquire about arrangements to vote.

EXPLANATORY NOTES TO THE RESOLUTIONS

Resolution 1 – To receive the Annual Report and Accounts

The Annual Report and Accounts for the year ended 31 March 2022 will be
presented to the Annual General Meeting (AGM). These accounts accompany this
Notice of Meeting.

Resolution 2 – To approve a Final Dividend

The rationale for the payment of a final dividend is set out in the
Chairman’s Statement and the Report of the Directors.

Resolution 3 – Approval of the Company’s Dividend Policy

Resolution 3 seeks shareholder approval of the Company’s dividend policy.

Resolutions 4 to 8 – Re-election of Directors

Resolutions 4 to 8 deal with the re-election of each Director.

The Board has confirmed, following a performance review, that the Directors
standing for re-election and election continue to perform effectively.

Resolution 9 – Re-appointment of Auditors and the determination of their
remuneration

Resolution 9 relates to the re-appointment of PricewaterhouseCoopers LLP as
the Company’s independent Auditors to hold office until the next AGM of the
Company and also authorises the Audit & Risk Committee to set their
remuneration.

Resolutions 10 – Remuneration Report

The Directors’ Remuneration Report is set out in full in the annual report.

Resolutions 11, 12 and 13 – Issue of Shares

Ordinary Resolution 11 in the Notice of AGM will renew the authority to allot
the unissued share capital up to an aggregate nominal amount of £1,630,835
(equivalent to 6,523,340 shares, or 10% of the Company’s existing issued
share capital on 25 May 2022, being the nearest practicable date prior to the
signing of this Report (or if changed, the number representing 10% of the
issued share capital of the Company at the date at which the resolution is
passed). Such authority will expire on the date of the next AGM or after a
period of 15 months from the date of the passing of the resolution, whichever
is earlier. This means that the authority will have to be renewed at the next
AGM.

When shares are to be allotted for cash, Section 551 of the Companies Act 2006
(the “Act”) provides that existing shareholders have pre-emption rights
and that the new shares must be offered first to such shareholders in
proportion to their existing holding of shares. However, shareholders can, by
special resolution, authorise the Directors to allot shares otherwise than by
a pro rata issue to existing shareholders. Special Resolution 12 will, if
passed, give the Directors power to allot for cash equity securities up to 10%
of the Company’s existing share capital on 25 May 2022 (or if changed, the
number representing 10% of the issued share capital of the Company at the date
at which the resolution is passed), as if Section 551 of the Act does not
apply. This is the same nominal amount of share capital which the Directors
are seeking the authority to allot pursuant to Resolution 11. This authority
will also expire on the date of the next Annual General Meeting or after a
period of 15 months, whichever is earlier. This authority will not be used in
connection with a rights issue by the Company.

Under the Companies (Acquisition of Own Shares) (Treasury Shares) Regulations
2003 (as amended) (the “Treasury Share Regulations”) the Company is
permitted to buy-back and hold shares in treasury and then sell them at a
later date for cash, rather than cancelling them. The Treasury Share
Regulations require such sale to be on a pre-emptive, pro rata, basis to
existing shareholders unless shareholders agree by special resolution to
disapply such pre-emption rights. Accordingly, in addition to giving the
Directors power to allot unissued share capital on a non pre-emptive basis
pursuant to Resolution 12, Resolution 13, if passed, will give the Directors
authority to sell shares held in treasury on a non pre-emptive basis. No
dividends may be paid on any shares held in treasury and no voting rights will
attach to such shares. The benefit of the ability to hold treasury shares is
that such shares may be resold. This should give the Company greater
flexibility in managing its share capital, and improve liquidity in its
shares. It is the intention of the Board that any re-sale of treasury shares
would only take place at a premium to the cum income net asset value per
share. It is also the intention of the Board that sales from treasury would
only take place when the Board believes that to do so would assist in the
provision of liquidity to the market. The number of treasury shares which may
be sold pursuant to this authority is limited to 10% of the Company’s
existing share capital on 25 May 2022 (or if changed, the number representing
10% of the issued share capital of the Company at the date at which the
resolution is passed) (reduced by any equity securities allotted for cash on a
non-pro rata basis pursuant to Resolution 12, as described above). This
authority will also expire on the date of the next Annual General Meeting or
after a period of 15 months, whichever is earlier.

The Directors intend to use the authority given by Resolutions 11, 12 and 13
to allot shares and disapply pre-emption rights only in circumstances where
this will be clearly beneficial to shareholders as a whole. The issue proceeds
would be available for investment in line with the Company’s investment
policy. No issue of shares will be made which would effectively alter the
control of the Company without the prior approval of shareholders in general
meeting.

New Shares will only be issued at a premium to the Company’s cum income net
asset value per share at the time of issue.

Resolution 14 – Share Repurchases

The Directors wish to renew the authority given by shareholders at the
previous AGM. The principal aim of a share buy-back facility is to enhance
shareholder value by acquiring shares at a discount to net asset value, as and
when the Directors consider this to be appropriate. The purchase of Shares,
when they are trading at a discount to net asset value per share should result
in an increase in the net asset value per share for the remaining
shareholders. This authority, if conferred, will only be exercised if to do so
would result in an increase in the net asset value per share for the remaining
shareholders and if it is in the best interests of shareholders generally. Any
purchase of shares will be made within guidelines established from time to
time by the Board. It is proposed to seek shareholder authority to renew this
facility for another year at the AGM.

Under the current Listing Rules, the maximum price that may be paid on the
exercise of this authority must not exceed the higher of (i) 105% of the
average of the middle market quotations for the shares over the five business
days immediately preceding the date of purchase and (ii) the higher of the
last independent trade and the highest current independent bid on the trading
venue where the purchase is carried out. The minimum price which may be paid
is 25p per Share. Existing shares which are purchased under this authority
will either be cancelled or held as Treasury Shares.

Special Resolution 14 in the Notice of AGM will renew the authority to
purchase in the market a maximum of 14.99% of Ordinary Shares in issue as at
the date of the passing of the resolution. Such authority will expire on the
date of the next AGM or after a period of 15 months from the date of passing
of the resolution, whichever is earlier. This means in effect that the
authority will have to be renewed at the next AGM or earlier if the authority
has been exhausted.

Resolution 15 – General Meetings

Special Resolution 15 seeks shareholder approval for the Company to hold
General Meetings (other than the AGM) at 14 clear days’ notice. The Board
confirms that the shorter notice period would only be used where it was
merited by the purpose of the meeting.

Recommendation

The Board considers that the resolutions relating to the above items are in
the best interests of shareholders as a whole. Accordingly, the Board
unanimously recommends to the shareholders that they vote in favour of the
above resolutions to be proposed at the forthcoming AGM as the Directors
intend to do in respect of their own beneficial holdings totalling 53,881
shares.

REGULATORY DISCLOSURES (UNAUDITED)

ALTERNATIVE INVESTMENT FUND MANAGERS DIRECTIVE (AIFMD) DISCLOSURES

INVESTMENT OBJECTIVE AND LEVERAGE

A description of the investment strategy and objectives of the Company, the
types of assets in which the Company may invest, the techniques it may employ,
any applicable investment restrictions, the circumstances in which it may use
leverage, the types and sources of leverage permitted and the associated
risks, any restrictions on the use of leverage and the maximum level of
leverage which the AIFM and Portfolio Manager are entitled to employ on behalf
of the Company and the procedures by which the Company may change its
investment strategy and/or the investment policy can be found in the Strategic
Report under the heading “Investment Strategy”.

The table below sets out the current maximum permitted limit and actual level
of leverages for the Company: as a percentage of net assets

                                  Gross  Commitment 
                                 Method      Method 
 Maximum level of leverage       140.0%      140.0% 
 Actual level at 31 March 2022   113.4%      110.9% 

REMUNERATION OF AIFM STAFF

Following completion of an assessment of the application of the
proportionality principle to the FCA’s AIFM Remuneration Code, the AIFM has
disapplied the pay-out process rules with respect to it and any of its
delegates. This is because the AIFM considers that it carries out non--complex
activities and is operating on a small scale.

Further disclosures required under the AIFM Rules can be found within the
Investor Disclosure Document on the Company’s website: www.worldwidewh.com.

SECURITY FINANCING TRANSACTIONS DISCLOSURES

As defined in Article 3 of Regulation (EU) 2015/2365, securities financing
transactions (SFT) include repurchase transactions, securities or commodities
lending and securities or commodities borrowing, buy-sell back transactions or
sell-buy back transactions and margin lending transactions. Whilst the Company
does not engage in such SFT’s, it does engage in Total Return Swaps (TRS)
therefore, in accordance with Article 13 of the Regulation, the Company’s
involvement in and exposure to Total Return Swaps for the accounting year
ended 31 March 2022 are detailed below.

GLOBAL DATA

Amount of assets engaged in TRS

The following table represents the total value of assets engaged in TRS:

          £’000  % of AUM 
 TRS    (5,129)     (0.2) 

CONCENTRATION DATA

Counterparties

The following table provides details of the counterparties and their country
of incorporation (based on gross volume of outstanding transactions with
exposure on a gross basis) in respect of TRS as at the balance sheet date:

                    Country of           
                 Incorporation     £’000 
 Goldman Sachs          U.S.A.    99,898 
 JPMorgan               U.S.A.    35,120 

AGGREGATE TRANSACTION DATA

Type, quality, maturity, tenor and currency of collateral

No collateral was received by the Company in respect of TRS during the year to
31 March 2022. The collateral provided by the Company to the above
counterparties is set out below.

 Type  Currency  Maturity         Quality  £’000     
 Cash  USD       less than 1 day  n/a      56,336    

Maturity tenor of TRS

The following table provides an analysis of the maturity tenor of open TRS
positions (with exposure on a gross basis) as at the balance sheet date:

                       TRS 
                     Value 
 Maturity            £’000 
 1 to 3 months           – 
 3 to 12 months    135,018 

Settlement and clearing

OTC derivative transactions (including TRS) are entered into by the Company
under an International Swaps and Derivatives Associations, Inc. Master
Agreement (“ISDA Master Agreement”). An ISDA Master Agreement is a
bilateral agreement between the Company and a counterparty that governs OTC
derivative transactions (including TRS) entered into by the parties. All OTC
derivative transactions entered under an ISDA Master Agreement are netted
together for collateral purposes, therefore any collateral disclosures
provided are in respect of all OTC derivative transactions entered into by the
Company under the ISDA Master agreement, not just total return swaps.

Safekeeping of collateral

There was no non-cash collateral provided by the Company in respect of OTC
derivatives (including TRS) with the counterparties noted above as at the
statement of financial position date.

Return and cost

All returns from TRS transactions will accrue to the Company and are not
subject to any returns sharing arrangements with the Company’s AIFM,
Portfolio Manager or any other third parties. Returns from those instruments
are disclosed in Note 9 to the Company’s financial statements.

Frostrow Capital LLP,

Company Secretary

26 May 2022

ANNOUNCEMENT ENDS



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