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REG - AstraZeneca PLC - Half Yearly Report <Origin Href="QuoteRef">AZN.L</Origin> - Part 2

- Part 2: For the preceding part double click  ID:nRSd5111Ua 

movements also impacted the performance. Market share was maintained
in the second quarter however, with a 1% point growth in new-to-brand share since the start of the year. In Europe, Product
Sales declined by 7% to $469m, reflecting prevailing competitive trends. 
 
Crestor consolidated its position as the leading statin in Japan, growing its sales by 6% in the half. Emerging Markets
delivered sales growth of 5% at $352m, including 21% in China. 
 
Oncology 
 
Iressa 
 
H1 Product Sales declined by 3% to $273m, primarily a function of the competitive environment in Europe where sales were
down by 5%, and in Japan down by 14%. The latter territory saw a material swing in performance from quarter to quarter,
with year-on-year growth of 9% in Q2. 
 
Emerging Markets grew by 3% with Product Sales of $139m, with particular growth in China, up 5% and Russia, up 23%. 
 
Lynparza 
 
Product Sales reached $30m following the launch in the US at the end of 2014. Growth has been driven by the pool of
eligible patients awaiting treatment as well as patients newly-tested for BRCA mutation. Over 1,000 patients have already
been treated with Lynparza in the US for germline BRCA-advanced ovarian cancer with three or more lines of chemotherapy. 
 
Zoladex 
 
Product Sales in the half were up 9% to $409m. Notable performances included growth of 36% in China where Product Sales
reached $60m. 
 
Faslodex 
 
Product Sales for the half were up 5% to $333m. A 1% rise in European sales to $101m was complemented by 2% growth in the
US where Product Sales reached $165m. 
 
The notable performance was in Emerging Markets, where sales of $42m represented a growth rate of 32%, an encouraging
result alongside the approval of 500mg Faslodex in China in May 2015. 
 
ING 
 
Nexium 
 
Overall H1 Product Sales fell 27% to $1,291m, with Q2 sales similarly down 27% at $647m. The decline was particularly felt
in the US, where sales in the half fell 49% to $479m, reflecting the loss of exclusivity in February 2015 which directly
impacted both pricing and volumes. In Q2 this resulted in an increase to the estimate for pipeline inventory returns,
although the value of the level of business and volume maintained remains at a high level. Sales in Europe fell 10% in the
half to $143m. 
 
Product Sales in markets outside the US delivered a positive result, with H1 Latin American sales up 17%, Japan sales up
16% and China sales up 3%. Emerging Markets represent a key opportunity for Nexium, with the brand's sales totalling $397m
in the half. 
 
Seroquel XR 
 
Product Sales declined by 7% in the half to $526m, with similar falls in each quarter. In the US H1 sales were up 2% to
$353m where the performance was mainly driven by a higher underlying net price. 
 
The majority of the remainder of the brand's sales are in Europe, where a H1 sales decline of 25% to $113m was driven
primarily by competition from generic products. 
 
Synagis 
 
Product Sales fell 28% in the half to $270m, reflecting the 38% decline in the US where the majority of sales are made. A
significant factor was lower demand related to the American Academy of Pediatrics Committee on Infectious Disease
guidelines issued in mid-2014. These further restricted patients eligible for preventative therapy with Synagis. While
these guidelines were inconsistent with the approved label, demand was significantly impacted; this is anticipated to
continue in the second half. Product Sales in Europe fell 6% to $110m. 
 
Regional Product Sales 
 
________________________________________________________________________________ 
 
                                                                                                                                                                                                                        H1 2015                          Q2 2015                  
                                                                                                                                                                                                                                               % Change                 % Change               
                                                                                                                                                                                                                        $m                     CER       Actual         $m        CER  Actual          
                                                                                                                                                                                                     US                 4,525                  (9)       (9)            2,356     (3)  (3)             
                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                     Europe             2,601                  (5)       (20)           1,261     (5)  (23)            
                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                     Established ROW1   1,491                  (2)       (15)           785       -    (14)            
                                                                                                                                                                                                                        Japan                  977       2        (12)            522  6       (10)      
                                                                                                                                                                                                                        Canada                 273       6        (5)             138  5       (6)       
                                                                                                                                                                                                                        Other Established ROW  241       (23)     (33)            125  (22)    (34)      
                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                     Emerging Markets2  2,967                  14        2              1,434     9    (2)             
                                                                                                                                                                                                                        China                  1,309     19       18              583  10      11        
                                                                                                                                                                                                                        Ex.China               1,658     10       (7)             851  8       (10)      
                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                     Total              11,584                 (2)       (10)           5,836     (1)  (10)            
 1 Established ROW comprises Japan, Canada, Australia and New Zealand.2 Emerging Markets comprises all remaining Rest of World markets, including Brazil, China, India, Mexico, Russia, and Turkey.                     
                                                                                                                                                                                                     
                                                                                                                                                                                                                                                                                                           
 
 
US 
 
Product Sales in the half were down 9% to $4,525m, with an encouraging trend in sales illustrated by only a 3% fall in the
second quarter. Excluding the impact of the change in accounting related to the Branded Pharmaceutical Fee, Product Sales
in the quarter were down 1% versus the comparative period. 
 
The headline decline in sales however reflected the loss of Nexium patent exclusivity, competition facing Crestor from
therapeutic substitution by generic statins, the adverse impact of the Synagis guideline changes and the aforementioned
change in accounting related to the Branded Pharmaceutical Fee. Onglyza sales also declined in the second quarter due to
ongoing competition in the diabetes market. 
 
These declines were partly offset by growth in Brilinta, Bydureon, Farxiga, Lynparza and the inclusion of Tudorza and
Daliresp. Brilinta growth was driven by strong consecutive quarters of growth in total and new-to-brand prescription market
share gains. Bydureon continues to benefit from the launch of the Bydureon Pen as well as growth in demand in the overall
GLP-1 class. A strong acceleration in Farxiga sales reflected continued growth in demand underpinned by additional
promotional activity. With Lynparza exceeding the 1,000 patient milestone, it was encouraging to see the early benefit to
patients from a pipeline due to launch a number of important medicines in the US in the near term. 
 
Europe 
 
Product Sales in the half were down 5% to $2,601m. Strong growth from Forxiga and Onglyza was more than offset by continued
generic competition facing Crestor and Seroquel XR. An 8% decline in Symbicort sales reflected adverse pricing movements
driven by competition from analogues in key markets. 
 
Established ROW 
 
Product Sales were down 2% in the first half to $1,491m. Following a decline in the first quarter, Japan Q2 sales increased
by 6%, reflecting the passing of the anniversary of the mandated April 2014 biennial price cut. 
 
Nexium and Crestor continue to grow strongly in Japan, growing by 16% and 6% in the half, respectively. Crestor's growth
reflected a continued increase in the usage of the 5mg dosage. 
 
Canada Product Sales grew by 6% to $273m in the half, driven by the performances of Onglyza and Symbicort. 
 
Emerging Markets 
 
The Company continues to focus on delivering innovative medicines by accelerating investment in its Emerging Markets'
capabilities, with a focus on China and other leading markets, such as Russia and Brazil. 
 
Product Sales were up 14% to $2,967m in the half with growth across the region. China sales in the half increased by 19% to
$1,309m, more in line with recent trends, with the Company's medicines for respiratory, cardiovascular and diabetes
diseases delivering particularly strong results. Russia sales were up 30% to $116m, while Brazil sales were up 15% to
$206m. 
 
Q2 Product Sales were up 9% to $1,434m. China sales were up 10% to $583m, with slower growth after a 28% growth in Product
Sales in the first quarter. 
 
Financial Performance 
 
________________________________________________________________________________ 
 
 H1 2015                    Reported  Restructuring  IntangibleAmortisation & Impairments  Diabetes Alliance  Other1  Core     % Change  
 H1 2015                    H1 20142  CER            Actual                                
 Product Sales              11,584    -              -                                     -                  -       11,584   12,870    (2)   (10)  
 Externalisation Revenue    780       -              -                                     -                  -       780      352       124   122   
 Total Revenue              12,364    -              -                                     -                  -       12,364   13,222    1     (6)   
                                                                                                                                                     
 Cost of Sales              (2,336)   101            317                                   -                  -       (1,918)  (2,349)   (7)   (18)  
                                                                                                                                                     
 Gross Profit               10,028    101            317                                   -                  -       10,446   10,873    3     (4)   
 Gross Margin3              79.8%                                                                                     83.4%    81.7%     +1.0  +1.7  
                                                                                                                                                     
 Distribution               (161)     -              -                                     -                  -       (161)    (149)     23    8     
 % Total Revenue            1.3%                                                                                      1.3%     1.1%      -0.2  -0.2  
                                                                                                                                                     
 R&D                        (2,822)   124            62                                    -                  -       (2,636)  (2,306)   24    14    
 % Total Revenue            22.8%                                                                                     21.3%    17.4%     -3.8  -3.9  
                                                                                                                                                     
 SG&A                       (5,765)   223            444                                   216                298     (4,584)  (4,777)   4     (4)   
 % Total Revenue            46.6%                                                                                     37.1%    36.1%     -0.9  -1.0  
                                                                                                                                                     
 Other Operating Income     576       -              135                                   -                  (158)   553      342       77    62    
 % Total Revenue            4.7%                                                                                      4.5%     2.6%      +1.9  +1.9  
                                                                                                                                                     
 Operating Profit           1,856     448            958                                   216                140     3,618    3,983     (4)   (9)   
 % Total Revenue            15.0%                                                                                     29.3%    30.1%     -1.5  -0.8  
                                                                                                                                                     
 Net FinanceExpense         (513)     -              -                                     204                59      (250)    (267)                 
 Joint Ventures             (7)       -              -                                     -                  -       (7)      -                     
                                                                                                                                                     
 Profit Before Tax          1,336     448            958                                   420                199     3,361    3,716     (3)   (10)  
 Taxation                   (88)      (94)           (193)                                 (95)               (2)     (472)    (600)                 
 Tax Rate                   6.6%                                                                                      14.0%    16.1%                 
 Profit After Tax           1,248     354            765                                   325                197     2,889    3,116     -     (7)   
                                                                                                                                                     
 Non-controlling Interests  (1)       -              -                                     -                  -       (1)      (3)                   
 Net Profit                 1,247     354            765                                   325                197     2,888    3,113     -     (7)   
                                                                                                                                                     
 Weighted Average Shares    1,263     1,263          1,263                                 1,263              1,263   1,263    1,261                 
                                                                                                                                                     
 Earnings Per Share         0.99      0.28           0.60                                  0.26               0.16    2.29     2.47      -     (7)   
 
 
 1 Other adjustments include provision charges and settlement income related to certain legal matters (see Note 5) and fair value adjustments to contingent consideration liabilities arising on business combinations (see Note 4).  
 2 2014 comparatives have been restated to reflect the reclassification of Externalisation Revenue from Other Operating Income.                                                                                                       
 3 Gross Margin reflects Gross Profit derived from Product Sales, divided by Product Sales.                                                                                                                                           
 
 
 Q2 2015                    Reported  Restructuring  IntangibleAmortisation & Impairments  Diabetes Alliance  Other1  Core     % Change  
 Q2 2015                    Q2 20142  CER            Actual                                
 Product Sales              5,836     -              -                                     -                  -       5,836    6,454     (1)   (10)  
 Externalisation Revenue    471       -              -                                     -                  -       471      308       54    53    
 Total Revenue              6,307     -              -                                     -                  -       6,307    6,762     2     (7)   
                                                                                                                                                     
 Cost of Sales              (1,067)   58             44                                    -                  -       (965)    (1,156)   (7)   (16)  
                                                                                                                                                     
 Gross Profit               5,240     58             44                                    -                  -       5,342    5,606     4     (5)   
 Gross Margin3              81.7%                                                                                     83.5%    82.1%     +1.1  +1.4  
                                                                                                                                                     
 Distribution               (84)      -              -                                     -                  -       (84)     (77)      27    10    
 % Total Revenue            1.3%                                                                                      1.3%     1.1%      -0.3  -0.2  
                                                                                                                                                     
 R&D                        (1,466)   62             48                                    -                  -       (1,356)  (1,208)   23    12    
 % Total Revenue            23.2%                                                                                     21.5%    17.9%     -3.7  -3.6  
                                                                                                                                                     
 SG&A                       (2,966)   115            242                                   108                285     (2,216)  (2,460)   (1)   (10)  
 % Total Revenue            47.0%                                                                                     35.1%    36.4%     +1.2  +1.3  
                                                                                                                                                     
 Other Operating Income     199       -              86                                    -                  (158)   127      170       (12)  (25)  
 % Total Revenue            3.2%                                                                                      2.0%     2.5%      -0.3  -0.5  
                                                                                                                                                     
 Operating Profit           923       235            420                                   108                127     1,813    2,031     (4)   (11)  
 % Total Revenue            14.6%                                                                                     28.7%    30.0%     -1.7  -1.3  
                                                                                                                                                     
 Net FinanceExpense         (263)     -              -                                     100                31      (132)    (141)                 
 Joint Ventures             (2)       -              -                                     -                  -       (2)      -                     
                                                                                                                                                     
 Profit Before Tax          658       235            420                                   208                158     1,679    1,890     (2)   (11)  
 Taxation                   38        (49)           (104)                                 (47)               2       (160)    (247)                 
 Tax Rate                   -5.8%                                                                                     9.5%     13.1%                 
 Profit After Tax           696       186            316                                   161                160     1,519    1,643     3     (8)   
                                                                                                                                                     
 Non-controlling Interests  1         -              -                                     -                  -       1        (1)                   
 Net Profit                 697       186            316                                   161                160     1,520    1,642     3     (8)   
                                                                                                                                                     
 Weighted Average Shares    1,264     1,264          1,264                                 1,264              1,264   1,264    1,262                 
                                                                                                                                                     
 Earnings Per Share         0.55      0.15           0.25                                  0.13               0.13    1.21     1.30      3     (8)   
 
 
  
 
 1 Other adjustments include provision charges and settlement income related to certain legal matters (see Note 5) and fair value adjustments to contingent consideration liabilities arising on business combinations (see Note 4).  
 2 2014 comparatives have been restated to reflect the reclassification of Externalisation Revenue from Other Operating Income.                                                                                                       
 3 Gross Margin reflects Gross Profit derived from Product Sales, divided by Product Sales.                                                                                                                                           
 
 
Gross Profit 
 
Core gross profit increased by 3% in the half to $10,446m. Excluding the impact of externalisation, the Core gross profit
margin increased by 1% point. Drivers of the margin increase included the mix of Product Sales, the contribution from the
growth platforms and additional manufacturing efficiencies. 
 
Operating Expenses 
 
Core R&D costs were up 24% in the half to $2,636m as the Company continued its accelerated investment in the pipeline. The
Company anticipates a lower growth rate in the second half of the year. 
 
Core SG&A costs were up 4% to $4,584m in the half as the Company continued to invest in the product launch programme and
the growth platforms; costs declined by 1% in the second quarter, reflecting the third successive quarter of falling Core
SG&A costs as a proportion of Total Revenue. In the second quarter, Core SG&A costs represented 35% of Total Revenue,
compared to 39% in Q1 2015 and 44% in Q4 2014. 
 
The Company is committed to reducing Core SG&A costs in 2015 versus the prior year, both in terms of absolute value and,
importantly, relative to Total Revenue. A number of programmes designed to meet this target are in progress. These
initiatives are centred on: 
 
-      Sales, marketing and medical-cost effectiveness 
 
-      Centralisation of selected functions and process improvements 
 
-      Reduced third-party spend 
 
-      Additional efficiencies gained across support functions and IT 
 
-      Continued footprint optimisation, including presence in the UK and US 
 
Resources are being deployed more opportunistically to meet changing customer needs and the evolving portfolio, while
driving top-line growth more efficiently. 
 
Other Operating Income 
 
Core Other Operating Income of $553m in the half included gains on the disposal of Myalept ($193m) and other disposals
amounting to $120m, including the US rights to Tenormin. 
 
Operating Profit 
 
Core Operating Profit was down 4% to $3,618m in the half. Core Operating Margin declined by 1.5% points to 29.3% of Total
Revenue as the Company continued to invest in the pipeline and the growth platforms. 
 
Finance Expense 
 
Core net finance expense was $250m versus $267m in the first half of 2014. Reported net finance expense of $513m included a
charge of $263m relating to the discount unwind on contingent consideration creditors recognised on business combinations,
principally relating to the acquisition of BMS's share of the global diabetes alliance last year. 
 
Taxation 
 
Excluding the one-off tax benefit of $186m following settlement of past years' US federal tax liabilities, both the Core
and Reported tax rates for the half year were around 20%. Including the impact of this benefit, the Core and Reported tax
rates for the half year were 14% and 7% respectively. The cash tax paid for the half year was $782m, which is 59% of
Reported Profit Before Tax and 23% of Core Profit Before Tax. 
 
The Core and Reported tax rates for the first half of 2014 were 19% and 21% respectively when excluding the impact of a
one-off tax benefit of $117m in respect of prior periods following the inter-governmental agreement of a transfer pricing
matter. Including the impact of this benefit, the Core and Reported tax rates for the first half of 2014 were 16% and 13%
respectively. The cash tax paid for the first half of 2014 was $736m, which was 49% of Reported Profit Before Tax and 20%
of Core Profit Before Tax. 
 
Earnings Per Share (EPS) 
 
Core EPS in the half was stable at $2.29, a favourable performance versus Core Operating Profit due to a one-off tax
benefit in the second quarter. Reported Operating Profit of $1,856m was 1% higher than the first half of 2014. Reported EPS
was up by 2% at $0.99. 
 
Productivity 
 
Restructuring charges of $448m were taken in the first half of 2015, including $101m incurred on initiatives identified
since the announcement of the fourth wave of restructuring. 
 
The Company continues to make good progress in implementing the fourth wave of restructuring that was announced in 2013 and
expanded in 2014. It remains on track to incur $3.2bn in one-time restructuring costs and to deliver annualised benefits of
$1.1bn by the end of 2016. In addition to the fourth wave of restructuring an additional $600m of costs are estimated to be
incurred by the end of 2016 (of which $362m has been incurred to date) associated with previously-announced site exits
(including Avlon in the UK) and the integration of businesses acquired since the beginning of 2014. 
 
It is anticipated that, once completed, the total annualised benefits of these additional actions will be $200m, bringing
the total annualised benefit of all ongoing restructuring activities to $1.3bn by the end of 2016. 
 
Cash Flow 
 
The Company generated a cash inflow from operating activities of $1,008m in the half, compared with an inflow of $3,266m in
the first half of 2014, reflecting the operational performance of the business. Net cash outflows from investing activities
were $1,234m compared with $4,955m in the first half of 2014, primarily reflecting the acquisition of the BMS share of the
global diabetes alliance last year. The Company has embarked upon an initiative to further improve cash generation from the
business including standardisation of global processes and payment terms. 
 
Net cash distributions to shareholders were $2,337m through dividends of $2,357m, offset by proceeds from the issue of
shares of $20m due to the exercise of stock options. 
 
Debt and Capital Structure 
 
At 30 June 2015, outstanding gross debt (interest-bearing loans and borrowings) was $11,008m (30 June 2014: $10,074m). Of
the gross debt outstanding at 30 June 2015, $2,705m was due within one year (30 June 2014: $2,500m). 
 
The Company's net debt position at 30 June 2015 was $5,994m (30 June 2014: $3,959m). 
 
Shares in Issue 
 
During the half, 0.5 million shares were issued in respect of share option exercises for a consideration of $20m. The total
number of shares in issue at 30 June 2015 was 1,264 million. 
 
Dividends 
 
The Board has recommended an unchanged first interim dividend of $0.90 (57.5 pence, 7.71 SEK) per Ordinary Share. 
 
For holders of the Company's American Depositary Shares (ADSs) this equates to $0.45 per ADS. Following the ratio change to
the Company's NYSE-listed sponsored Level 2 American Depositary Receipt programme on 27 July 2015, two ADSs equal one
Ordinary Share. 
 
The level of the dividend per share reflects the Board's aim of setting the first interim dividend at around a third of the
prior-year dividend, which for FY 2014 was $2.80 per Ordinary Share. 
 
The Board has adopted a progressive dividend policy, by which the Board intends to maintain or grow the dividend per share
each year. In adopting this policy, the Board recognises that some earnings fluctuations are to be expected as the
Company's revenue base transitions through a period of exclusivity losses and new-product launches. 
 
In setting the distribution policy and the overall financial strategy, the Board's aim is to continue to strike a balance
between the interests of the business, financial creditors and the Company's shareholders. After providing for business
investment, funding the progressive dividend policy and meeting debt-service obligations, the Board will keep under review
the opportunity to return cash in excess of these requirements to shareholders through periodic share repurchases. However,
the Board has decided that no share repurchases will take place in 2015 in order to maintain the strategic flexibility to
invest in the business. 
 
FY 2015 Guidance 
 
The Company today revises its Total Revenue guidance at CER from that provided on 24 April 2015. Total Revenue in the full
year is now expected to decline by low single-digit percent versus the prior guidance of a mid single-digit decline. Core
EPS guidance at CER for the year is unchanged and Core EPS is expected to increase by low single-digit percent, reflecting
the continued accelerated investment in R&D. 
 
The Company also provides the following non-guidance information related to currency sensitivity: Based on current exchange
rates1, Total Revenue is expected to decline by high single-digit percent with Core EPS expected to be broadly in line with
FY 2014. For additional currency sensitivity information, please see below: 
 
                                  Average Exchange Rates Versus USD                Impact Of 5% Weakening In Exchange Rate Versus USD ($m)2  
 Currency    Primary Relevance    FY 2014                              H1 20151    Change %                                                    Total Revenue    Core Operating Profit  
 EUR         Product Sales        0.75                                 0.89        (16)                                                        (225)            (138)                  
 JPY         Product Sales        105.87                               120.25      (12)                                                        (119)            (84)                   
 CNY         Product Sales        6.16                                 6.22        (1)                                                         (115)            (49)                   
 SEK         Costs                6.86                                 8.37        (18)                                                        (6)              114                    
 GBP         Costs                0.61                                 0.66        (7)                                                         (37)             112                    
 Other3                                                                                                                                        (242)            (139)                  
                                                                                                                                                                                       
                                                                                                                                                                                                 
 
 
1 Based on average daily spot rates YTD to the end of June 2015 
 
2 Based on 2014 actual average exchange rates and group currency exposures 
 
3 Other important currencies include AUD, BRL, CAD, KRW and RUB 
 
Related Party Transactions 
 
There have been no significant related party transactions in the period. 
 
Principal Risks and Uncertainties 
 
It is not anticipated that the nature of the principal risks and uncertainties that affect the business, and which are set
out on pages 205 to 219 of the Annual Report and Form 20-F Information 2014, will change in respect of the second six
months of the financial year. 
 
In summary, the principal risks and uncertainties listed in the Annual Report and 20-F Information 2014 are: 
 
a) Product pipeline risks 
 
Failure to meet development targets; difficulties of obtaining and maintaining regulatory approvals for new products;
failure to obtain and enforce effective intellectual property protection; delay to new product launches; strategic
alliances and acquisitions may be unsuccessful. 
 
b) Commercialisation and business execution risks 
 
Challenges to achieving commercial success of new products; illegal trade in our products; developing our business in
Emerging Markets; expiry or loss of, or limitations on, intellectual property rights; pressures resulting from generic
competition; effects of patent litigation in respect of intellectual property rights; price controls and price reductions;
economic, regulatory and political pressures; biosimilars; increasing implementation and enforcement of more stringent
anti-bribery and anti-corruption legislation; any expected gains from productivity initiatives are uncertain; changes in
senior management, failure to attract and retain key personnel and failure to successfully engage with our employees;
failure of information technology; failure of outsourcing. 
 
c) Supply chain and delivery risks 
 
Manufacturing biologics; difficulties and delays in the manufacturing, distribution and sale of our products; reliance on
third parties for goods. 
 
d) Legal, regulatory and compliance risks 
 
Adverse outcome of litigation and/or governmental investigations; substantial product liability claims; failure to adhere
to applicable laws, rules and regulations; failure to adhere to laws, rules and regulations relating to anti-competitive
behaviour; environmental and occupational health and safety liabilities; misuse of social media platforms and new
technology. 
 
e) Economic and financial risks 
 
Adverse impact of a sustained economic downturn; political and socio-economic conditions; impact of fluctuations in
exchange rates; limited third party insurance coverage; taxation; pensions. 
 
Condensed Consolidated Statement of Comprehensive Income 
 
 Product sales                                                                  11,584     12,870   
 Externalisation revenue                                                        780        352      
 Total revenue                                                                  12,364     13,222   
 Cost of sales                                                                  (2,336)    (2,760)  
 Gross profit                                                                   10,028     10,462   
 Distribution costs                                                             (161)      (149)    
 Research and development expense                                               (2,822)    (2,528)  
 Selling, general and administrative costs                                      (5,765)    (5,784)  
 Other operating income and expense                                             576        (56)     
 Operating profit                                                               1,856      1,945    
 Finance income                                                                 24         26       
 Finance expense                                                                (537)      (467)    
 Share of after tax losses in joint ventures                                    (7)        -        
 Profit before tax                                                              1,336      1,504    
 Taxation                                                                       (88)       (201)    
 Profit for the period                                                          1,248      1,303    
                                                                                                    
 Other comprehensive income                                                                         
 Items that will not be reclassified to profit or loss                                              
 Remeasurement of the defined benefit pension liability                         242        (288)    
 Tax on items that will not be reclassified to profit or loss                   (57)       85       
                                                                                185        (203)    
 Items that may be reclassified subsequently to profit or loss                                      
 Foreign exchange arising on consolidation                                      (11)       64       
 Foreign exchange arising on designating borrowings in net investment hedges    (217)      (122)    
 Fair value movements on derivatives designated in net investment hedges        20         (11)     
 Amortisation of loss on cash flow hedge                                        1          1        
 Net available for sale (losses)/gains taken to equity                          (29)       49       
 Tax on items that may be reclassified subsequently to profit or loss           43         5        
                                                                                (193)      (14)     
 Other comprehensive income for the period, net of tax                          (8)        (217)    
 Total comprehensive income for the period                                      1,240      1,086    
                                                                                                    
 Profit attributable to:                                                                            
 Owners of the Parent                                                           1,247      1,300    
 Non-controlling interests                                                      1          3        
                                                                                1,248      1,303    
                                                                                                    
 Total comprehensive income attributable to:                                                        
 Owners of the Parent                                                           1,239      1,089    
 Non-controlling interests                                                      1          (3)      
                                                                                1,240      1,086    
                                                                                                    
 Basic earnings per $0.25 Ordinary Share                                        $0.99      $1.03    
 Diluted earnings per $0.25 Ordinary Share                                      $0.99      $1.03    
 Weighted average number of Ordinary Shares in issue (millions)                 1,263      1,261    
 Diluted weighted average number of Ordinary Shares in issue (millions)         1,265      1,263    
 
 
1,086 
 
Basic earnings per $0.25 Ordinary Share 
 
$0.99 
 
$1.03 
 
Diluted earnings per $0.25 Ordinary Share 
 
$0.99 
 
$1.03 
 
Weighted average number of Ordinary Shares in issue (millions) 
 
1,263 
 
1,261 
 
Diluted weighted average number of Ordinary Shares in issue (millions) 
 
1,265 
 
1,263 
 
* 2014 comparatives restated for reclassification of Externalisation revenue (see Note 1) 
 
Condensed Consolidated Statement of Comprehensive Income 
 
 Product sales                                                                  5,836      6,454    
 Externalisation revenue                                                        471        308      
 Total revenue                                                                  6,307      6,762    
 Cost of sales                                                                  (1,067)    (1,307)  
 Gross profit                                                                   5,240      5,455    
 Distribution costs                                                             (84)       (77)     
 Research and development expense                                               (1,466)    (1,328)  
 Selling, general and administrative costs                                      (2,966)    (3,058)  
 Other operating income and expense                                             199        117      
 Operating profit                                                               923        1,109    
 Finance income                                                                 13         10       
 Finance expense                                                                (276)      (253)    
 Share of after tax losses of joint ventures                                    (2)        -        
 Profit before tax                                                              658        866      
 Taxation                                                                       38         (69)     
 Profit for the period                                                          696        797      
                                                                                                    
 Other comprehensive income                                                                         
 Items that will not be reclassified to profit or loss                                              
 Remeasurement of the defined benefit pension liability                         259        (263)    
 Tax on items that will not be reclassified to profit or loss                   (61)       79       
                                                                                198        (184)    
 Items that may be reclassified subsequently to profit or loss                                      
 Foreign exchange arising on consolidation                                      438        9        
 Foreign exchange arising on designating borrowings in net investment hedges    191        (121)    
 Fair value movements on derivatives designated in net investment hedges        (1)        (2)      
 Amortisation of loss on cash flow hedge                                        1          1        
 Net available for sale (losses)/gains taken to equity                          (48)       47       
 Tax on items that may be reclassified subsequently to profit or loss           (57)       12       
                                                                                524        (54)     
 Other comprehensive income for the period, net of tax                          722        (238)    
 Total comprehensive income for the period                                      1,418      559      
                                                                                                    
 Profit attributable to:                                                                            
 Owners of the Parent                                                           697        796      
 Non-controlling interests                                                      (1)        1        
                                                                                696        797      
                                                                                                    
 Total comprehensive income attributable to:                                                        
 Owners of the Parent                                                           1,418      558      
 Non-controlling interests                                                      -          1        
                                                                                1,418      559      
                                                                                                    
 Basic earnings per $0.25 Ordinary Share                                        $0.55      $0.63    
 Diluted earnings per $0.25 Ordinary Share                                      $0.55      $0.63    
 Weighted average number of Ordinary Shares in issue (millions)                 1,264      1,262    
 Diluted weighted average number of Ordinary Shares in issue (millions)         1,265      1,264    
 
 
559 
 
Basic earnings per $0.25 Ordinary Share 
 
$0.55 
 
$0.63 
 
Diluted earnings per $0.25 Ordinary Share 
 
$0.55 
 
$0.63 
 
Weighted average number of Ordinary Shares in issue (millions) 
 
1,264 
 
1,262 
 
Diluted weighted average number of Ordinary Shares in issue (millions) 
 
1,265 
 
1,264 
 
* 2014 comparatives restated for reclassification of Externalisation revenue (see Note 1) 
 
Condensed Consolidated Statement of Financial Position 
 
 ASSETS Non-current assets                                                                               
 Property, plant and equipment                                         6,134       6,010       6,150     
 Goodwill                                                              11,467      11,550      11,560    
 Intangible assets                                                     20,486      20,981      21,150    
 Derivative financial instruments                                      471         465         349       
 Investments in joint ventures                                         52          59          70        
 Other investments                                                     448         502         289       
 Other receivables                                                     957         1,112       1,380     
 Deferred tax assets                                                   1,342       1,219       1,387     
                                                                       41,357      41,898      42,335    
 Current assets                                                                                          
 Inventories                                                           2,198       1,960       2,249     
 Trade and other receivables                                           6,615       7,232       7,817     
 Other investments                                                     531         795         819       
 Derivative financial instruments                                      51          21          1         
 Income tax receivable                                                 450         329         360       
 Cash and cash equivalents                                             3,967       6,360       4,958     
                                                                       13,812      16,697      16,204    
 Total assets                                                          55,169      58,595      58,539    
 LIABILITIES Current liabilities                                                                         
 Interest-bearing loans and borrowings                                 (2,705)     (2,446)     (2,500)   
 Trade and other payables                                              (10,659)    (11,886)    (10,304)  
 Derivative financial instruments                                      (6)         (21)        (12)      
 Provisions                                                            (731)       (623)       (679)     
 Income tax payable                                                    (2,049)     (2,354)     (2,827)   
                                                                       (16,150)    (17,330)    (16,322)  
 Non-current liabilities                                                                                 
 Interest-bearing loans and borrowings                                 (8,303)     (8,397)     (7,574)   
 Deferred tax liabilities                                              (1,582)     (1,796)     (2,427)   
 Retirement benefit obligations                                        (2,377)     (2,951)     (2,634)   
 Provisions                                                            (479)       (484)       (580)     
 Other payables                                                        (7,979)     (7,991)     (6,950)   
                                                                       (20,720)    (21,619)    (20,165)  
 Total liabilities                                                     (36,870)    (38,949)    (36,487)  
 Net assets                                                            18,299      19,646      22,052    
 EQUITY                                                                                                  
 Capital and reserves attributable to equity holders of the Company                                      
 Share capital                                                         316         316         316       
 Share premium account                                                 4,281       4,261       4,236     
 Other reserves                                                        2,033       2,021       1,973     
 Retained earnings                                                     11,649      13,029      15,504    
                                                                       18,279      19,627      22,029    
 Non-controlling interests                                             20          19          23        
 Total equity                                                          18,299      19,646      22,052    
 
 
19,627 
 
22,029 
 
Non-controlling interests 
 
20 
 
19 
 
23 
 
Total equity 
 
18,299 
 
19,646 
 
22,052 
 
Condensed Consolidated Statement of Cash Flows 
 
 Cash flows from operating activities                                                    
 Profit before tax                                                   1,336      1,504    
 Finance income and expense                                          513        441      
 Share of after tax losses in joint ventures                         7          -        
 Depreciation, amortisation and impairment                           1,565      1,410    
 (Increase)/decrease in working capital and short-term provisions    (767)      703      
 Non-cash and other movements                                        (612)      216      
 Cash generated from operations                                      2,042      4,274    
 Interest paid                                                       (252)      (272)    
 Tax paid                                                            (782)      (736)    
 Net cash inflow from operating activities                           1,008      3,266    
 Cash flows from investing activities                                                    
 Movement in short-term investments and fixed deposits               273        34       
 Purchase of property, plant and equipment                           (497)      (378)    
 Disposal of property, plant and equipment                           16         133      
 Purchase of intangible assets                                       (1,222)    (1,490)  
 Disposal of intangible assets                                       350        -        
 Purchase of non-current asset investments                           (30)       (5)      
 Disposal of non-current asset investments                           56         -        
 Payments to joint ventures                                          -          (70)     
 Upfront payments on business acquisitions                           -          (2,778)  
 Payment of contingent consideration on business acquisitions        (239)      (449)    
 Interest received                                                   59         58       
 Payments made by subsidiaries to non-controlling interests          -          (10)     
 Net cash outflow from investing activities                          (1,234)    (4,955)  
 Net cash outflow before financing activities                        (226)      (1,689)  
 Cash flows from financing activities                                                    
 Proceeds from issue of share capital                                20         254      
 Repayment of loans                                                  (884)      (750)    
 Dividends paid                                                      (2,357)    (2,425)  
 Hedge contracts relating to dividend payments                       (43)       25       
 Repayment of obligations under finance leases                       (34)       (17)     
 Payments to acquire non-controlling interest                        -          (102)    
 Movement in short-term borrowings                                   910        445      
 Net cash outflow from financing activities                          (2,388)    (2,570)  
 Net decrease in cash and cash equivalents in the period             (2,614)    (4,259)  
 Cash and cash equivalents at the beginning of the period            6,164      8,995    
 Exchange rate effects                                               (29)       3        
 Cash and cash equivalents at the end of the period                  3,521      4,739    
 Cash and cash equivalents consists of:                                                  
 Cash and cash equivalents                                           3,967      4,958    
 Overdrafts                                                          (446)      (219)    
                                                                     3,521      4,739    
 
 
4,958 
 
Overdrafts 
 
(446) 
 
(219) 
 
3,521 
 
4,739 
 
Condensed Consolidated Statement of Changes in Equity 
 
                                                        Share       Share       Other         Retained     Total      Non-            Total    
                                                        capital     premium     reserves*     earnings     $m         controlling     equity   
                                                        $m          account     $m            $m                      interests       $m       
                                                                    $m                                                $m                       
 At 1 Jan 2014                                          315         3,983       1,966         16,960       23,224     29              23,253   
 Profit for the period                                  -           -           -             1,300        1,300      3               1,303    
 Other comprehensive income                             -           -           -             (211)        (211)      (6)             (217)    
 Transfer to other reserves                             -           -           7             (7)          -          -               -        
 Transactions with owners:                                                                                                                     
 Dividends                                              -           -           -             (2,395)      (2,395)    -               (2,395)  
 Issue of Ordinary Shares                               1           253         -             -            254        -               254      
 Share-based payments                                   -           -           -             (143)        (143)      -               (143)    
 Transfer from non-controlling interests to payables    -           -           -             -            -          (3)             (3)      
 Net movement  

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