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REG - GlaxoSmithKline PLC - 1st Quarter Results <Origin Href="QuoteRef">GSK.L</Origin> - Part 2

- Part 2: For the preceding part double click  ID:nRSF3482Ma 

to £1,885 million 
 and represented a total effective tax rate of 19.0% (Q1 2014: 20.4%), reflecting the differing tax effects of the various non-core items.  See 'Taxation' on page 36 for further details. Total EPS was 167.8p, compared with 13.9p in Q1 2014, primarily reflecting the profits on disposal of the Oncology business and the Aspen Pharmacare shares, partly offset by the increase in the liability for the contingent consideration for the acquisition of the former Shionogi-ViiV Healthcare joint venture.                
 
 
 Cash generation and conversion  
 
 
 Cash flow and net debt  
 
 
                                                                                                                                                           Q1 2015    Q1 2014  
                                                                                                                                                                               
 Net cash inflow from operating activities (£m)                                                                                                            370        927      
 Adjusted net cash inflow from operating activities* (£m)                                                                                                  532        968      
 Free cash flow* (£m)                                                                                                                                      (69)       467      
 Adjusted free cash flow* (£m)                                                                                                                             93         508      
 Free cash flow growth (%)                                                                                                                                 >(100)%    (40)%    
 Free cash flow conversion* (%)                                                                                                                            1%         67%      
 Net debt (£m)                                                                                                                                             8,098      13,660   
                                                                                                                                                                               
 *  Adjusted net cash inflow from operating activities, free cash flow, adjusted free cash flow and free cash flow conversion are defined on page 26.  
 
 
 The net cash inflow from operating activities for the quarter was £370 million (Q1 2014: £927 million).  Excluding legal settlements of £162 million (Q1 2014: £41 million), the adjusted net cash inflow from operating activities was £532 million (Q1 2014: £968 million), a 45% decrease compared with 2014.  This primarily reflected the combined impact of lower operating profits and increased cash outflows on restructuring items. Free cash flow was £(69) million for the quarter.  Excluding legal payments,      
 adjusted free cash flow was £93 million (Q1 2014: £508 million).  The decrease primarily reflected the combined impact of lower operating profits and increased cash outflows on restructuring items.  The Group paid dividends to shareholders of £924 million. Free cash flow conversion was impacted by the profits on disposal of the Oncology business and the Aspen stake. At 31 March 2015, net debt was £8.1 billion, compared with £14.4 billion at 31 December 2014, comprising gross debt of £18.5 billion and cash  
 and liquid investments of £10.4 billion.  The decrease in net debt reflected the impact of the Novartis transaction in which GSK sold its Oncology business for net cash proceeds of £10.1 billion and paid £3.3 billion to acquire the Novartis businesses.  Tax liabilities on the transaction are yet to be settled.  In addition, GSK sold 6.2% of its shareholding in Aspen for cash proceeds of £564 million, reducing the shareholding from 12.4% to 6.2%.  At 31 March 2015, GSK had short-term borrowings (including   
 overdrafts) repayable within 12 months of £3,240 million with no loans repayable in the subsequent year.                                                                                                                                                                                                                                                                                                                                                                                                                        
 
 
 Working capital  
 
 
                                                             31 March    31 December    30 September    30 June    31 March  
                                                             2015        2014           2014            2014       2014      
                                                                                                                             
 Working capital conversion cycle* (days)                    215         209            216             208        205       
 Working capital percentage of turnover (%)                  24          22             24              22         22        
                                                                                                                             
 *  Working capital conversion cycle is defined on page 26.  
 
 
 During the quarter, working capital was significantly impacted by the Novartis transaction which increased the working capital conversion cycle by 11 days.  This principally resulted from inventory acquired with the former Novartis Vaccines business.  The increase was partly offset by a six day reduction in the cycle from favourable exchange effects.  The conversion cycle of the underlying businesses increased by one day from the position at 31 December 2014.  
 
 
 Returns to shareholders  
 
 
 GSK expects to pay an annual ordinary dividend of 80p for each of the next three years (2015-2017). GSK also plans to return approximately £1 billion (20p per share) to shareholders via a special dividend to be paid alongside GSK's Q4 2015 ordinary dividend payment. Any future returns to shareholders of surplus capital will be subject to the Group's strategic progress, visibility on the put options associated with ViiV Healthcare and the Consumer Healthcare joint venture and other capital requirements.     
 Quarterly dividendsThe Board has declared a first interim dividend of 19 pence per share (Q1 2014: 19 pence per share). Payment of dividendsThe equivalent interim dividend receivable by ADR holders will be calculated based on the exchange rate on 7 July 2015.  With effect from and including this dividend, an annual fee of $0.02 per ADS (or $0.005 per ADS per quarter) will be charged by the Depositary. The ex-dividend date will be 14 May 2015 (13 May 2015 for ADR holders), with a record date of 15 May 2015  
 and a payment date of 9 July 2015.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
 
 
                 Paid/             Pence per    £m     
                 payable           share               
                                                       
 2015                                                  
 First interim   9 July 2015       19           918    
                                                       
 2014                                                  
 First interim   10 July 2014      19           916    
 Second interim  2 October 2014    19           918    
 Third interim   8 January 2015    19           924    
 Fourth interim  9 April 2015      23           1,114  
                                                       
                                   80           3,872  
                                                       
 
 
 GSK made no share repurchases during the quarter.  The company issued 2.0 million shares under employee share schemes amounting to £28 million (Q1 2014: £81 million). The weighted average number of shares for Q1 2015 was 4,820 million, compared with 4,802 million in Q1 2014.  
 
 
 Segmental performance  
 
 
 Global Pharmaceuticals  Q1 2015    Q1 2015   
                                                           
                         £m         Reported    Pro-forma  
                                    growth      growth     
                                    CER%        CER%       
                                                           
 US                      1,019      (23)        (21)       
 Europe                  815        (7)         (3)        
 International           1,243      (5)         (4)        
                                                           
                         3,077      (12)        (10)       
                                                           
 
 
                                        Q1 2015  
                                                           
                                        £m         Growth  
                                                   CER%    
                                                           
 Respiratory                            1,408      (9)     
 Oncology                               216        (18)    
 Cardiovascular, metabolic and urology  218        (8)     
 Immuno-inflammation                    60         19      
 Other pharmaceuticals                  525        (9)     
 Established Products                   650        (20)    
                                                           
                                        3,077      (12)    
                                                           
 
 
 Respiratory Q1 2015 (£1,408million; down 9%)Respiratory sales in the quarter declined 9% to £1,408 million.  Seretide/Advair sales were down 14% to £898 million, Flixotide/Flovent sales decreased 22% to £153 million and Ventolin sales fell 9% to £161 million.  Relvar/Breo Ellipta recorded sales of £41 million and Anoro Ellipta, now launched in the US, Europe and Japan, recorded sales of £12 million in the quarter. In the US, Respiratory sales declined 22% to £583 million in the quarter (1% volume growth and 
 a 23% negative impact of price and mix).  The negative price and mix impact reflects new contracts agreed in 2014 in response to competitive pressures in both the ICS/LABA combination market, where Advair and Breo Ellipta compete, and also the LABA/LAMA combination market, where Anoro Ellipta is marketed.  Sales of Advair were down 21% (3% volume decline and an 18% negative impact of price and mix).  Flovent sales were down 38% to £83 million and Ventolin sales fell 24%.  The reported declines for both     
 Flovent and Ventolin reflected the net negative impact of true up adjustments to accruals for returns and rebates recorded in both Q1 2014 and Q1 2015.  Excluding the impact of true up adjustments and stocking patterns, on an estimated underlying basis Flovent sales declined 6% while Ventolin grew 13%.  Breo Ellipta recorded sales of £14 million, and Anoro Ellipta, launched in Q2 2014, recorded sales of £9 million in the quarter. European Respiratory sales were down 4% to £392 million, with Seretide sales  
 down 11% to £291 million (4% decline in volume and a 7% negative impact of price), reflecting increasing competitive pressures and the transition of the Respiratory portfolio to the newer products.  Relvar Ellipta, approved in Europe for both COPD and asthma, recorded sales of £16 million in the quarter, while Anoro Ellipta, with launches now underway in many countries throughout the region, recorded sales of £2 million. Respiratory sales in the International region grew 5% to £433 million with Emerging    
 Markets up 7% and Japan up 1%.  In Emerging Markets, sales of Seretide increased 6% to £125 million, while Ventolin grew 8% to £46 million.  In Japan, the sales of Relvar Ellipta of £9 million in the quarter, together with strong growth in Veramyst and Xyzal sales, more than offset the 27% decline in Adoair as a result of comparison with a strong Q1 2014 which benefited from wholesaler stocking.  Oncology Q1 2015 (£216million;down 18%)Oncology sales for the first two months were £216 million, down 18% on a 
 reported basis compared with Q1 2014, but up 25% on a pro-forma basis.   Cardiovascular, metabolic and urology Q1 2015 (£218million; down8%)Sales in the category fell 8% to £218 million.  The Avodart franchise fell 7% to £179 million, with 13% growth in sales of Duodart/Jalyn offset by a 15% decline in sales of Avodart.  Sales of Prolia decreased 33% to £9 million, due to the agreement in Q2 2014 with Amgen to terminate the joint commercialisation in a number of European markets, Mexico and Russia.  Immuno 
 -inflammation Q1 2015 (£60million;up 19%)Immuno-inflammation sales grew 19% to £60 million.  Benlysta turnover in the quarter was £51 million, up 23%.  In the US, Benlysta sales were £46 million, up 26%.  Other pharmaceuticals Q1 2015 (£525million; down9%)Sales in other therapy areas fell 9% to £525 million.  Augmentin sales declined 3% to £140 million and Dermatology sales declined 11% to £109 million both impacted by supply constraints due to capacity limitations.  Relenza sales were down 25% to £30      
 million in the quarter reflecting Japanese government stockpiling in Q1 2014 which was not repeated in Q1 2015.  Sales of products for Rare diseases declined 10% to £91 million, primarily as a result of generic competition to Mepron in the US.  Established Products Q1 2015 (£650million; down 20%)Established Products turnover fell 20% to £650 million.  Sales in the US were down 42% to £163 million, primarily attributable to a 75% fall in sales of Lovaza to £28 million, due to generic competition which began 
 in April 2014 and has intensified during 2015. Europe was down 14% to £132 million with Seroxat sales falling 33% to £8 million, reflecting increased generic competition to a number of other products and a number of supply constraints.  International was down 8% to £355 million, primarily reflecting lower sales of Seroxat/Paxil due to generic competition in Japan and some supply constraints, together with the impact of competitive and price pressures to Zeffix and Hepsera in China.                          
 
 
 ViiV Healthcare  Q1 2015    Q1 2015   
                                                    
                  £m         Reported    Pro-forma  
                             growth      growth     
                             CER%        CER%       
                                                    
 US               229        66          66         
 Europe           154        35          35         
 International    63         9           9          
                                                    
                  446        42          42         
                                                    
 
 
                     Q1 2015  
                                        
                     £m         Growth  
                                CER%    
                                        
 Epzicom/Kivexa      176        2       
 Selzentry           30         (9)     
 Tivicay             112        >100    
 Triumeq             81         -       
 Other               47         (33)    
                                        
                     446        42      
                                        
 
 
 Q1 2015 (£446million;up 42%)ViiV Healthcare sales increased 42% in the quarter, with the US up 66%, Europe up 35% and International up 9%.  The growth in all three regions was driven by Tivicay and Triumeq. The ongoing roll-out of Tivicay resulted in sales of £112 million and Triumeq, now launched in the US and much of Europe recorded sales of £81 million in the quarter.  Epzicom/Kivexa, which benefited from use in combination with Tivicay, increased 2% to £176 million, but Selzentry sales fell 9% to £30   
 million.  There were also continued declines in the mature portfolio, mainly driven by generic competition to both Combivir, down 38% to £10 million, and Lexiva, down 27% to £16 million.                                                                                                                                                                                                                                                                                                                                      
 
 
 Vaccines       Q1 2015    Q1 2015   
                                                  
                £m         Reported    Pro-forma  
                           growth      growth     
                           CER%        CER%       
                                                  
 US             217        14          11         
 Europe         224        4           (3)        
 International  258        13          3          
                                                  
                699        10          3          
                                                  
 
 
                     Q1 2015    Q1 2015   
                                                       
                     £m         Reported    Pro-forma  
                                growth      growth     
                                CER%        CER%       
                                                       
 Rotarix             98         14          14         
 Synflorix           60         7           7          
 Fluarix, FluLaval   4          (63)        (63)       
                                                       
 Bexsero             7          -           >100       
 Menveo              11         -           -          
                                                       
 Boostrix            66         7           7          
 Infanrix, Pediarix  186        (6)         (6)        
 Hepatitis           143        17          17         
 Cervarix            28         (14)        (14)       
 Other               96         38          (2)        
                                                       
                     699        10          3          
                                                       
 
 
 Q1 2015 (£699million;up 10%)Vaccines sales grew 10% to £699 million with the US up 14%, Europe up 4% and International up 13%.  The business benefited from one month of sales of the former Novartis products, and pro-forma growth for the quarter was 3%. In the US, reported growth of 14% (11% pro-forma) primarily reflected strong growth in Hepatitis vaccines which benefited from variations in CDC stockpile shipments and the replenishment of wholesaler inventory levels.  Rotarix sales, up 12%, also benefited  
 from the replenishment of wholesaler inventory levels in the quarter.  This growth was partly offset by lower sales of Infanrix/Pediarix as a result of the return to the market of a competitor vaccine during 2014. In Europe, sales grew 4% on a reported basis to £224 million, but declined 3% on a pro-forma basis.  This was largely attributable to a 9% fall in Infanrix/Pediarix sales, which were impacted by the introduction of a competitor vaccine in 2014 and the phasing of shipments in several countries.    
 Sales of Hepatitis vaccines declined 4% and Cervarix sales were down 27% in part due to the phasing of shipments.  These declines were partly offset by a 27% increase in Boostrix sales driven by better supply in comparison with Q1 2014. International sales of £258 million grew 13% on a reported basis and 3% pro-forma, benefiting from the phasing of shipments of a number of products in both Q1 2015 and Q1 2014.  Synflorix sales grew 12%, primarily reflecting the phasing of tender shipments.  Hepatitis       
 vaccines grew 20% mainly driven by the phasing of Havrix sales in the Middle East, but Boostrix sales fell 25%, reflecting the phasing of tender shipments in Brazil and the Middle East.  Fluarix/FluLaval sales declined 75% due to the phasing of shipments in Brazil and Asia Pacific.                                                                                                                                                                                                                                      
 
 
 Consumer Healthcare  
 
 
 Turnover           Q1 2015    Q1 2015   
                                                      
                    £m         Reported    Pro-forma  
                               growth      growth     
                               CER%        CER%       
                                                      
 US                 330        47          33         
 Europe             364        32          4          
 International      687        12          2          
                                                      
 Total              1,381      24          8          
                                                      
 
 
 Turnover         Q1 2015    Q1 2015   
                                                    
                  £m         Reported    Pro-forma  
                             growth      growth     
                             CER%        CER%       
                                                    
 Wellness         593        46          11         
 Oral health      485        9           9          
 Nutrition        182        2           (1)        
 Skin health      121        42          8          
                                                    
 Total            1,381      24          8          
                                                    
                                                      
 
 
 Q1 2015 (£1,381million; up 24%)The Consumer Healthcare business represents the Consumer Healthcare Joint Venture with Novartis together with the GSK Consumer Healthcare businesses in India and Nigeria, which are excluded from the Joint Venture. Turnover grew 24% to £1,381 million, benefiting significantly from the first month's sales of the former Novartis products included in the Joint Venture.  On a pro-forma basis, growth was 8%, primarily reflecting strong growth in the US following the launch of       
 Flonase OTC.  Estimated global market growth was 6% in the quarter versus rolling 12 month growth of 4%.  The uptick was primarily driven by a strong seasonal demand for cold and flu products, and OTC switches in the US market.  Sales from new GSK innovations (product introductions within the last three years on a rolling basis) represented approximately 15% of Q1 2015 sales.  This reflected a particularly strong contribution in the quarter from the Flonase launch in the US and consequently is several      
 points higher than annualised expectations.  Other 2015 launches to date include Fenbid Chewable in China, Sensodyne Repair and Protect Whitening in the US and Germany, and the roll out of Sensodyne Mouthwash. US sales grew 47% on a reported basis to £330 million, and 33% on a pro-forma basis.  Flonase was the region's primary growth driver and the brand currently holds an 11% estimated market share after only 10 weeks.  Oral health sales were driven by Sensodyne which continued its strong performance with 
 growth of 14% and approximately a one percentage point of share gain in the quarter, helped by the launch of Sensodyne Repair and Protect Whitening.  Skin health delivered strong growth helped by 27% growth of Abreva, boosted by stocking patterns.  Niquitin Minis and alli returned to the market but Tums supply has seen some disruption during the quarter. Sales in Europe grew 32% on a reported basis to £364 million and grew 4% pro-forma.  Oral health products reported growth of 8%, reflecting strong         
 performances from both Sensodyne and Aquafresh following an improved supply position, new advertising in key markets, and the roll out of Sensodyne True White in the UK, Sensodyne Repair and Protect in Germany, and Sensodyne Mouthwash across a number of markets.  On a pro-forma basis, Wellness registered mid single digit growth, as regional Respiratory brands Beechams and Coldrex benefited from the stronger cold and flu season.  Nutrition and Skin health sales both declined reflecting disruption from       
 stocking patterns and some supply shortages. International sales of £687 million grew 12% on a reported basis and 2% pro-forma.  China, India and Turkey all reported double digit pro-forma growth, and Oral health (+12%) and Skin health (+11%) performed well across the region.  Wellness growth was impacted by a decline in Panadol sales.  This was primarily due to a challenging competitive environment in Australia and a tough comparative quarter in Latin America as the brand annualised against prior year     
 growth of over 50% following supply improvements.  In Nutrition, Horlicks was up 4%, with strong consumption growth in India partly offset by some retailer destocking in the quarter.                                                                                                                                                                                                                                                                                                                                          
 
 
 Sales from new Pharmaceutical, ViiV Healthcare and Vaccine launches  
 
 
                                                  Q1 2015  
                                                           
                                                             £m     Growth  
                                                                    CER%    
                                                                            
 Global Pharmaceuticals                                                     
 Respiratory             Relvar/Breo Ellipta                 41     >100    
                         Anoro Ellipta                       12     -       
                         Incruse Ellipta                     1      -       
                                                                            
 CVMU                    Eperzan/Tanzeum                     4      -       
                                                                            
 Immuno-inflammation     Benlysta                            51     23      
                                                                            
 Other pharmaceuticals   Potiga/Trobalt                      1      -       
                                                                            
 ViiV Healthcare         Tivicay                             112    >100    
                         Triumeq                             81     -       
                                                                            
                                                             303    >100    
                                                                            
 
 
 New products are those launched in the last five years (2011 to 2015 inclusive).  Sales of new products were £303 million, grew in excess of 100% in the quarter and represented 7% of Global Pharmaceutical, ViiV Healthcare and Vaccine turnover.  
 
 
 Research and development  
 
 
 GSK remains focused on delivering an improved return on its investment in R&D.  Sales contribution, reduced attrition and cost reduction are all important drivers of an improving internal rate of return.  R&D expenditure is not determined as a percentage of sales but instead capital is allocated using strict returns based criteria depending on the pipeline opportunities available. The operations of Pharmaceuticals R&D are broadly split into Discovery activities (up to the completion of phase IIa trials) and 
 Development work (from phase IIb onwards) each supported by specific and common infrastructure and other shared services where appropriate.  R&D expenditure for Q1 2015 is analysed below.                                                                                                                                                                                                                                                                                                                                     
 
 
                                                   Q1 2015    Q1 2014  
                                                   £m         £m       
                                                                       
 Discovery                                         188        170      
 Development                                       314        333      
 Facilities and central support functions          108        124      
                                                                       
 Pharmaceuticals R&D                               610        627      
 Vaccines                                          124        119      
 Consumer Healthcare                               55         38       
                                                                       
 Core R&D                                          789        784      
 Amortisation and impairment of intangible assets  34         56       
 Major restructuring costs                         32         4        
 Acquisition accounting and other                  12         15       
                                                                       
 Total R&D                                         867        859      
                                                                       
 
 
 GSK's Phase III/Registration Pharmaceuticals and Vaccines pipeline                                                                                                                                                                                                                                                                                                                                                                                                                                              
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 The table below is provided as part of our quarterly update to show events and changes to the late-stage pipeline during the quarter and up to the date of this announcement.  There were several news events for late-stage pipeline assets in this quarter and these are listed in the table below.  The Oncology products and Nimenrix have been removed from the table following the completion of the deal with Novartis.  Retosiban has been added to the table as it entered Ph III during the quarter.  
 
 
 Since Q4 2014 results, the following pipeline milestones have been achieved:  
                                                                                                                                                                                                                   
 ·                                                                             Announced positive Overall Survival results from Ph III COMBI-d study of Tafinlar and Mekinist combination in metastatic melanoma;  
 ·                                                                             Announced start of second Ph III (FULFIL) study for once daily closed triple ICS/LABA/LAMA vs Symbicort in patients with COPD;      
 ·                                                                             Announced start of Ph III study for retosiban in spontaneous pre-term labour;                                                       
 ·                                                                             FDA AdCom recommended US approval of Breo Ellipta in adult patients with asthma;                                                    
 ·                                                                             Triumeq approved in Japan for HIV;                                                                                                  
 ·                                                                             Encruse Ellipta approved in Japan for COPD;                                                                                         
 ·                                                                             Synflorix approved in Japan for invasive pneumococcal disease;                                                                      
 ·                                                                             Duac approved in Japan for acne vulgaris;                                                                                           
 ·                                                                             US approval of Flolan reformulation;                                                                                                
 ·                                                                             Three year Ph III data for Mosquirix RTS,S malaria vaccine published in The Lancet;                                                 
 ·                                                                             Publication of full data from ZOE-50 Ph III study of Zoster vaccine in NEJM;                                                        
 ·                                                                             US approval of Breo Ellipta for adult patients with asthma;                                                                         
 ·                                                                             EU filing of ex-vivo stem cell gene therapy for ADA-SCID.                                                                           
 
 
 Respiratory                              US                                                                EU                  News update in the quarter  
 Relvar/Breo Ellipta(FF/VI)               Asthma                                                            ApprovedApril 2015  ApprovedNov 2013            Approved by FDA for adult asthma in US on 30 April 2015       
 vilanterol (VI)                          COPD                                                              Ph III              Ph III                                                                                    
 mepolizumab                              Severe eosinophilic asthma                                        FiledNov 2014       FiledNov 2014                                                                             
 COPD                                     Ph III                                                            Ph III                                          
 FF+UMEC+VI                               COPD                                                              Ph III              Ph III                      Start of FULFIL Ph III study vs Symbicort on 9 February 2015  
 Vaccines                                 US                                                                EU                  News update in the quarter  
 MAGE-A3                                  Melanoma                                                          Ph III              Ph III                                                                                    
 HZ/su herpes zoster                      Shingles prophylaxis                                              Ph III              Ph III                      ZOE-50 data published in NEJM on 28 April 2015                
 Mosquirix (RTS,S)                        Malaria prophylaxis                                               n/a                 FiledJuly 2014              Ph III data published in The Lancet on 24 April 2015          
 Cardiovascular & Metabolic               US                                                                EU                  News update in the quarter  
 losmapimod                               Acute coronary syndrome (ACS)                                     Ph III              Ph III                                                                                    
 retosiban                                Spontaneous pre-term labour                                       Ph III              Ph III                      Start of Ph III study on 17 March 2015                        
 Immuno-inflammation                      US                                                                EU                  News update in the quarter  
 Benlysta (s.c.)                          Systemic lupus erythematosus                                      Ph III              Ph III                                                                                    
 Benlysta (i.v.)                          vasculitis                                                        Ph III              Ph III                                                                                    
 sirukumab                                Rheumatoid arthritis                                              Ph III              Ph III                                                                                    
 Rare diseases                            US                                                                EU                  News update in the quarter  
 2696273(Ex-vivo stem cell gene therapy)  Adenosine deaminase severe combined immune deficiency (ADA-SCID)  Ph II/III           FiledMay 2015               Filed in EU on 5 May 2015                                     
 mepolizumab                              Eosinophilic granulomatosis with polyangiitis (EGPA)              Ph III              Ph III                                                                                    
 Infectious Diseases                      US                                                                EU                  News update in the quarter  
 tafenoquine                              Treatment and relapse prevention of Plasmodium vivax malaria      Ph III              n/a                                                                                       
 Dermatology                              US                                                                EU                  News update in the quarter  
 ofatumumab (s.c.)                        Pemphigus vulgaris                                                Ph III              Ph III                                                                                    
 
 
 Definitions  
 
 
 Core resultsCore results exclude the following items from total results: amortisation and impairment of intangible assets (excluding computer software) and goodwill; major restructuring costs, including those costs following material acquisitions; legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations; other operating income other than royalty income; disposals of associates, products and businesses, and acquisition accounting adjustments for  
 material acquisitions, together with the tax effects of all of these items.  GSK believes this approach provides a clearer view of the underlying performance of the core business and should make the Group's results more comparable with the majority of its peers. CER growthIn order to illustrate underlying performance, it is the Group's practice to discuss its results in terms of constant exchange rate (CER) growth.  This represents growth calculated as if the exchange rates used to determine the results of 
 overseas companies in Sterling had remained unchanged from those used in the comparative period.  All commentaries are presented in terms of CER growth, unless otherwise stated. Pro-forma growthThe Novartis transaction completed on 2 March 2015 and so GSK's reported results include one month of results of the former Novartis Vaccines and Consumer Healthcare businesses and exclude the results of the former GSK Oncology products from 2 March.  Pro-forma growth rates are calculated comparing reported turnover 
 for Q1 2015 with the turnover for Q1 2014 adjusted to include the equivalent one month of results of the former Novartis Vaccines and Consumer Healthcare businesses and to exclude the results of the former GSK Oncology products from 2 March 2014. Full-year 2014 pro-forma resultsPro-forma results for the full-year 2014, where provided, include the following major adjustments: (i) the exclusion of Oncology, (ii) the inclusion of 12 months of the acquired Novartis Consumer and Vaccines businesses, (iii)       
 reallocation of most corporate costs to more accurately reflect the profitability of each segment and (iv) the reallocation of divestments required to Corporate and other unallocated costs.  Pro-forma 2014 Corporate and other unallocated operating profit includes a structural benefit of £219 million realised in Q3 2014.  See "Cautionary statement regarding unaudited pro-forma financial information" below. Free cash flowFree cash flow is the net cash inflow from operating activities less capital expenditure, 
 interest and dividends paid to non-controlling interests plus proceeds from the sale of property, plant and equipment and dividends received from joint ventures and associated undertakings.  It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies.  Free cash flow growth is calculated on a reported basis. Adjusted free cash flowAdjusted free cash flow excludes payments made to settle legal disputes. Free cash flow      
 conversionFree cash flow conversion is free cash flow as a percentage of earnings excluding after-tax legal charges and legal settlements. Adjusted net cash inflow from operating activitiesAdjusted net cash inflow from operating activities excludes payments made to settle legal disputes. Working capital conversion cycleThe working capital conversion cycle is calculated as the number of days sales outstanding plus days inventory outstanding, less days purchases outstanding. Cautionary statement regarding    
 unaudited pro-forma financial informationThe unaudited pro-forma financial information in this release has been prepared to illustrate the effect of (i) the disposal of the oncology assets, (ii) the Consumer Healthcare joint venture (i.e. the acquisition of the Novartis OTC Business), and (iii) the acquisition of the Vaccines business (which excludes the Influenza Vaccines business) on the results of the Group as if they had taken place as at 1 January 2014.   The unaudited pro-forma financial information  
 has been prepared for illustrative purposes only and, by its nature, addresses a hypothetical situation and, therefore, does not represent the Group's actual financial position or results.  The unaudited pro-forma financial does not purport to represent what the Group's financial position actually would have been if the disposal of the Oncology assets, the Consumer Healthcare joint venture and the Vaccines acquisition had been completed on the dates indicated; nor does it purport to represent the financial 
 condition at any future date.  In addition to the matters noted above, the unaudited pro-forma financial information does not reflect the effect of anticipated synergies and efficiencies associated with the Oncology disposal, the Consumer Healthcare joint venture and the Vaccines acquisition. The unaudited pro-forma financial information does not constitute financial statements within the meaning of Section 434 of the Companies Act 2006.  The unaudited pro-forma financial information in this release should 
 be read in conjunction with the financial statements included in (i) the Group's Q1 2015 earnings report dated 6 May 2015 and furnished to the SEC on Form 6-K, (ii) the Group's Annual Report on Form 20-F for 2014 and (iii) the Circular to Shareholders and Notice of General Meeting furnished to the SEC on Form 6-K on 24 November 2014.                                                                                                                                                                                 
 
 
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                              Catherine Hartley  +44 (0) 20 8047 5502  (London)          
                              Sarah Spencer      +44 (0) 20 8047 5502  (London)          
                              Claire Brough      +44 (0) 20 8047 5502  (London)          
                                                                                         
 US Media enquiries:          Stephen Rea        +1 215 751 4394       (Philadelphia)    
                              Mary Anne Rhyne    +1 919 483 0492       (North Carolina)  
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                              Melinda Stubbee    +1 919 483 2510       (North Carolina)  
                              Jenni Ligday       +1 202 715 1049       (Washington)      
                              Karen Hagens       +1 919 483 2863       (North Carolina)  
                                                                                         
 Analyst/Investor enquiries:  Ziba Shamsi        +44 (0) 20 8047 5543  (London)          
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 Registered in England & Wales:No. 3888792                         
                                                                   
 Registered Office:980 Great West RoadBrentford, MiddlesexTW8 9GS  
 
 
 Financial information  
 
 
 Income statement  
 
 
                                                              Q1 2015    Q1 2014  
                                                              £m         £m       
                                                                                  
 TURNOVER                                                     5,622      5,613    
                                                                                  
 Cost of sales                                                (2,103)    (1,743)  
                                                                                  
 Gross profit                                                 3,519      3,870    
                                                                                  
 Selling, general and administration                          (2,225)    (1,971)  
 Research and development                                     (867)      (859)    
 Royalty income                                               77         70       
 Other operating income/(expense)                             8,712      (44)     
                                                                                  
 OPERATING PROFIT                                             9,216      1,066    
                                                                                  
 Finance income                                               32         18       
 Finance expense                                              (191)      (182)    
 Profit on disposal of associates                             843        -        
 Share of after tax profits of associates and joint ventures  23         1        
                                                                                  
 PROFIT BEFORE TAXATION                                       9,923      903      
                                                                                  
 Taxation                                                     (1,885)    (184)    
 Tax rate %                                                   19.0%      20.4%    
                                                                                  
 PROFIT AFTER TAXATION FOR THE PERIOD                         8,038      719      
                                                                                  
                                                                                  
 (Loss)/profit attributable to non-controlling interests      (51)       51       
 Profit attributable to shareholders                          8,089      668      
                                                                                  
                                                              8,038      719      
                                                                                  
                                                                                  
 EARNINGS PER SHARE                                           167.8p     13.9p    
                                                                                  
                                                                                  
 Diluted earnings per share                                   166.4p     13.7p    
                                                                                  
 
 
 Statement of comprehensive income  
 
 
                                                                              Q1 2015    Q1 2014  
                                                                              £m         £m       
                                                                                                  
 Profit for the period                                                        8,038      719      
                                                                                                  
 Items that may be reclassified subsequently to income statement:                                 
 Exchange movements on overseas net assets and net investment hedges          (332)      (17)     
 Fair value movements on available-for-sale investments                       241        (30)     
 Reclassification of fair value movements on available-for-sale investments   (262)      (1)      
 Deferred tax on fair value movements on available-for-sale investments       (24)       (19)     
 Deferred tax reversed on reclassification of available-for-sale investments  2          -        
 Fair value movements on cash flow hedges                                     (6)        (1)      
 Deferred tax on fair value movements on cash flow hedges                     1          -        
 Reclassification of cash flow hedges to income statement                     3          2        
 Share of other comprehensive expense of associates and joint ventures        (77)       13       
                                                                                                  
                                                                              (454)      (53)     
                                                                                                  
 Items that will not be reclassified to income statement:                                         
 Exchange movements on overseas net assets of non-controlling interests       20         5        
 Remeasurement losses on defined benefit plans                                (328)      (177)    
 Deferred tax on remeasurement losses on defined benefit plans                75         42       
                                                                                                  
                                                                              (233)      (130)    
                                                                                                  
 Other comprehensive expense for the period                                   (687)      (183)    
                                                                                                  
 Total comprehensive income for the period                                    7,351      536      
                                                                                                  
                                                                                                  
 Total comprehensive income for the period attributable to:                                       
 Shareholders                                                                 7,382      480      
 Non-controlling interests                                                    (31)       56       
                                                                                                  
                                                                              7,351      536      
                                                                                                  
 
 
 Global Pharmaceuticals, ViiV Healthcare and Vaccines turnover  
 Three months ended 31 March 2015                               
 
 
                                               Total    US        Europe    International  
                                                                                                                                 
                                               £m       Growth    £m        Growth           £m       Growth    £m       Growth  
                                                        CER%                CER%                      CER%               CER%    
                                                                                                                                 
 Respiratory                                   1,408    (9)       583       (22)             392      (4)       433      5       
 Anoro Ellipta                                 12       -         9         -                2        -         1        -       
 Avamys/Veramyst                               71       7         6         (25)             17       6         48       14      
 Flixotide/Flovent                             153      (22)      83        (38)             27       (3)       43       15      
 Relvar/Breo Ellipta                           41       >100      14        >100             16       >100      11       >100    
 Seretide/Advair                               898      (14)      392       (21)             291      (11)      215      (4)     
 Ventolin                                      161      (9)       78        (24)             32       6         51       11      
 Other                                         72       5         1         -                7        -         64       4       
                                                                                                                                 
 Cardiovascular, metabolic and urology (CVMU)  218      (8)       83        (8)              68       (9)       67       (8)     
 Avodart                                       179      (7)       56        (14)             66       3         57       (12)    
 Other                                         39       (14)      27        4                2        (90)      10       22      
                                                                                                                                 
 Immuno-inflammation                           60       19        55        21               4        33        1        (50)    
 Benlysta                                      51       23        46        26               4        33        1        (50)    
 Other                                         9        -         9         -                -        -         -        -       
                                                                                                                                 
 Oncology                                      216      (18)      93        (22)             70       (20)      53       (5)     
                                                                                                                                 
 Other pharmaceuticals                         525      (9)       42        (17)             149      1         334      (12)    
 Dermatology                                   109      (11)      12        (15)             37       (5)       60       (14)    
 Augmentin                                     140      (3)       -         (100)            51       (3)       89       (2)     
 Other anti-bacterials                         47       (16)      1         -                16       (14)      30       (17)    
 Rare diseases                                 91       (10)      12        (54)             32       6         47       -       
 Other                                         138      (9)       17        >100             13       60        108      (21)    
                                                                                                                                 
 Innovative Pharmaceuticals                    2,427    (9)       856       (18)             683      (5)       888      (4)     
                                                                                                                                 
 Established Products                          650      (20)      163       (42)             132      (14)      355      (8)     
 Coreg                                         27       (22)      27        (22)             -        -         -        -       
 Hepsera                                       22       (9)       -         -                -        -         22       (9)     
 Imigran/Imitrex                               38       (15)      18        (29)             13       (7)       7        14      
 Lamictal                                      127      (2)       63        -                23       (11)      41       2       
 Lovaza                                        28       (75)      28        (75)             -        -         -        -       
 Requip                                        22       (14)      1         (67)             7        (18)      14       -       
 Serevent                                      23       (15)      10        -                10       (23)   

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