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REG - GlaxoSmithKline PLC - Final Results <Origin Href="QuoteRef">GSK.L</Origin> - Part 4

- Part 4: For the preceding part double click  ID:nRSH3433Wc 

                                                                                                                                     
 daprodustat (1278863) (Prolyl hydroxylase inhibitor)                                                                                                                            Wound healing                                                                                                  Ph I                                  
 daprodustat (1278863) (Prolyl hydroxylase inhibitor)                                                                                                                            Anaemia associated with chronic renal disease                                                                  Ph III                                
 
 
 1  Option-based alliance with Ionis Pharmaceuticals                                  
 2  Option-based alliance with Adaptimmune Ltd.                                       
 3  Option-based alliance with OncoMed Pharmaceuticals                                
 4  Option-based alliance with Telethon and Ospedale San Raffaele                     
 *  The name Shingrix has not yet been approved for use  by any regulatory authority  
 
 
 The full version of the GSK product development pipeline chart with all clinical assets in Phase I to Phase III can be found at: https://gsk.com/media/1017505/product-pipeline-march-2016.pdf  
 
 
 Definitions  
 
 
 Core resultsTotal reported results represent the Group's overall performance.  However, these results can contain material unusual or non-operational items that may obscure the key trends and factors determining the Group's operational performance.  As a result, GSK also reports core results. Core results exclude the following items from total results: amortisation and impairment of intangible assets (excluding computer software) and goodwill; major restructuring costs, including those costs following      
 material acquisitions; legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations, transaction-related accounting adjustments for significant acquisitions, and other items, including disposals of associates, products and businesses and other operating income other than royalty income, together with the tax effects of all of these items.  These items are excluded from core results either because their impact can be significant and volatile or       
 because their exclusion improves comparabilities and consistency of reporting with the majority of our peer companies. Core results reporting is utilised as one of the bases for internal performance reporting alongside total results, cash flow generation and a number other metrics.  Core results are presented and discussed in this Results Announcement as GSK believes that core results are more representative of the performance of the Group's operations and allow the key trends and factors driving that      
 performance to be more easily and clearly identified by shareholders.  The definition of core results, as set out above, also aligns the Group's results more closely with the majority of our peer companies and how they report earnings. Reconciliations between total and core results, as set out on pages 12 and 57 to 60, including detailed breakdowns of the key non-core items, are provided to shareholders to ensure greater visibility and transparency as they assess the Group's performance. CER growthIn order 
 to illustrate underlying performance, it is the Group's practice to discuss its results in terms of constant exchange rate (CER) growth.  This represents growth calculated as if the exchange rates used to determine the results of overseas companies in Sterling had remained unchanged from those used in the comparative period.  All commentaries are presented in terms of CER growth, unless otherwise stated. Pro-forma growth ratesThe Novartis transaction completed on 2 March 2015 and so GSK's reported results  
 include the results of the former Novartis Vaccines and Consumer Healthcare businesses and exclude the results of the former GSK Oncology business, both from 2 March 2015.  For the Vaccines and Consumer Healthcare segments, pro-forma growth rates are calculated comparing reported turnover and core operating profits for the year ended December 2016 with the turnover and operating profit for the year ended December 2015 adjusted to include the two months of sales of the former Novartis Vaccines and Consumer  
 Healthcare products, respectively.  For the Pharmaceuticals segment, the turnover and operating profit for the year ended December 2015 is adjusted to exclude the two months of sales of the former GSK Oncology business for January and February 2015. Free cash flowFree cash flow is the net cash inflow from operating activities less capital expenditure, interest and dividends paid to non-controlling interests plus proceeds from the sale of property, plant and equipment and dividends received from joint       
 ventures, associated undertakings and equity investments.  It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies.  Free cash flow growth is calculated on a reported basis.  A reconciliation of net cash inflow from operations to free cash flow is presented on page 54. Adjusted free cash flowAdjusted free cash flow excludes payments made to settle legal disputes.  Such payments could fluctuate significantly between    
 reporting periods and removing them allows the trends in free cash flow to be more easily identified by shareholders.  Free cash flow conversionFree cash flow conversion is free cash flow as a percentage of earnings excluding after-tax legal charges and legal settlements. Adjusted net cash inflow from operating activitiesAdjusted net cash inflow from operating activities excludes payments made to settle legal disputes.  Such payments could fluctuate significantly between reporting periods and removing them 
 allows the trends in net cash inflow from operating activities to be more easily identified by shareholders. Working capital conversion cycleThe working capital conversion cycle is calculated as the number of days sales outstanding plus days inventory outstanding, less days purchases outstanding.                                                                                                                                                                                                                       
 
 
 Brand names and partner acknowledgementsBrand names appearing in italics throughout this document are trademarks of GSK or associated companies or used under licence by the Group.  
 
 
 Outlook assumptions and cautionary statements  
 
 
 Assumptions related to 2017 guidance and 2016-2020 outlookIn outlining the expectations for 2017 and the five-year period 2016-2020, the Group has made certain assumptions about the healthcare sector, the different markets in which the Group operates and the delivery of revenues and financial benefits from its current portfolio, pipeline and restructuring programmes. For the Group specifically, over the period to 2020 GSK expects further declines in sales of Seretide/Advair.  The introduction of a generic  
 alternative to Advair in the US has been factored into the Group's assessment of its future performance.  The Group assumes no premature loss of exclusivity for other key products over the period.  The Group's expectation of at least £6 billion of revenues per annum on a CER basis by 2020 from the New Pharmaceutical and Vaccine products listed on page 31 includes contributions from the current pipeline asset Shingrix.  This target is now expected to be met up to two years earlier.  The Group also expects   
 volume demand for its products to increase, particularly in Emerging Markets.  The assumptions for the Group's revenue and earnings expectations assume no material interruptions to supply of the Group's products and no material mergers, acquisitions, disposals, litigation costs or share repurchases for the Company; and no change in the Group's shareholdings in ViiV Healthcare or Consumer Healthcare.  They also assume no material changes in the macro-economic and healthcare environment. The Group's          
 expectations assume successful delivery of the Group's integration and restructuring plans over the period 2016-2020.  Material costs for investment in new product launches and R&D have been factored into the expectations given.  The expectations are given on a constant currency basis and assume no material change to the Group's effective tax rate or the tax regulatory environment in which it operates.                                                                                                           
 
 
 Assumptions and cautionary statement regarding forward-looking statementsThe Group's management believes that the assumptions outlined above are reasonable, and that the aspirational targets described in this report are achievable based on those assumptions.  However, given the longer term nature of these expectations and targets, they are subject to greater uncertainty, including potential material impacts if the above assumptions are not realised, and other material impacts related to foreign exchange    
 fluctuations, macro-economic activity, changes in regulation, government actions or intellectual property protection, actions by our competitors, and other risks inherent to the industries in which we operate. This document contains statements that are, or may be deemed to be, "forward-looking statements".  Forward-looking statements give the Group's current expectations or forecasts of future events.  An investor can identify these statements by the fact that they do not relate strictly to historical or   
 current facts.  They use words such as 'anticipate', 'estimate', 'expect', 'intend', 'will', 'project', 'plan', 'believe', 'target' and other words and terms of similar meaning in connection with any discussion of future operating or financial performance.  In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal         
 proceedings, and financial results.  Other than in accordance with its legal or regulatory obligations (including under the UK Listing Rules and the Disclosure and Transparency Rules of the Financial Conduct Authority), the Group undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.  The reader should, however, consult any additional disclosures that the Group may make in any documents which it publishes and/or files with the  
 US Securities and Exchange Commission (SEC).  All readers, wherever located, should take note of these disclosures.  Accordingly, no assurance can be given that any particular expectation will be met and investors are cautioned not to place undue reliance on the forward-looking statements. Forward-looking statements are subject to assumptions, inherent risks and uncertainties, many of which relate to factors that are beyond the Group's control or precise estimate.  The Group cautions investors that a number 
 of important factors, including those in this document, could cause actual results to differ materially from those expressed or implied in any forward-looking statement.  Such factors include, but are not limited to, those discussed under Item 3.D 'Risk factors' in the Group's Annual Report on Form 20-F for 2015 and those discussed in Part 2 of the Circular to Shareholders and Notice of General Meeting furnished to the SEC on Form 6-K on 24 November 2014.  Any forward looking statements made by or on behalf 
 of the Group speak only as of the date they are made and are based upon the knowledge and information available to the Directors on the date of this report.                                                                                                                                                                                                                                                                                                                                                                    
 
 
 Cautionary statement regarding unaudited pro-forma financial informationThe unaudited pro-forma financial information in this release has been prepared to illustrate the effect of (i) the disposal of the Oncology business, (ii) the Consumer Healthcare Joint Venture (i.e. the acquisition of the Novartis OTC Business), and (iii) the acquisition of the Vaccines business (which excludes the Novartis influenza vaccines business) on the results of the Group as if they had taken place as at 1 January 2015. The    
 unaudited pro-forma financial information has been prepared for illustrative purposes only and, by its nature, addresses a hypothetical situation and, therefore, does not represent the Group's actual financial position or results.  The unaudited pro-forma financial information does not purport to represent what the Group's financial position actually would have been if the disposal of the Oncology business, the Consumer Healthcare Joint Venture and the Vaccines acquisition had been completed on the dates   
 indicated; nor does it purport to represent the financial condition at any future date.  In addition to the matters noted above, the unaudited pro-forma financial information does not reflect the effect of anticipated synergies and efficiencies associated with the Oncology disposal, the Consumer Healthcare Joint Venture and the Vaccines acquisition. The unaudited pro-forma financial information does not constitute financial statements within the meaning of Section 434 of the Companies Act 2006.  The        
 unaudited pro-forma financial information in this release should be read in conjunction with the financial statements included in (i) the Group's Q4 2016 results announcement dated 8 February 2017 and furnished to the SEC on Form 6-K, (ii) the Group's Annual Report on Form 20-F for 2015 and (iii) the Circular to Shareholders and Notice of General Meeting furnished to the SEC on Form 6-K on 24 November 2014.                                                                                                      
 
 
 Contacts  
 
 
 GSK - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer.  For further information please visit www.gsk.com.  
 
 
www.gsk.com 
 
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 GSK enquiries:                                                                       
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 Registered in England & Wales:No. 3888792                         
                                                                   
 Registered Office:980 Great West RoadBrentford, MiddlesexTW8 9GS  
 
 
 Financial information  
 
 
 Income statements  
 
 
                                                                         2016£m     2015£m     Q4 2016£m    Q4 2015£m  
                                                                                                                       
 TURNOVER                                                                27,889     23,923     7,586        6,286      
                                                                                                                       
 Cost of sales                                                           (9,290)    (8,853)    (2,508)      (2,541)    
                                                                                                                       
 Gross profit                                                            18,599     15,070     5,078        3,745      
                                                                                                                       
 Selling, general and administration                                     (9,366)    (9,232)    (2,711)      (2,498)    
 Research and development                                                (3,628)    (3,560)    (1,003)      (1,054)    
 Royalty income                                                          398        329        117          91         
 Other operating income/(expense)                                        (3,405)    7,715      (886)        (538)      
                                                                                                                       
 OPERATING PROFIT/(LOSS)                                                 2,598      10,322     595          (254)      
                                                                                                                       
 Finance income                                                          72         104        20           41         
 Finance expense                                                         (736)      (757)      (193)        (199)      
 Profit on disposal of associates                                        -          843        -            1          
 Share of after tax profits/(losses) of associates   and joint ventures  5          14         1            (5)        
                                                                                                                       
 PROFIT/(LOSS) BEFORE TAXATION                                           1,939      10,526     423          (416)      
                                                                                                                       
 Taxation                                                                (877)      (2,154)    (106)        (12)       
 Tax rate %                                                              45.2%      20.5%      25.1%        (2.9)%     
                                                                                                                       
 PROFIT/(LOSS) AFTER TAXATION FOR   THE PERIOD                           1,062      8,372      317          (428)      
                                                                                                                       
                                                                                                                       
 Profit/(loss) attributable to non-controlling interests                 150        (50)       60           (74)       
 Profit/(loss) attributable to shareholders                              912        8,422      257          (354)      
                                                                                                                       
                                                                         1,062      8,372      317          (428)      
                                                                                                                       
                                                                                                                       
 EARNINGS/(LOSS) PER SHARE                                               18.8p      174.3p     5.3p         (7.3)p     
                                                                                                                       
                                                                                                                       
 Diluted earnings/(loss) per share                                       18.6p      172.3p     5.2p         (7.3)p     
                                                                                                                       
 
 
 Statement of comprehensive income  
 
 
                                                                              2016£m    2015£m  
                                                                                                
 Profit for the year                                                          1,062     8,372   
                                                                                                
 Items that may be reclassified subsequently to income statement:                               
 Exchange movements on overseas net assets and net investment hedges          646       (618)   
 Fair value movements on available-for-sale investments                       251       416     
 Reclassification of fair value movements on available-for-sale investments   (245)     (346)   
 Deferred tax on fair value movements on available-for-sale investments       -         (91)    
 Deferred tax reversed on reclassification of available-for-sale investments  51        36      
 Fair value movements on cash flow hedges                                     2         2       
 Deferred tax on fair value movements on cash flow hedges                     2         -       
 Reclassification of cash flow hedges to income statement                     1         2       
 Share of other comprehensive expense of associates and joint ventures        -         (77)    
                                                                                                
                                                                              708       (676)   
                                                                                                
 Items that will not be reclassified to income statement:                                       
 Exchange movements on overseas net assets of non-controlling interests       603       8       
 Re-measurement (losses)/gains on defined benefit plans                       (475)     261     
 Tax on re-measurement of defined benefit plans                               126       (80)    
                                                                                                
                                                                              254       189     
                                                                                                
 Other comprehensive income/(expense) for the year                            962       (487)   
                                                                                                
 Total comprehensive income for the year                                      2,024     7,885   
                                                                                                
                                                                                                
 Total comprehensive income for the year attributable to:                                       
 Shareholders                                                                 1,271     7,927   
 Non-controlling interests                                                    753       (42)    
                                                                                                
                                                                              2,024     7,885   
                                                                                                
 
 
 Statement of comprehensive income  
 
 
                                                                              Q4 2016£m    Q4 2015£m  
                                                                                                      
 Profit/(loss) for the period                                                 317          (428)      
                                                                                                      
 Items that may be reclassified subsequently to income statement:                                     
 Exchange movements on overseas net assets and net investment hedges          (347)        (129)      
 Fair value movements on available-for-sale investments                       8            341        
 Reclassification of fair value movements on available-for-sale investments   5            (6)        
 Deferred tax on fair value movements on available-for-sale investments       (9)          (18)       
 Deferred tax reversed on reclassification of available-for-sale investments  1            6          
 Fair value movements on cash flow hedges                                     (10)         3          
 Deferred tax on fair value movements on cash flow hedges                     2            -          
 Reclassification of cash flow hedges to income statement                     12           (2)        
                                                                                                      
                                                                              (338)        195        
                                                                                                      
 Items that will not be reclassified to income statement:                                             
 Exchange movements on overseas net assets of non-controlling interests       48           9          
 Re-measurement gains on defined benefit plans                                744          649        
 Tax on re-measurement of defined benefit plans                               (129)        (156)      
                                                                                                      
                                                                              663          502        
                                                                                                      
 Other comprehensive income for the period                                    325          697        
                                                                                                      
 Total comprehensive income for the period                                    642          269        
                                                                                                      
                                                                                                      
 Total comprehensive income for the period attributable to:                                           
 Shareholders                                                                 534          334        
 Non-controlling interests                                                    108          (65)       
                                                                                                      
                                                                              642          269        
                                                                                                      
 
 
 Pharmaceuticals turnover - year ended 31 December 2016  
 
 
                                              Total     US            Europe    International  
                                                                                                                                             
                                              £m        GrowthCER%    £m        GrowthCER%       £m       GrowthCER%    £m       GrowthCER%  
                                                                                                                                             
 Respiratory                                  6,510     2             3,306     7                1,383    (10)          1,821    3           
 Anoro Ellipta                                201       >100          139       >100             39       >100          23       >100        
 Arnuity Ellipta                              15        >100          14        >100             -        -             1        (100)       
 Avamys/Veramyst                              277       8             25        (12)             74       2             178      15          
 Flixotide/Flovent                            637       (8)           378       (11)             94       (8)           165      -           
 Incruse Ellipta                              114       >100          86        >100             23       >100          5        >100        
 Nucala                                       102       >100          71        >100             23       >100          8        -           
 Relvar/Breo Ellipta                          620       >100          344       >100             140      60            136      67          
 Seretide/Advair                              3,485     (15)          1,829     (13)             835      (24)          821      (7)         
 Ventolin                                     785       15            421       23               127      1             237      12          
 Other                                        274       (1)           (1)       (100)            28       (3)           247      (2)         
                                                                                                                                             
 Cardiovascular, metabolicand urology (CVMU)  860       (11)          288       (18)             323      12            249      (23)        
 Avodart                                      635       (14)          70        (63)             317      13            248      (8)         
 Eperzan/Tanzeum                              121       >100          118       >100             3        100           -        -           
 Other                                        104       (42)          100       (17)             3        (60)          1        (98)        
                                                                                                                                             
 Immuno-inflammation                          340       15            311       14               21       27            8        17          
 Benlysta                                     306       19            277       18               21       20            8        33          
 Other                                        34        (9)           34        (9)              -        -             -        -           
                                                                                                                                             
 Other pharmaceuticals                        2,297     (14)          98        (69)             627      (13)          1,572    (4)         
 Dermatology                                  393       (12)          16        (63)             146      (2)           231      (9)         
 Augmentin                                    563       -             -         -                177      (5)           386      2           
 Other anti-bacterials                        169       (15)          4         (50)             49       (14)          116      (13)        
 Rare diseases                                423       -             49        (4)              137      2             237      (1)         
 Oncology                                     161       (38)          (1)       (100)            -        -             162      73          
 Other                                        588       (23)          30        (72)             118      2             440      (19)        
                                                                                                                                             
 Established products                         2,541     (8)           702       (3)              513      (4)           1,326    (12)        
 Coreg                                        131       (5)           131       (5)              -        -             -        -           
 Hepsera                                      58        (17)          -         -                -        -             58       (16)        
 Imigran/Imitrex                              177       3             85        8                62       4             30       (11)        
 Lamictal                                     614       5             313       5                106      1             195      9           
 Lovaza                                       43        (59)          43        (59)             -        -             -        -           
 Requip                                       116       8             13        >100             30       (7)           73       3           
 Serevent                                     96        (6)           49        -                35       (11)          12       (14)        
 Seroxat/Paxil                                206       10            15        (100)            40       6             151      (8)         
 Valtrex                                      118       (37)          16        (30)             25       (4)           77       (45)        
 Zeffix                                       111       (24)          2         -                7        (14)          102      (25)        
 Other                                        871       (10)          35        (6)              208      (8)           628      (11)        
                                                                                                                                             
 HIV                                          3,556     37            2,132     46               1,017    29            407      21          
 Combivir                                     23        (38)          3         (75)             6        (35)          14       (16)        
 Epzicom/Kivexa                               568       (27)          195       (32)             251      (25)          122      (21)        
 Lexiva/Telzir                                51        (26)          29        (33)             8        (42)          14       4           
 Selzentry                                    125       (9)           65        (2)              41       (22)          19       4           
 Tivicay                                      953       45            635       46               228      40            90       47          
 Triumeq                                      1,735     >100          1,159     >100             434      >100          142      >100        
 Trizivir                                     16        (42)          5         (54)             10       (35)          1        (42)        
 Other                                        85        33            41        (4)              39       >100          5        (66)        
                                                                                                                                             
 Pharmaceuticals                              16,104    3             6,837     10               3,884    -             5,383    (3)         
                                                                                                                                             
 
 
 Vaccines turnover - year ended 31 December 2016  
 
 
                                   Total    US            Europe    International  
                                                                                                                                 
                                   £m       GrowthCER%    £m        GrowthCER%       £m       GrowthCER%    £m       GrowthCER%  
                                                                                                                                 
 Rotarix                           469      1             129       (17)             75       8             265      10          
 Synflorix                         504      19            -         -                68       59            436      15          
 Fluarix, FluLaval                 414      38            315       42               32       26            67       31          
 Bexsero                           390      >100          122       >100             236      >100          32       >100        
 Menveo                            202      16            121       8                27       (31)          54       >100        
 Boostrix                          470      18            238       1                139      43            93       39          
 Infanrix, Pediarix                769      (5)           338       12               335      (8)           96       (31)        
 Hepatitis                         602      1             294       (4)              197      17            111      (8)         
 Priorix, Priorix Tetra, Varilrix  300      5             -         -                152      -             148      9           
 Cervarix                          81       (14)          1         (67)             33       (22)          47       (4)         
 Other                             391      6             41        (27)             129      19            221      8           
                                                                                                                                 
                                   4,592    14            1,599     13               1,423    18            1,570    10          
                                                                                                                                 
 
 
 Pharmaceuticals turnover - three months ended 31 December 2016  
 
 
                                              Total    US            Europe    International  
                                                                                                                                            
                                              £m       GrowthCER%    £m        GrowthCER%       £m       GrowthCER%    £m       GrowthCER%  
                                                                                                                                            
 Respiratory                                  1,918    2             1,053     5                360      (7)           505      2           
 Anoro Ellipta                                69       100           49        95               13       83            7        >100        
 Arnuity Ellipta                              6        >100          5         >100             -        -             1        >(100)      
 Avamys/Veramyst                              70       6             7         (14)             18       -             45       13          
 Flixotide/Flovent                            190      (4)           115       (8)              27       (4)           48       8           
 Incruse Ellipta                              38       >100          28        >100             8        >100          2        >100        
 Nucala                                       44       >100          30        >100             9        >100          5        -           
 Relvar/Breo Ellipta                          207      77            122       >100             42       52            43       27          
 Seretide/Advair                              975      (20)          556       (21)             201      (24)          218      (11)        
 Ventolin                                     245      43            141       78               36       3             68       20          
 Other                                        74       -             -         -                6        (3)           68       (5)         
                                                                                                                                            
 Cardiovascular, metabolicand urology (CVMU)  234      12            74        48               84       20            76       (15)        
 Avodart                                      164      23            7         >(100)           82       27            75       -           
 Eperzan/Tanzeum                              38       88            37        82               1        >(100)        -        -           
 Other                                        32       (41)          30        (13)             1        (100)         1        (93)        
                                                                                                                                            
 Immuno-inflammation                          112      27            104       27               6        25            2        -           
 Benlysta                                     89       17            81        17               6        -             2        >100        
 Other                                        23       82            23        82               -        -             -        -           
                                                                                                                                            
 Other pharmaceuticals                        636      (12)          31        (43)             169      (13)          436      (8)         
 Dermatology                                  113      (6)           4         (69)             39       -             70       5           
 Augmentin                                    146      -             -         -                49       (4)           97       2           
 Other anti-bacterials                        39       (32)          1         (50)             12       (23)          26       (34)        
 Rare diseases                                117      1             14        20               36       -             67       (2)         
 Oncology & Emesis                            38       >100          (1)       >100             -        -             39       >100        
 Other                                        183      (36)          13        (53)             33       (37)          137      (34)        
                                                                                                                                            
 Established products                         653      (6)           184       -                136      (4)           333      (9)         
 Coreg                                        37       (6)           37        (6)              -        -             -        -           
 Hepsera                                      9        (30)          -         -                -        -             9        (22)        
 Imigran/Imitrex                              49       10            23        44               16       (6)           10       (25)        
 Lamictal                                     167      7             87        4                27       (4)           53       18          
 Lovaza                                       8        (73)          8         (73)             -        -             -        -           
 Requip                                       31       (4)           2         -                8        (22)          21       7           
 Serevent                                     27       (8)           16        -                9        (22)          2        -           
 Seroxat/Paxil                                53       19            1         (100)            10       11            42       -           
 Valtrex                                      31       (24)          4         (25)             6        (17)          21       (25)        
 Zeffix                                       20       (45)          1         >100             2        (50)          17       (48)        
 Other                                        221      (6)           5         >100             58       6             158      (10)        
                                                                                                                                            
 HIV                                          1,022    25            634       32               267      13            121      21          
 Combivir                                     6        (37)          1         (60)             1        (29)          4        (33)        
 Epzicom/Kivexa                               114      (42)          35        (52)             48       (42)          31       (23)        
 Lexiva/Telzir                                11       (23)          7         (34)             2        (46)          2        58          
 Selzentry                                    33       (7)           18        (6)              8        (32)          7        78          
 Tivicay                                      290      42            198       47               63       25            29       51          
 Triumeq                                      530      56            362       57               122      46            46       76          
 Trizivir                                     3        (50)          1         (57)             2        (41)          -        -           
 Other                                        35       >100          12        (7)              21       >100          2        (41)        
                                                                                                                                            
 Pharmaceuticals                              4,575    4             2,080     12               1,022    (1)           1,473    (4)         
                                                                                                                                            
 
 
 Vaccines turnover - three months ended 31 December 2016  
 
 
                          Total    US            Europe    International  
                                                                                                                    
                          £m       GrowthCER%    £m        GrowthCER%       £m     GrowthCER%    £m     GrowthCER%  
                                                                                                                    
 Rotarix                  106      (10)          32        (4)              22     19            52     (22)        
 Synflorix                122      (24)          -         -                33     >100          89     (42)        
 Fluarix, FluLaval        63       (25)          33        (31)             14     20            16     (36)        
 Bexsero                  98       >100          22        >100             66     >100          10     >100        
 Menveo                   50       72            19        (13)             5      (64)          26     >100        
 Boostrix                 127      19            60        (6)              33     >100          34     16          
 Infanrix, Pediarix       219      15            107       64               81     (22)          31     50          
 Hepatitis                157      (1)           76        (7)              48     3             33     12          
 Priorix, Prioruix Tetra  83       (12)          -         -                36     (19)          47     (7)         
 Cervarix                 23       18            -         -                10     (20)          13     71          
 Other                    89       (33)          5         (64)             22     (17)          62     (31)        
                                                                                                                    
                          1,137    -             354       5                370    11            413    (11)        
                                                                                                                    
 
 
 Balance sheet  
 
 
                                                          31 December 2016£m           31 December 2015£m  
 ASSETS                                                                                                    
 Non-current assets                                                                                        
 Property, plant and equipment                            10,808                       9,668               
 Goodwill                                                 5,965                        5,162               
 Other intangible assets                                  18,776                       16,672              
 Investments in associates and joint ventures             263                          207                 
 Other investments                                        985                          1,255               
 Deferred tax assets                                      4,374                        2,905               
 Other non-current assets                                 1,199                        990                 
                                                                                                           
 Total non-current assets                                 42,370                       36,859              
                                                                                                           
 Current assets                                                                                            
 Inventories                                              5,102                        4,716               
 Current tax recoverable                                  226                          180                 
 Trade and other receivables                              6,026                        5,615               
 Derivative financial instruments                         156                          125                 
 Liquid investments                                       89                           75                  
 Cash and cash equivalents                                4,897                        5,830               
 Assets held for sale                                     215                          46                  
                                                                                                           
 Total current assets                                     16,711                       16,587              
                                                                                                           
 TOTAL ASSETS                                             59,081                       53,446              
                                                                                                           
 LIABILITIES                                                                                               
 Current liabilities                                                                                       
 Short-term borrowings                                    (4,129)                      (1,308)             
 Contingent consideration liability                       (561)                        (306)               
 Trade and other payables                                 (11,964)                     (8,885)             
 Derivative financial instruments                         (194)                        (153)               
 Current tax payable                                      (1,305)                      (1,421)             
 Short-term provisions                                    (848)                        (1,344)             
                                                                                                           
 Total current liabilities                                (19,001)                     (13,417)            
                                                                                                           
 Non-current liabilities                                                                                   
 Long-term borrowings                                     (14,661)                     (15,324)            
 Deferred tax liabilities                                 (1,934)                      (1,522)             
 Pensions and other post-employment benefits     (4,090)                      (3,229)  
 Other provisions                                         (652)                        (420)               
 Contingent consideration liability                       (5,335)                      (3,549)             
 Other non-current liabilities                            (8,445)                      (7,107)             
                                                                                                           
 Total non-current liabilities                            (35,117)                     (31,151)            
                                                                                                           
 TOTAL LIABILITIES                                        (54,118)                     (44,568)            
                                                                                                           
 NET ASSETS                                               4,963                        8,878               
                                                                                                           
 EQUITY                                                                                                    
 Share capital                                            1,342                        1,340               
 Share premium account                                    2,954                        2,831               
 Retained earnings                                        (5,392)                      (1,397)             
 Other reserves                                           2,220                        2,340               
                                                                                                           
 Shareholders' equity                                     1,124                        5,114               
                                                                                                           
 Non-controlling interests                                3,839                        3,764               
                                                                                                           
 TOTAL EQUITY                                             4,963                        8,878               
                                                                                                           
 
 
 Statement of changes in equity  
 
 
                                                                 Sharecapital£m  Sharepremium£m  Retainedearnings£m  Otherreserves£m  Share-holder'sequity£m  Non-controllinginterests£m  Totalequity£m  
                                                                 ------------    ------------    ------------        ------------     ------------            ------------                ------------   
                                                                                                                                                                                                         
 At 1 January 2016                                               1,340           2,831           (1,397)             2,340            5,114                   3,764                       8,878          
                                                                                                                                                                                                         
 Profit for the year                                                                             912                                  912                     150                         1,062          
 Other comprehensive income for the year                                                         284                 75               359                     603                         962            
                                                                                                 ------------        ------------     ------------            ------------                ------------   
 Total comprehensive income for the year                                                         1,196               75               1,271                   753                         2,024          
                                                                                                 ------------        ------------     ------------            ------------                ------------   
 Distributions to non-controlling interests                                                                                                                   (534)                       (534)          
 Dividends to shareholders                                                                       (4,850)                              (4,850)                                             (4,850)        
 Recognition of liabilities with non-controlling   interests                                     (2,013)                              (2,013)                 (159)                       (2,172)        
 De-recognition of liabilities with non-controlling   interests                                  1,244                                1,244                                               1,244          
 Changes in non-controlling interests                                                            17                                   17                      15                          32             
 Shares issued                                                   2               87                                                   89                                                  89             
 Shares acquired by ESOP Trusts                                                  36              466                 (576)            (74)                                                (74)           
 Write-down on shares held by ESOP Trusts                                                        (381)               381                                                                  -              
 Share-based incentive plans                                                                     319                                  319                                                 319            
 Tax on share-based incentive plans                                                              7                                    7                                                   7              
                                                                 ------------    

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