RCS - Oxford Nanopore Tech - Oxford Nanopore announces technology updates

Oxford Nanopore TechnologiesAnnouncement

02/12/2021 07:00

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RNS Number : 3013U  Oxford Nanopore Technologies plc  02 December 2021

 

 

Oxford Nanopore announces technology updates at Nanopore Community Meeting

Highlights include release of new "Kit 12" and R10.4 flow cells
for >Q20 (>99%) raw read and around Q30
(99.9%) Duplex sequencing accuracy, and the new PromethION P2 device, a
palm-sized, high-throughput sequencer that delivers the most accessible
low-cost, high-output Oxford Nanopore sequencer

Oxford, UK:  Oxford Nanopore has provided a technology update at its Nanopore
Community Meeting, describing a range of product releases and upgrades. These
include the release of "Kit 12", a new kit that includes the latest "Q20+"
chemistry and enables "Duplex" sequencing. This is coupled with the release
of R10.4 flow cells. Users of nanopore sequencing can now
achieve >Q20 raw read/"simplex" accuracy or around Q30 Duplex
accuracy, and enhanced, high-accuracy consensus sequencing and variant
calling, using these released products.

The Company has also announced PromethION 2 (P2), a device that can run up
to two high-throughput PromethION Flow Cells, which will be available in
starter packs from US$10,455. The P2 is designed to bring low-cost nanopore
sequencing for large genomes or high-throughput long-read transcriptomics,
without the requirement for capital investment
and with minimal infrastructure requirement. P2 will be available as a
standalone device with integrated compute, or "P2 Solo", a sequencing device
that can be connected to existing compute, including GridION. P2 Solo will be
shipped from Q2 2022 and Oxford Nanopore is now taking pre orders here
(https://nanoporetech.com/products/p2) .    

Oxford Nanopore also introduced Remora, a new tool for methylation
analysis. Remora further enhances base-modification analysis, and is used
during the experiment (concurrent to standard basecalling), at no additional
cost, while maintaining high-accuracy basecalling of native bases. Remora
provides industry-leading performance at only 20X coverage.

"Short fragment mode" (SFM), to optimise accurate, high-throughput
sequencing of shorter fragments as short as 20 bp, will be fully enabled in
the new year.  Oxford Nanopore's technology sequences DNA or RNA molecules
of any length, from short to ultra-long. However, software output settings
have historically avoided shorter "adapter only" reads. SFM is designed to
optimise applications where larger volumes of shorter fragments require
high-accuracy analysis, supporting as many as 250M native human reads, at ~200
bp, on a PromethION flow cell.

"Path to in-field liquid biopsy". R&D pipeline programmes were reviewed,
including chemistries such as "inny" and "outy", that capture a single
molecule of DNA and make multiple measurements of that single molecule. These
techniques have the potential to deliver "Adaptive Accuracy" - supporting
capture and re-reading of rare variants in a mixed sample.  could be paired
with liquid biopsy workflows in the lab or in the field, potentially enabling
easy-to-use remote "liquid biopsy" sequencing.

The Company is developing an integrated sequencer and tablet;
the MinION Mk1D (https://nanoporetech.com/products/minion-mk1d) , that would
be capable of processing the high data volumes produced by MinION and could
be used for this purpose.

Nanopore Community Meeting

The annual Nanopore Community Meeting, held online in 2021, has this year
featured more than 50 user talks, spanning areas including human genetics,
clinical / cancer research, microbiology including genomic epidemiology, plant
and animal research and bioinformatics.  Write ups and videos of the talks
are made available on the nanopore website.  At the meeting, Oxford Nanopore
provided a technology update, featuring Clive G Brown (CTO) and talks from
James Clarke, Stuart Reid and Rosemary Sinclair Dokos. 

For a complete overview of these and more announcements, please visit Oxford
Nanopore's website at
https://nanoporetech.com/about-us/news/oxford-nanopore-announces-technology-updates-nanopore-community-meeting
(https://nanoporetech.com/about-us/news/oxford-nanopore-announces-technology-updates-nanopore-community-meeting)
 

 

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